4 completed, 2 unknown. 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 4, Unknown 2 |
Follow Hemoglobinuria: new trials by email Literature Review of Hemoglobinuria trials Research Report on Hemoglobinuria
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase IIa Study to Assess the Safety, Efficacy, and Pharmacokinetics of Subcutaneously Administered Pegcetacoplan (APL-2) in Subjects With PNH Pegcetacoplan - PNH | Phase 2 | Completed | Apellis Pharmaceuticals, Inc. | 4 | 2018-08-16 | 2020-12-22 |
| A Long-Term Treatment Study of ACH-0144471 in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) ACH-0144471 - Paroxysmal Nocturnal Hemoglobinuria | Phase 2 | Completed | Alexion Pharmaceuticals, Inc. | 8 | 2017-06-22 | 2023-03-14 |
| Study of Danicopan in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Danicopan - Paroxysmal Nocturnal Hemoglobinuria (PNH) | Phase 2 | Completed | Alexion Pharmaceuticals, Inc. | 10 | 2017-03-31 | 2022-06-23 |
| Safety and Efficacy of Levamisole Combined With Cyclosporine A in Patients With Subclinical Paroxysmal Nocturnal Hemoglobinuria and PNH in the Setting of Another Bone Marrow Failure Syndromes(PNH-2013) Levamisole+cyclosporin A+Glucocorticoids, cyclosporin A+Glucocorticoids, Glucocorticoids - Paroxysmal Nocturnal Hemoglobinuria, Hemoglobinuria | Phase 2 | Unknown | Institute of Hematology & Blood Diseases Hospital, China | 50 | 2013-01-01 | 2013-01-03 |
| Safety and Efficacy of Levamisole Combined With Cyclosporine A in Patients With Classic Paroxysmal Nocturnal Hemoglobinuria Levamisole+cyclosporin A+Glucocorticoids, cyclosporin A+Glucocorticoids, Glucocorticoids - Paroxysmal Nocturnal Hemoglobinuria, Hemoglobinuria | Phase 2 | Unknown | Institute of Hematology & Blood Diseases Hospital, China | 120 | 2012-07-01 | 2013-01-03 |
| Mismatched Family Member Donor Transplantation for Children and Young Adults With High Risk Hematological Malignancies CliniMACS, Stem cell transplantation, Fludarabine - Leukemia, Acute Lymphocytic (ALL), Leukemia, Myeloid, Acute(AML) | Phase 2 | Completed | St. Jude Children's Research Hospital | 73 | 2007-12-14 | 2020-04-14 |
Hemoglobinuria, Paroxysmal (6) · Anemia (3) · Hematologic Diseases (3) · Anemia, Aplastic (2) · Anemia, Hemolytic (2) · Bone Marrow Failure Disorders (2) · Proteinuria (2) · Thrombosis (2) · Urination Disorders (2) · Hemolysis (1) · Hodgkin Disease (1) · Leukemia (1) · Leukemia, Myeloid, Acute (1) · Leukemia, Myelomonocytic, Juvenile (1)
Bone Marrow Diseases (6) · Female Urogenital Diseases (6) · Female Urogenital Diseases and Pregnancy Complications (6) · Hemic and Lymphatic Diseases (6) · Male Urogenital Diseases (6) · Pathological Conditions, Signs and Symptoms (6) · Signs and Symptoms (6) · Urogenital Diseases (6) · Urologic Diseases (6) · Urological Manifestations (6) · Myelodysplastic Syndromes (5) · Anemia, Hemolytic (4) · Proteinuria (4) · Urination Disorders (4) · Anemia (3)
Cyclosporine (2) · Glucocorticoids (2) · Levamisole (2) · danicopan (2) · Alemtuzumab (1) · Antilymphocyte Serum (1) · Cyclophosphamide (1) · Filgrastim (1) · Granulocyte Colony-Stimulating Factor (1) · Melphalan (1) · Muromonab-CD3 (1) · Mycophenolic Acid (1) · Rituximab (1) · Stem Cell Transplantation (1) · Thiotepa (1)
Alexion Pharmaceuticals, Inc. (2) · Institute of Hematology & Blood Diseases Hospital, China (2) · Apellis Pharmaceuticals, Inc. (1) · St. Jude Children's Research Hospital (1)
China (2) · Italy (2) · New Zealand (2) · South Korea (2) · Bulgaria (1) · Serbia (1) · United Kingdom (1) · United States (1)
Brandon Triplett, MD (1) · Federico Grossi, MD, PhD (1)
PMID 33121236, PMID 35869170, PMID 41124654
2016 (1), 2017 (1)