4 completed, 2 recruiting, 2 unknown. 8 Phase 2, 6 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Completed 4, Recruiting 2, Unknown 2 |
| Phase 1 | 6 | Completed 3, Unknown 2, Recruiting 1 |
Follow Limbal Stem Cell Deficiency: new trials by email Literature Review of Limbal Stem Cell Deficiency trials Research Report on Limbal Stem Cell Deficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Topical Mesenchymal Stromal Cell Secretome for Ocular Surface Disease Allogeneic Bone-Marrow Derived Mesenchymal Stromal Cells Secretome, Vehicle Control - Persistent Corneal Epithelial Defect, Corneal Epithelial Disorders | Phase 2 | Recruiting | University of Illinois Chicago | 24 | 2025-08-01 | 2026-10-28 |
| Cultured Autologous Oral Mucosa Epithelial Sheet for the Treatment of Bilateral Limbal Stem Cell Deficiency FEMJA transplatation - Total Bilateral Limbal Cell Deficiency | Phase 1 / Phase 2 | Recruiting | Hospices Civils de Lyon | 40 | 2020-11-13 | 2025-12-16 |
| Allogeneic ABCB5-positive Limbal Stem Cells for Treatment of LSCD LSC2 - Limbal Stem Cell Deficiency | Phase 1 / Phase 2 | Unknown | RHEACELL GmbH & Co. KG | 16 | 2019-07-04 | 2022-10-07 |
| Transplantation of Autologous Oral Mucosal Epithelial Stem Cell Sheet for Treating Limbal Stem Cell Deficiency Disease cultured autologous oral mucosal epithelial cell sheet - Limbal Stem Cell Deficiency | Phase 1 / Phase 2 | Unknown | He Eye Hospital | 7 | 2017-01-01 | 2017-01-10 |
| Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) Graft Biopsy to collect limbal epithelial stem cells that will be cultivated into a graft, Cultivation of Limbal epithelial cells into a graft, CALEC Transplant - Limbal Stem Cell Deficiency | Phase 1 / Phase 2 | Completed | Massachusetts Eye and Ear Infirmary | 23 | 2016-08-01 | 2025-01-15 |
| Limbal Epithelial Stem Cell Transplantation: a Phase II Multicenter Trial Limbal epithelial stem cell graft - Limbal Stem Cell Deficiency | Phase 2 | Completed | University Hospital, Antwerp | 27 | 2015-04-01 | 2025-01-15 |
| Transplantation of Autologous Oral Mucosal Epithelial Sheets for Limbal Stem-cell Deficiency Mucosal cell sheet transplantation - Limbal Stem-cell Deficiency | Phase 1 / Phase 2 | Completed | Siriraj Hospital | 6 | 2013-04-17 | 2019-10-11 |
| Autologous Transplantation of Cultivated Limbal Stem Cells on Amniotic Membrane in Limbal Stem Cell Deficiency (LSD) Patients Cultured limbal stem cells Transplantation - Limbal Stem Cell Deficiency | Phase 1 / Phase 2 | Completed | Royan Institute | 10 | 2007-10-01 | 2011-07-15 |
Corneal Injuries (1) · Corneal Neovascularization (1) · Corneal Opacity (1) · Eye Injuries (1)
Corneal Diseases (8) · Eye Diseases (8) · Craniocerebral Trauma (1) · Facial Injuries (1) · Metaplasia (1) · Neovascularization, Pathologic (1) · Nervous System Diseases (1) · Pathologic Processes (1) · Pathological Conditions, Signs and Symptoms (1) · Trauma, Nervous System (1) · Wounds and Injuries (1)
Transplantation (1)
He Eye Hospital (1) · Hospices Civils de Lyon (1) · Massachusetts Eye and Ear Infirmary (1) · RHEACELL GmbH & Co. KG (1) · Royan Institute (1) · Siriraj Hospital (1) · University Hospital, Antwerp (1) · University of Illinois Chicago (1)
United States (3) · Belgium (1) · France (1) · Germany (1) · Iran (1) · Thailand (1)
Adisak Wongkajornsilp, M.D., Ph.D. (1) · Ali R Djalilian, MD (1) · Alireza Baradaran, MD (1) · Gerd U. Auffarth, Prof.Dr.med. (1) · Hamid Gorabi, PhD (1) · Hossein Baharvand, PhD (1) · Marzieh Ebrahimi, PhD (1) · Mohammadali Javadi, MD (1) · Sorcha Ni Dhubhghaill (1) · Ula Jurkunas, MD (1)
PMID 24589151, PMID 35922868, PMID 40038272, PMID 40152603, PMID 41503585
3UH3EY031809-04S1 (1)