17 recruiting, 11 unknown, 10 completed, 8 not yet recruiting. 24 Phase 2, 9 Not applicable, 5 Phase 1, 5 Phase 3.
Follow Locally Advanced Cervical Cancer: new trials by email Literature Review of Locally Advanced Cervical Cancer trials Research Report on Locally Advanced Cervical Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Perioperative Adebrelimab for Locally Advanced Cervical Cancer Adebrelimab, Paclitaxel, Cisplatin - Locally Advanced Cervical Cancer | Phase 2 | Not yet recruiting | Anhui Provincial Hospital | 35 | 2026-10-01 | 2026-09-10 |
| Clinical Feasibility of the ARCHITECT Applicator in Cervical Cancer Brachytherapy ARCHITECT applicator - Locally Advanced Cervical Cancer, Uterine Carcinoma | Not applicable | Recruiting | Erasmus Medical Center | 25 | 2026-07-22 | 2026-09-25 |
| Evaluation of Persistent Infection by Oncogenic Human Papillomavirus (HPV) in Patients Treated for Cervical Carcinoma and Its Relation to Prognostic Factors Locally Advanced Cervical Cancer, Prognostic Biomarker | Not yet recruiting | Instituto do Cancer do Estado de São Paulo | 100 | 2026-05-10 | 2026-06-03 | |
| A Clinical Study of Nanocrystalline Megestrol Acetate in Concurrent Chemoradiotherapy for Locally Advanced Cervical Cancer Nanocrystalline Megestrol Acetate Oral Suspension - Locally Advanced Cervical Cancer, Cachexia | Phase 1 | Recruiting | Second Xiangya Hospital of Central South University | 88 | 2026-04-30 | 2026-04-24 |
| Cadonilimab Combined With RT in LACC Patients Ineligible for CCRT Cadonilimab, RT - Locally Advanced Cervical Cancer | Phase 2 | Not yet recruiting | Ruijin Hospital | 45 | 2026-03-01 | 2026-03-05 |
| Vitamin D Status and Clinical Outcomes in Locally Advanced Cervical Cancer Pretreatment Vitamin D Assessment in Serum and Cervical Lavage Fluid - Locally Advanced Cervical Cancer, Vitamin D Concentration | Recruiting | University of Kragujevac | 100 | 2026-01-01 | 2026-08-04 | |
| This is a Multicentre International Study Evaluating CT-based IGABT With / Without Either TRUS During BT/Pre BT MR as Per IBS-GECESTRO-ABS Recommendations for Target contouring-as an Alternative to MRIGABT for Cervical Cancer From Implementation Perspectives Under EMBRACE-III:TRIPLET IMPACT Study. CT IGABT - Locally Advanced Cervical Cancer, Brachytherapy | Not yet recruiting | Homi Bhabha Cancer Hospital & Research Centre | 1200 | 2025-11-01 | 2025-11-25 | |
| Iparomlimab/Tuvonralimab Combined With Nab-paclitaxel and Cisplatin as Neoadjuvant Therapy for Locally Advanced Cervical Cancer Iparomlimab/Tuvonralimab, nab-paclitaxel, Cisplatin - Locally Advanced Cervical Cancer | Phase 2 | Recruiting | Xijing Hospital | 34 | 2025-09-25 | 2026-10-15 |
| Neoadjuvant Iparomlimab and Tuvonralimab Plus Chemotherapy-eclipse for Locally Advanced Cervical Cancer (NICE-CC) neoadjuvant chemo-immunotherapy: Iparomlimab and tuvonralimab plus cisplatin,nab-paclitaxel for 1 cycle and Iparomlimab and tuvonralimab for 2 cycles - Locally Advanced Cervical Cancer | Phase 2 | Recruiting | Fujian Cancer Hospital | 43 | 2025-08-21 | 2025-09-11 |
| Neoadjuvant Chemo-immunotherapy Followed by Concurrent Chemoradiotherapy and Immunotherapy in LACC Neoadjuvant Chemotherapy (NACT) - Locally Advanced Cervical Cancer | Phase 2 | Not yet recruiting | RenJi Hospital | 30 | 2025-04-05 | 2025-04-08 |
| A Study of Volrustomig in Women With High Risk Locally Advanced Cervical Cancer (IVOLGA) Volrustomig - Locally Advanced Cervical Cancer | Phase 2 | Active not recruiting | AstraZeneca | 37 | 2025-03-31 | 2026-08-18 |
| QL1706 Plus Neoadjuvant Chemotherapy Followed by Type I Hysterectomy for Locally Advanced Cervical Cancer QL1706+TC - Neoadjuvant Immunotherapy, Locally Advanced Cervical Cancer | Phase 2 | Active not recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 54 | 2025-03-28 | 2026-05-15 |
| US Radiomics in Advanced Cervical Cancer Radiomic Analysis of Ultrasound Images - Uterine Cervical Neoplasms, Locally Advanced Cervical Cancer | Completed | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 220 | 2025-03-25 | 2025-05-22 | |
| A Clinical Study of Pelvic Concurrent Chemoradiotherapy Combined with CT-guided Intracavitary Brachytherapy with Adaptive Simultaneous Dose Escalation for Locally Advanced Cervical Cancer Brachytherapy and CT-guided online adaptive external beam pelvic radiotherapy are delivered on the same day - Locally Advanced Cervical Cancer | Not applicable | Not yet recruiting | Peking University Third Hospital | 20 | 2025-03-15 | 2025-03-18 |
