3 completed, 2 active not recruiting, 1 recruiting, 1 terminated. 5 Phase 1, 3 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 5 | Active not recruiting 2, Completed 1, Recruiting 1, Terminated 1 |
| Phase 2 | 3 | Completed 2, Recruiting 1 |
| Phase 3 | 1 | Unknown 1 |
Follow Grade IV Astrocytoma: new trials by email Literature Review of Grade IV Astrocytoma trials Research Report on Grade IV Astrocytoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma LMP744, Conventional Surgery or Biopsy - Recurrent Glioblastoma, Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype | Phase 1 / Phase 2 | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 40 | 2026-07-15 | 2026-10-16 |
| Peds CHAMP1ON - Hematopoietic Stem Cell And Monoclonal Antibody PD-1 Blockade for RecurreNt Pediatric High-Grade Glioma exHSC, Nivolumab, Resection or biopsy - Recurrent High-grade Glioma, Grade III Astrocytoma | Phase 1 | Active not recruiting | University of Florida | 12 | 2025-07-25 | 2026-09-23 |
| Tadalafil to Overcome Immunosuppression During Chemoradiotherapy for IDH-wildtype Grade III-IV Astrocytoma Tadalafil - Grade III Astrocytoma, Grade IV Astrocytoma | Phase 1 | Completed | Washington University School of Medicine | 18 | 2021-05-14 | 2023-06-13 |
| Surgical Nivolumab And Ipilimumab For Recurrent GBM Nivolumab-Placebo, Nivolumab, Ipilimumab-Placebo - Glioblastoma, GBM | Phase 1 | Active not recruiting | Gilbert Youssef | 63 | 2021-02-01 | 2026-10-19 |
| Convection-Enhanced Delivery (CED) of MDNA55 in Adults With Recurrent or Progressive Glioblastoma MDNA55 - Glioblastoma, Grade IV Astrocytoma | Phase 2 | Completed | Medicenna Therapeutics, Inc. | 47 | 2017-04-11 | 2022-10-24 |
| Phase-1 Study of Folinic Acid to Modulate MGMT Gene in Glioblastoma Temozolomide, folinic acid at pharmacological dose is the escalated drug, High voltage radiation therapy (linear accelerator) - Grade IV Astrocytoma, Glioblastoma | Phase 1 | Terminated | Institut Cancerologie de l'Ouest | 24 | 2013-01-01 | 2023-02-21 |
| Study To Test the Safety and Efficacy of TVI-Brain-1 As A Treatment for Recurrent Grade IV Glioma TVI-Brain-1 - Grade IV Glioma, Grade IV Astrocytoma | Phase 2 | Completed | TVAX Biomedical | 14 | 2011-06-01 | 2023-07-03 |
| Study of a Drug [DCVax®-L] to Treat Newly Diagnosed GBM Brain Cancer Dendritic cell immunotherapy - Glioblastoma Multiforme, Glioblastoma | Phase 3 | Unknown | Northwest Biotherapeutics | 348 | 2006-12-01 | 2022-05-18 |
Glioblastoma (8) · Glioma (6) · Brain Neoplasms (4) · Astrocytoma (3) · Neoplasms (3) · Central Nervous System Neoplasms (2) · Brain Diseases (1) · Central Nervous System Diseases (1) · Ependymoma (1) · Neoplasms by Histologic Type (1) · Neoplasms, Nerve Tissue (1) · Nervous System Diseases (1) · Nervous System Neoplasms (1) · Oligodendroglioma (1) · Recurrence (1)
Neoplasms, Germ Cell and Embryonal (8) · Neoplasms, Glandular and Epithelial (8) · Neoplasms, Neuroepithelial (8) · Neuroectodermal Tumors (8) · Neoplasms by Histologic Type (7) · Neoplasms, Nerve Tissue (7) · Astrocytoma (5) · Neoplasms (5) · Neoplasms by Site (4) · Brain Diseases (3) · Central Nervous System Diseases (3) · Nervous System Diseases (3) · Nervous System Neoplasms (3) · Central Nervous System Neoplasms (2) · Glioma (2)
Biopsy (2) · Nivolumab (2) · Adjuvants, Immunologic (1) · Cancer Vaccines (1) · Ipilimumab (1) · Particle Accelerators (1) · Surgical Procedures, Operative (1) · Tadalafil (1) · Temozolomide (1) · interleukin-4-Pseudomonas exotoxin (1)
Gilbert Youssef (1) · Institut Cancerologie de l'Ouest (1) · Medicenna Therapeutics, Inc. (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · Northwest Biotherapeutics (1) · TVAX Biomedical (1) · University of Florida (1) · Washington University School of Medicine (1)
United States (7) · Canada (1) · France (1) · Germany (1) · United Kingdom (1)
Gary Wood, Ph.D. (1) · Gilbert Youssef, MD (1) · Jiayi Huang, M.D. (1) · John Ligon, MD (1) · Linda Liau, M.D. (1) · Marnix L. Bosch, MBA, PhD (1) · Sadhana Jackson, M.D. (1)
PMID 23545055, PMID 29843811, PMID 33863808, PMID 36394838, PMID 36640127