4 completed, 4 recruiting. 5 Phase 4, 3 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 5 | Recruiting 3, Completed 2 |
| Not applicable | 3 | Completed 2, Recruiting 1 |
Follow Injection Drug Use: new trials by email Literature Review of Injection Drug Use trials Research Report on Injection Drug Use
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Long-acting Cabotegravir Injectable Pre-exposure Prophylaxis for People Who Inject Drugs APRETUDE (cabotegravir) - HIV, Substance Use Disorder (SUD) | Phase 4 | Recruiting | Massachusetts General Hospital | 100 | 2026-02-24 | 2026-03-19 |
| Feasibility of Internet-based HIV Prevention Research Mail delivery of at-home self-administered HIV tests - HIV Prevention, Injection Drug Use | Not applicable | Recruiting | Montefiore Medical Center | 500 | 2025-08-01 | 2026-06-04 |
| Implementing Low-Barrier HCV Treatment in a Jail Setting Sofosbuvir / Velpatasvir Oral Tablet [Epclusa], Community Health Worker - HEPATITIS C (HCV), Incarceration | Phase 4 | Recruiting | Lifespan | 40 | 2025-06-11 | 2026-02-27 |
| Assessment of Metformin for Restoration of Immune Homeostasis in HIV+ and HIV- Individuals With a History of Injection Drug Use Metformin, Placebo, Jynneos - Systemic Inflammation, Immune Dysregulation | Phase 4 | Recruiting | University of Alabama at Birmingham | 100 | 2025-04-07 | 2026-04-22 |
| Ending Transmission of HIV, HCV, and STDs and Overdose in Rural Communities of People Who Inject Drugs (ETHIC) Referral to harm reduction services - HIV, Hepatitis C | Not applicable | Completed | University of Chicago | 306 | 2020-08-14 | 2024-12-12 |
| The Kentucky Viral Hepatitis Treatment Study Sofosbuvir/velpatasvir (Epclusa®) - Hepatitis C, Opioid-Related Disorders | Phase 4 | Completed | Jennifer Havens | 380 | 2019-09-23 | 2026-10-20 |
| A Pilot Study to Evaluate Skin Swabbing With Chlorhexidine to Prevent Skin And Soft Tissue Infections Among People Who Inject Drugs Chlorhexidine gluconate, Isopropyl Alcohol 70% Topical Application Solution, Skin Prep Before Injecting Recreational/Street Drugs - Opioid Use Disorder, Injection Drug Use | Phase 4 | Completed | Gabriel John Culbert | 56 | 2018-10-01 | 2025-08-03 |
| Pilot Test of a Community-based Buprenorphine Treatment Intervention Community-based buprenorphine treatment (CBBT) intervention - Opioid Dependence, Injection Drug Use | Not applicable | Completed | Albert Einstein College of Medicine | 77 | 2012-12-01 | 2018-04-23 |
Opioid-Related Disorders (4) · Hepatitis C (3) · Soft Tissue Infections (1) · Substance-Related Disorders (1)
Chemically-Induced Disorders (5) · Mental Disorders (5) · Infections (4) · Narcotic-Related Disorders (4) · Substance-Related Disorders (4) · Blood-Borne Infections (3) · Communicable Diseases (3) · Digestive System Diseases (3) · Flaviviridae Infections (3) · Hepatitis (3) · Hepatitis, Viral, Human (3) · Liver Diseases (3) · RNA Virus Infections (3) · Virus Diseases (3)
Sofosbuvir (2) · sofosbuvir-velpatasvir drug combination (2) · velpatasvir (2) · 2-Propanol (1) · Community Health Workers (1) · Illicit Drugs (1) · Metformin (1) · Methods (1) · cabotegravir (1) · chlorhexidine gluconate (1) · smallpox and monkeypox vaccine modified vaccinia ankara-bavarian nordic (1)
Albert Einstein College of Medicine (1) · Gabriel John Culbert (1) · Jennifer Havens (1) · Lifespan (1) · Massachusetts General Hospital (1) · Montefiore Medical Center (1) · University of Alabama at Birmingham (1) · University of Chicago (1)
United States (8)
Aaron Fox (1) · Chinazo Cunningham, MD, MS (1) · Jennifer Havens, PhD (1) · Mai Pho, PhD (1)
PMID 34226208, PMID 35468860, PMID 36403075, PMID 41027703
4UH3DA044829-03 (1), K24DA057873 (1), R01DA047952 (1), R01DA060692 (1), R34DA031066 (1), R34DA061732 (1)