5 completed, 3 unknown, 2 recruiting, 1 active not recruiting. 11 Phase 1, 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 11 | Completed 5, Unknown 3, Recruiting 2, Active not recruiting 1 |
| Phase 2 | 6 | Completed 3, Unknown 2, Recruiting 1 |
Follow Limbal Stem Cell Deficiency: new trials by email Literature Review of Limbal Stem Cell Deficiency trials Research Report on Limbal Stem Cell Deficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Subjects With Limbal Stem Cell Deficiency CSB-001 Ophthalmic Solution 0.1% - Limbal Stem Cell Deficiency | Phase 1 | Recruiting | Claris Biotherapeutics, Inc. | 75 | 2024-05-15 | 2026-08-13 |
| Treatment of LSCD With DM transplantation of a Descemet's Membrane corneal onlay, partial LSCD, transplantation of a Descemet's Membrane corneal onlay, total/near-total LSCD - Limbal Stem-cell Deficiency, Congenital Aniridia | Phase 1 | Completed | University of Minnesota | 19 | 2023-11-30 | 2026-01-08 |
| Cultured Autologous Oral Mucosa Epithelial Sheet for the Treatment of Bilateral Limbal Stem Cell Deficiency FEMJA transplatation - Total Bilateral Limbal Cell Deficiency | Phase 1 / Phase 2 | Recruiting | Hospices Civils de Lyon | 40 | 2020-11-13 | 2025-12-16 |
| Stem Cell Therapy for Limbal Stem Cell Deficiency cLSC, Scleral contact lens (SCL) - Limbal Stem-cell Deficiency | Phase 1 | Active not recruiting | University of California, Los Angeles | 20 | 2020-09-30 | 2026-02-10 |
| Allogeneic ABCB5-positive Limbal Stem Cells for Treatment of LSCD LSC2 - Limbal Stem Cell Deficiency | Phase 1 / Phase 2 | Unknown | RHEACELL GmbH & Co. KG | 16 | 2019-07-04 | 2022-10-07 |
| Transplantation of Autologous Oral Mucosal Epithelial Stem Cell Sheet for Treating Limbal Stem Cell Deficiency Disease cultured autologous oral mucosal epithelial cell sheet - Limbal Stem Cell Deficiency | Phase 1 / Phase 2 | Unknown | He Eye Hospital | 7 | 2017-01-01 | 2017-01-10 |
| Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) Graft Biopsy to collect limbal epithelial stem cells that will be cultivated into a graft, Cultivation of Limbal epithelial cells into a graft, CALEC Transplant - Limbal Stem Cell Deficiency | Phase 1 / Phase 2 | Completed | Massachusetts Eye and Ear Infirmary | 23 | 2016-08-01 | 2025-01-15 |
| Cultivated Autologous Oral Mucosal Epithelial Transplantation Cultivated oral mucosal epithelial cell transplantation - Limbal Stem Cell Deficiency | Phase 1 | Unknown | Chang Gung Memorial Hospital | 8 | 2016-03-01 | 2020-08-13 |
| Transplantation of Autologous Oral Mucosal Epithelial Sheets for Limbal Stem-cell Deficiency Mucosal cell sheet transplantation - Limbal Stem-cell Deficiency | Phase 1 / Phase 2 | Completed | Siriraj Hospital | 6 | 2013-04-17 | 2019-10-11 |
| The Improvement of Limbal Stem Cell Deficiency (LSCD) in Unilateral Stem Cell Damage by Amniotic Membrane Extract Eye Drop (AMEED) Amniotic Membrane Extract Eye Drop (AMEED) - Limbal Stem Cell Deficiency (LSCD) | Phase 1 | Completed | Royan Institute | 10 | 2011-08-01 | 2016-01-07 |
| Autologous Transplantation of Cultivated Limbal Stem Cells on Amniotic Membrane in Limbal Stem Cell Deficiency (LSD) Patients Cultured limbal stem cells Transplantation - Limbal Stem Cell Deficiency | Phase 1 / Phase 2 | Completed | Royan Institute | 10 | 2007-10-01 | 2011-07-15 |
Aniridia (1) · Corneal Diseases (1) · Corneal Injuries (1) · Corneal Neovascularization (1) · Corneal Opacity (1) · Eye Injuries (1)
Eye Diseases (11) · Corneal Diseases (10) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Craniocerebral Trauma (1) · Eye Abnormalities (1) · Eye Diseases, Hereditary (1) · Facial Injuries (1) · Genetic Diseases, Inborn (1) · Iris Diseases (1) · Metaplasia (1) · Neovascularization, Pathologic (1) · Nervous System Diseases (1) · Pathologic Processes (1) · Pathological Conditions, Signs and Symptoms (1)
Transplantation (1)
Royan Institute (2) · Chang Gung Memorial Hospital (1) · Claris Biotherapeutics, Inc. (1) · He Eye Hospital (1) · Hospices Civils de Lyon (1) · Massachusetts Eye and Ear Infirmary (1) · RHEACELL GmbH & Co. KG (1) · Siriraj Hospital (1) · University of California, Los Angeles (1) · University of Minnesota (1)
United States (5) · France (1) · Germany (1) · Iran (1) · Taiwan (1) · Thailand (1)
Alireza Baradaran, MD (2) · Marzieh Ebrahimi, PhD (2) · Adisak Wongkajornsilp, M.D., Ph.D. (1) · David Hui-Kang Ma, MD, PhD (1) · Gerd U. Auffarth, Prof.Dr.med. (1) · Hamid Gorabi, PhD (1) · Hamid Gourabi, PhD (1) · Hossein Baharvand, PhD (1) · Maryam Momeni, MSc (1) · Mitra Akbari, MD (1) · Mohammadali Javadi, MD (1) · Niloufar Shayan, MSc (1) · Sophie Deng, MD, PhD (1) · Stephen Kaufman, MD (1) · Ula Jurkunas, MD (1)
PMID 15377551, PMID 16458679, PMID 16989763, PMID 17251457, PMID 19373264, PMID 19458337, PMID 21097786, PMID 21571372, PMID 21652025, PMID 22850415, PMID 23087419, PMID 27824126, PMID 34620226, PMID 35922868, PMID 40038272, PMID 40152603, PMID 41503585
R01EY021797 (1)