5 completed, 2 unknown, 1 terminated. 8 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 8 | Completed 5, Unknown 2, Terminated 1 |
| Phase 2 | 3 | Completed 1, Terminated 1, Unknown 1 |
Follow Heroin Dependence: new trials by email Literature Review of Heroin Dependence trials Research Report on Heroin Dependence
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Buprenorphine/Naloxone Dose on Experimental Stress Reactivity and Opioid Abstinence Extended release morphine, Buprenorphine/Naloxone low dose, Buprenorphine/Naloxone moderate dose - Heroin Dependence, Opioid Use Disorder | Phase 1 / Phase 2 | Completed | Wayne State University | 26 | 2016-12-01 | 2020-11-10 |
| Diversion to Treatment for Injection Drug Users Arrested for Possession of Heroin Methadone, Buprenorphine, Employment-based drug abstinence reinforcement - Cocaine-Related Disorders, HIV | Phase 1 | Completed | Johns Hopkins University | 1 | 2012-12-01 | 2014-12-11 |
| Pioglitazone for Heroin and for Nicotine Dependence PIO, Placebo - Heroin Dependence, Nicotine Dependence | Phase 1 / Phase 2 | Terminated | New York State Psychiatric Institute | 82 | 2011-03-01 | 2017-07-13 |
| Community Reinforcement and Family Training for Drug Abuse Treatment Retention/HIV Risk Reduction CRAFT-T, Treatment as usual - Heroin Dependence, Opiate Dependence | Phase 1 / Phase 2 | Unknown | University of Cincinnati | 104 | 2008-03-01 | 2012-08-14 |
| Ability of Aprepitant to Block Opioid Reward in Non-Dependent Opiate Abusers aprepitant, Pseudo-placebo - buprenorphine - Opioid-Related Disorders, Heroin Dependence | Phase 1 | Unknown | Karolinska University Hospital | 60 | 2008-01-01 | 2008-08-01 |
| Effect of Clonidine on Responses to Imagery Scripts Clonidine, Placebo - Cocaine Abuse, Heroin Abuse | Phase 1 | Completed | National Institute on Drug Abuse (NIDA) | 92 | 2005-06-14 | 2018-04-05 |
| Effectiveness of Naltrexone and Lofexidine in Treating Detoxified Heroin Addicts - 1 Lofexidine - Heroin Dependence | Phase 1 | Completed | National Institute on Drug Abuse (NIDA) | 2003-03-01 | 2017-01-12 | |
| Buprenorphine and Naloxone Combination Study - 10 Buprenorphine/naloxone - Heroin Dependence, Opioid-Related Disorders | Phase 1 | Completed | National Institute on Drug Abuse (NIDA) | 1996-11-01 | 2017-01-12 |
Opioid-Related Disorders (4) · Cocaine-Related Disorders (2) · Substance-Related Disorders (2) · Behavior, Addictive (1) · Recurrence (1) · Tobacco Use Disorder (1)
Chemically-Induced Disorders (8) · Mental Disorders (8) · Narcotic-Related Disorders (8) · Substance-Related Disorders (6) · Opioid-Related Disorders (4) · Behavior (1) · Compulsive Behavior (1) · Disease Attributes (1) · Impulsive Behavior (1) · Pathologic Processes (1) · Pathological Conditions, Signs and Symptoms (1)
Buprenorphine (3) · Aprepitant (1) · Buprenorphine, Naloxone Drug Combination (1) · Clonidine (1) · Methadone (1) · Naloxone (1) · Pioglitazone (1) · Therapeutics (1) · lofexidine (1)
National Institute on Drug Abuse (NIDA) (3) · Johns Hopkins University (1) · Karolinska University Hospital (1) · New York State Psychiatric Institute (1) · University of Cincinnati (1) · Wayne State University (1)
United States (7) · Sweden (1)
Anthony DeFulio, Ph.D. (1) · Gregory S. Brigham, Ph.D. (1) · Johan Kakko, MD (1) · John Rotrosen, M.D. (1) · Kenzie Preston, Ph.D. (1) · Mark Greenwald, PhD (1) · Markus Heilig, MD, PhD (1) · Sandra D. Comer, MD (1) · Thomas R Kosten, M.D. (1)
K23DA021512 (1), R01DA031022 (1)