14 completed. 14 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 14 | Completed 14 |
| Phase 2 | 2 | Completed 2 |
Follow Graft Versus Host Disease: new trials by email Literature Review of Graft Versus Host Disease trials Research Report on Graft Versus Host Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Low-Dose Prednisone or Methylprednisolone in Treating Patients With Newly Diagnosed Acute Graft-versus-Host Disease prednisone, methylprednisolone, questionnaire administration - Graft Versus Host Disease, Recurrent Adult Acute Lymphoblastic Leukemia | Phase 3 | Completed | Fred Hutchinson Cancer Center | 164 | 2009-06-01 | 2017-08-21 |
| Cyclosporine Eye Drops in Preventing Graft-Versus-Host Disease of the Eye in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer or Bone Marrow Failure Disorder cyclosporine ophthalmic emulsion, placebo - Chronic Myeloproliferative Disorders, Graft Versus Host Disease | Phase 3 | Completed | Vanderbilt-Ingram Cancer Center | 164 | 2008-10-01 | 2017-03-07 |
| Efficacy and Safety of Prochymal® Infusion in Combination With Corticosteroids for the Treatment of Newly Diagnosed Acute Graft Versus Host Disease (GVHD) Prochymal®, Placebo, Corticosteroid - Graft Versus Host Disease | Phase 3 | Completed | Mesoblast, Inc. | 192 | 2008-01-31 | 2022-01-19 |
| Tacrolimus and Methotrexate With or Without Sirolimus in Preventing Graft-Versus-Host Disease in Young Patients Undergoing Donor Stem Cell Transplant for Acute Lymphoblastic Leukemia in Complete Remission thiotepa, cyclophosphamide, tacrolimus - B-cell Childhood Acute Lymphoblastic Leukemia, Childhood Acute Lymphoblastic Leukemia in Remission | Phase 3 | Completed | Children's Oncology Group | 146 | 2007-03-01 | 2019-08-07 |
| Sibling Donor Peripheral Stem Cell Transplant or Sibling Donor Bone Marrow Transplant in Treating Patients With Hematologic Cancers or Other Diseases filgrastim, allogeneic bone marrow transplantation, peripheral blood stem cell transplantation - Chronic Myeloproliferative Disorders, Graft Versus Host Disease | Phase 3 | Completed | The Canadian Blood and Marrow Transplant Group | 230 | 2007-03-01 | 2014-03-05 |
| Efficacy and Safety of Adult Human Mesenchymal Stem Cells to Treat Steroid Refractory Acute Graft Versus Host Disease (GVHD) Prochymal®, Placebo, Standard of Care for GVHD - Graft Versus Host Disease | Phase 3 | Completed | Mesoblast, Inc. | 260 | 2006-08-17 | 2022-02-10 |
| Extracorporeal Photopheresis for Acute Graft Versus Host Disease Extracorporeal Photopheresis - Graft Versus Host Disease, Cancer | Phase 2 / Phase 3 | Completed | Ann & Robert H Lurie Children's Hospital of Chicago | 10 | 2003-07-01 | 2025-02-12 |
| Laboratory-Treated Donor Bone Marrow in Treating Patients Who Are Undergoing a Donor Bone Marrow Transplant for Hematologic Cancer graft versus host disease prophylaxis/therapy, allogeneic bone marrow transplantation, in vitro-treated bone marrow transplantation - Graft Versus Host Disease, Leukemia | Phase 3 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 72 | 2002-12-01 | 2014-04-17 |
| Hydroxychloroquine in Treating Patients With Newly Diagnosed Chronic Graft-Versus-Host Disease cyclosporine, hydroxychloroquine, prednisone - Graft Versus Host Disease | Phase 3 | Completed | Children's Oncology Group | 82 | 2002-04-01 | 2014-02-14 |
| Beclomethasone Plus Prednisone in Treating Patients With Graft-Versus-Host Disease beclomethasone dipropionate, methylprednisolone, prednisone - Graft Versus Host Disease | Phase 3 | Completed | Memorial Sloan Kettering Cancer Center | 2002-04-01 | 2013-05-30 | |