| Neoadjuvant Chemotherapy Plus Cadonilimab for Locally Advanced Cervical Cancer Cadonilimab combined with cisplatin - Female, Age ≥ 18 Years Old, No Previous Systemic Treatment for the Current Disease, Including Surgery, Antitumor Radiochemotherapy/Immunotherapy | Phase 2 | Recruiting | The First Affiliated Hospital of Zhengzhou University | 29 | 2025-03-10 | 2025-08-05 |
| Study of Laparoscopic Radical Hysterectomy Based on Space Anatomy in Patients With IB3 and IIA2 Cervical Cancer Laparoscopic radical hysterectomy based on space anatomy, Abdominal radical hysterectomy - Locally Advanced Cervical Cancer | Not yet recruiting | International Peace Maternity and Child Health Hospital | 500 | 2024-12-27 | 2025-01-06 | |
| Study on Disease Characteristics and Treatment in Locally Advanced or Recurrent / Metastatic Cervical Cancer in Italy Cervical Cancer, Locally Advanced Cervical Cancer | Recruiting | MSD Italia S.r.l. | 200 | 2024-12-17 | 2025-07-20 | |
| CNCMT：a Multi-center, Prospective, Single-arm Study Neoadjuvant Chemotherapy (NACT), maintenance therapy - Locally Advanced Cervical Cancer, PD1 | Not applicable | Enrolling by invitation | Hubei Cancer Hospital | 20 | 2024-10-08 | 2026-09-18 |
| Neoadjuvant Immunochemotherapy in PD-L1-negative LACC Camrelizumab, Paclitaxel-albumin, Cisplatin - Cervical Cancer, Locally Advanced Cervical Cancer | Phase 2 | Recruiting | Tongji Hospital | 40 | 2024-09-12 | 2025-03-20 |
| Neoadjuvant Chemoimmunotherapy Versus Concurrent Chemoradiotherapy for LACC Camrelizumab, Cisplatin, Nab paclitaxel - Cervical Cancer, Locally Advanced Cervical Cancer | Phase 2 / Phase 3 | Recruiting | Tongji Hospital | 440 | 2024-04-22 | 2024-10-30 |
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Uterine Cervical Neoplasms (15) · Cachexia (1) · Neoplasm, Residual (1) · Pancreatic Neoplasms (1) · Pathologic Complete Response (1) · Radiation Injuries (1) · Vitamin D Deficiency (1)
Neoplasms (16) · Female Urogenital Diseases (15) · Female Urogenital Diseases and Pregnancy Complications (15) · Genital Diseases (15) · Genital Diseases, Female (15) · Genital Neoplasms, Female (15) · Neoplasms by Site (15) · Urogenital Diseases (15) · Urogenital Neoplasms (15) · Uterine Cervical Diseases (15) · Uterine Diseases (15) · Uterine Neoplasms (15) · Pathological Conditions, Signs and Symptoms (2) · Avitaminosis (1) · Body Weight (1)
Cisplatin (15) · Brachytherapy (5) · Carboplatin (5) · Paclitaxel (4) · Radiotherapy (4) · camrelizumab (4) · Chemoradiotherapy (3) · Neoadjuvant Therapy (2) · 130-nm albumin-bound paclitaxel (1) · Albumin-Bound Paclitaxel (1) · Blood Specimen Collection (1) · Curcumin (1) · Drug Therapy (1) · Everolimus (1) · Gemcitabine (1)
Chongqing University Cancer Hospital (6) · AstraZeneca (3) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (2) · Lei Li (2) · National Institute of Cancerología (2) · Tongji Hospital (2) · Washington University School of Medicine (2) · AHS Cancer Control Alberta (1) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Anhui Provincial Hospital (1) · Barts & The London NHS Trust (1) · Erasmus Medical Center (1) · Far Eastern Memorial Hospital (1) · Fudan University (1) · Fujian Cancer Hospital (1)
China (29) · Italy (4) · Mexico (4) · United States (4) · Brazil (3) · India (3) · Taiwan (3) · France (2) · Japan (2) · Netherlands (2) · Peru (2) · Poland (2) · Russia (2) · South Korea (2) · Canada (1)
Dongling Zou, M.D. (3) · Ding Ma (2) · Lei Li, M.D. (2) · Bradley Monk, M.D (1) · Camilla Culcasi (1) · Denisse Castro, RDN, PhD (1) · Dr Umesh Mahantshetty, MD, DNB (1) · Eder A Arango, MD (1) · Emanuela Romano, MD (1) · Heming Lu, MS (1) · Hongxi Zhao, PhD (1) · Imran Zoberi, M.D. (1) · Johann Tang (1) · Kevin Albuquerque, M.D. (1)
PMID 15763303, PMID 25827291, PMID 25847525, PMID 26568261, PMID 26904570, PMID 27107038, PMID 28840453, PMID 29095678, PMID 29594251, PMID 29850653, PMID 30146092, PMID 30659131, PMID 30774597, PMID 30943124, PMID 31188324, PMID 31348579, PMID 31487218, PMID 31812369, PMID 31924334, PMID 32447296, PMID 33119110, PMID 33794207, PMID 34019918, PMID 34534429, PMID 37145263, PMID 37306763, PMID 37349318, PMID 38039991, PMID 41775252
2017 (1), 2018 (1), 2023 (1), U54CA274318 (1)