3 completed, 1 withdrawn. 2 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 2 | Completed 1, Withdrawn 1 |
| Phase 3 | 2 | Completed 2 |
Follow High-grade Squamous Intraepithelial Lesion: new trials by email Literature Review of High-grade Squamous Intraepithelial Lesion trials Research Report on High-grade Squamous Intraepithelial Lesion
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Imiquimod, Fluorouracil, or Observation in Treating HIV-Positive Patients With High-Grade Anal Squamous Skin Lesions imiquimod, fluorouracil, questionnaire administration - Anal Intraepithelial Neoplasia, High-grade Squamous Intraepithelial Lesion | Phase 3 | Completed | AIDS Malignancy Consortium | 91 | 2015-12-28 | 2025-07-23 |
| Treatment in Preventing Anal Cancer in Patients With HIV and Anal High-Grade Lesions imiquimod, fluorouracil, infrared photocoagulation therapy - Anal Cancer, High-grade Squamous Intraepithelial Lesion | Phase 3 | Completed | AIDS Malignancy Consortium | 4446 | 2014-09-24 | 2024-07-26 |
| SGN-00101 Vaccine in Treating Human Papillomavirus in Patients Who Have Abnormal Cervical Cells HspE7, placebo, laboratory biomarker analysis - Atypical Squamous Cells of Undetermined Significance, Cervical Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 139 | 2004-09-01 | 2013-06-03 |
| S0212 Celecoxib in Treating Patients With High-Grade Squamous Intraepithelial Lesions of the Cervix celecoxib, anti-cytokine therapy, antiangiogenesis therapy - Stage 0 Cervical Cancer, High-grade Squamous Intraepithelial Lesion | Phase 2 | Withdrawn | SWOG Cancer Research Network | 2013-11-08 |
Squamous Intraepithelial Lesions (4) · HIV Infections (2) · Acquired Immunodeficiency Syndrome (1) · Anus Neoplasms (1) · Atypical Squamous Cells of the Cervix (1) · Papillomavirus Infections (1) · Uterine Cervical Dysplasia (1) · Uterine Cervical Neoplasms (1)
Genital Diseases (4) · Morphological and Microscopic Findings (4) · Pathological Conditions, Signs and Symptoms (4) · Urogenital Diseases (4) · Neoplasms (3) · Blood-Borne Infections (2) · Communicable Diseases (2) · Female Urogenital Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Genital Diseases, Female (2) · Immune System Diseases (2) · Immunologic Deficiency Syndromes (2) · Infections (2) · Lentivirus Infections (2) · Neoplasms by Site (2)
Fluorouracil (2) · Imiquimod (2) · Biological Therapy (1) · Celecoxib (1) · Chemoprevention (1) · Laser Therapy (1) · Light Coagulation (1) · Observation (1) · Watchful Waiting (1)
AIDS Malignancy Consortium (2) · National Cancer Institute (NCI) (1) · SWOG Cancer Research Network (1)
United States (3) · Puerto Rico (2)
Frank Meyskens (1) · Joel Palefsky, MD (1) · Timothy Wilkin (1) · William R. Robinson, MD (1)
PMID 33594934, PMID 35416975, PMID 35704479, PMID 40801169
U01CA121947 (2), U10CA037429 (1), UM1CA121947 (1)