| Methylprednisolone With or Without Daclizumab in Treating Patients With Acute Graft-Versus-Host Disease Daclizumab, methylprednisolone, Placebo - Graft Versus Host Disease | Phase 3 | Completed | Dana-Farber Cancer Institute | 105 | 2001-01-01 | 2017-01-23 |
| Treatment of Bone Marrow to Prevent Graft-Versus-Host Disease in Patients With Acute or Chronic Leukemia Undergoing Bone Marrow Transplantation anti-thymocyte globulin, filgrastim, cyclophosphamide - Graft Versus Host Disease, Leukemia | Phase 2 / Phase 3 | Completed | Chimeric Therapies | 2000-03-01 | 2013-07-10 | |
| Graft-Versus-Host Disease in Treating Patients With Recurrent or Refractory Lymphoma or Hodgkin's Disease aldesleukin, recombinant interferon gamma, busulfan - Graft Versus Host Disease, Lymphoma | Phase 3 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 50 | 1997-10-01 | 2015-07-20 |
| Graft-Versus-Host Disease Prevention in Treating Patients Who Are Undergoing Bone Marrow Transplantation cyclosporine, methotrexate, allogeneic bone marrow transplantation - Graft Versus Host Disease, Leukemia | Phase 3 | Completed | Fred Hutchinson Cancer Center | 1986-05-01 | 2011-11-30 |
Graft vs Host Disease (14) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (8) · Leukemia (5) · Leukemia, Lymphocytic, Chronic, B-Cell (5) · Lymphoma (5) · Lymphoma, Non-Hodgkin (5) · Burkitt Lymphoma (4) · Hodgkin Disease (4) · Leukemia, Myeloid, Accelerated Phase (4) · Leukemia, Myeloid, Chronic-Phase (4) · Lymphoma, B-Cell, Marginal Zone (4) · Lymphoma, Follicular (4) · Lymphoma, Large B-Cell, Diffuse (4) · Lymphoma, Large-Cell, Immunoblastic (4) · Lymphoma, Mantle-Cell (4)
Immune System Diseases (14) · Hematologic Diseases (8) · Hemic and Lymphatic Diseases (8) · Immunoproliferative Disorders (8) · Leukemia, Lymphoid (8) · Lymphatic Diseases (8) · Lymphoproliferative Disorders (8) · Neoplasms (8) · Neoplasms by Histologic Type (8) · Chronic Disease (6) · Disease Attributes (6) · Pathologic Processes (6) · Pathological Conditions, Signs and Symptoms (6) · Leukemia, B-Cell (5) · Leukemia, Myeloid (5)
Methylprednisolone (5) · Prednisone (4) · Cyclophosphamide (3) · Cyclosporine (3) · Tacrolimus (3) · Filgrastim (2) · Methotrexate (2) · Peripheral Blood Stem Cell Transplantation (2) · Radiotherapy (2) · remestemcel-l (2) · Adrenal Cortex Hormones (1) · Antilymphocyte Serum (1) · Beclomethasone (1) · Busulfan (1) · Cyclosporins (1)
Children's Oncology Group (2) · Fred Hutchinson Cancer Center (2) · Mesoblast, Inc. (2) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2) · Ann & Robert H Lurie Children's Hospital of Chicago (1) · Chimeric Therapies (1) · Dana-Farber Cancer Institute (1) · Memorial Sloan Kettering Cancer Center (1) · The Canadian Blood and Marrow Transplant Group (1) · Vanderbilt-Ingram Cancer Center (1)
United States (14) · Australia (5) · Canada (5) · New Zealand (2) · Switzerland (2) · Italy (1) · Puerto Rico (1) · Saudi Arabia (1) · United Kingdom (1)
Christopher James, PA (2) · Andrew L. Gilman, MD (1) · Georgia B. Vogelsang, MD (1) · James N. Lowder, MD (1) · Jeffrey H. Lipton, MD, PhD (1) · Madan Jagasia, MD (1) · Marco Mielcarek (1) · Michael Pulsipher, MD (1) · Miguel-Angel Perales, MD (1) · Morris Kletzel, MD (1) · Rainer F. Storb, MD (1) · Richard J. Jones, MD (1) · Sonali Chaudhury, MD (1) · Stephanie J. Lee, MD (1) · Stephen Couban, MD (1)
PMID 17889355, PMID 17925486, PMID 21149333, PMID 21669298, PMID 21689773, PMID 22157574, PMID 24497539, PMID 25862561, PMID 27515308, PMID 28935847
P01CA015396 (2), P30CA006973 (2), P01CA018029 (1), P30CA006516 (1), P30CA016056 (1), P30CA068485 (1), U10CA098543 (1)