5 completed, 4 active not recruiting, 4 terminated, 2 recruiting. 19 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 19 | Completed 5, Active not recruiting 4, Terminated 4, Recruiting 2, Unknown 2, Withdrawn 2 |
Follow Glioblastoma Multiforme: new trials by email Literature Review of Glioblastoma Multiforme trials Research Report on Glioblastoma Multiforme
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion Lorlatinib, Lorlatinib with chemotherapy1, Lorlatinib with chemotherapy 2 - High Grade Glioma, Diffuse Intrinsic Pontine Glioma | Early Phase 1 | Recruiting | Nationwide Children's Hospital | 15 | 2025-08-03 | 2026-06-29 |
| Atezolizumab and Pre-Surgical Brain Radiation Therapy for Glioblastoma Multiforme Atezolizumab + FSRT radiation - Glioblastoma Multiforme | Early Phase 1 | Recruiting | Stony Brook University | 12 | 2022-10-25 | 2025-12-22 |
| Safety and Efficacy of TRPP Therapy in Glioblastoma Multiforme TMZ - Glioblastoma Multiforme | Early Phase 1 | Unknown | The Second Hospital of Hebei Medical University | 10 | 2022-10-01 | 2022-10-21 |
| Study of Tinostamustine for Adjuvant Treatment of Glioblastoma Tinostamustine - Glioblastoma Multiforme | Early Phase 1 | Completed | Mundipharma Research Limited | 10 | 2022-07-01 | 2025-12-10 |
| Multimodality MRI and Liquid Biopsy in GBM Post Feraheme Infusion MRI - Glioblastoma Multiforme, Brain Tumor, Adult: Glioblastoma | Early Phase 1 | Withdrawn | Abramson Cancer Center at Penn Medicine | 2022-06-01 | 2022-09-16 | |
| AZD1390 in Recurrent and Newly Diagnosed WHO Grade 4 Glioma Patients AZD1390 - Glioblastoma, Glioma | Early Phase 1 | Active not recruiting | Nader Sanai | 97 | 2022-05-27 | 2026-03-09 |
| Neuro-pharmacological Properties of Repurposed Posaconazole in Glioblastoma: A Phase 0 Clinical Trial Posaconazole Pill - Glioblastoma, Glioblastoma Multiforme | Early Phase 1 | Terminated | Milton S. Hershey Medical Center | 7 | 2022-05-13 | 2026-01-23 |
| Neuro-pharmacological Properties of Repurposed Ketoconazole in Glioblastomas Ketoconazole - Glioblastoma, Glioblastoma Multiforme | Early Phase 1 | Terminated | Milton S. Hershey Medical Center | 1 | 2022-05-11 | 2026-01-07 |
| Trial of Niraparib in Participants With Newly-diagnosed Glioblastoma and Recurrent Glioma Niraparib, Radiation therapy - Glioblastoma, Glioblastoma Multiforme | Early Phase 1 | Active not recruiting | Nader Sanai | 42 | 2021-10-29 | 2026-03-09 |
| Study of [68Ga]-FF58 in Patients With Selected Solid Tumors Expected to Overexpress αvβ3 and αvβ5 Integrins. 68Ga-FF58 - Glioblastoma Multiforme, Brain Neoplasms | Early Phase 1 | Terminated | Novartis Pharmaceuticals | 14 | 2021-10-14 | 2025-10-10 |
| Study of DSP-0390 in Patients With Recurrent High-Grade Glioma DSP-0390 - High Grade Glioma, Glioblastoma Multiforme | Early Phase 1 | Active not recruiting | Sumitomo Pharma America, Inc. | 39 | 2021-09-08 | 2026-07-29 |
| Study of Pamiparib in Newly Diagnosed and rGBM Pamiparib, Olaparib, Radiation therapy - Glioblastoma, Glioblastoma Multiforme | Early Phase 1 | Completed | Nader Sanai | 50 | 2021-01-11 | 2026-05-14 |
| Anti-Cancer Effects of Carvedilol With Standard Treatment in Glioblastoma and Response of Peripheral Glioma Circulating Tumor Cells Carvedilol - Glioblastoma, Glioblastoma Multiforme | Early Phase 1 | Withdrawn | West Virginia University | 2020-09-01 | 2021-04-12 | |
| Carvedilol With Chemotherapy in Second Line Glioblastoma and Response of Circulating Tumor Cells Carvedilol - Glioblastoma Multiforme, Glioblastoma | Early Phase 1 | Terminated | West Virginia University | 4 | 2019-07-19 | 2021-09-24 |
| A Phase 0/I Study of Ribociclib (LEE011) in Combination With Everolimus in Preoperative Recurrent High-Grade Glioma Patients Scheduled for Resection Ribociclib, Everolimus - Glioblastoma Multiforme, Glioma of Brain | Early Phase 1 | Completed | St. Joseph's Hospital and Medical Center, Phoenix | 27 | 2019-01-19 | 2025-05-30 |
| 5 Fraction Stereotactic Radiosurgery With Temozolomide for Glioblastoma Multiforme Temozolomide - Glioblastoma Multiforme | Early Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 3 | 2017-10-18 | 2021-11-19 |
| Adoptive Cell Therapy of Autologous TIL and PD1-TIL Cells for Patients With Glioblastoma Multiforme TIL, PD1-TIL - Glioblastoma Multiforme | Early Phase 1 | Unknown | Huashan Hospital | 40 | 2017-01-01 | 2021-08-25 |
| Ribociclib (LEE011) in Preoperative Glioma and Meningioma Patients Ribociclib - Glioblastoma Multiforme, Meningioma | Early Phase 1 | Active not recruiting | Nader Sanai | 48 | 2016-10-17 | 2026-03-06 |
| Exploratory Study of the Modulation of the Immune System by VEGF Blockade in Patients With Glioblastoma Multiforme (GBM) Bevacizumab - Glioblastoma Multiforme | Early Phase 1 | Completed | Dartmouth-Hitchcock Medical Center | 13 | 2010-03-01 | 2018-05-25 |
Glioblastoma (19) · Glioma (7) · Brain Neoplasms (6) · Astrocytoma (1) · Breast Neoplasms (1) · Diffuse Intrinsic Pontine Glioma (1) · Meningioma (1)
Neoplasms (19) · Neoplasms by Histologic Type (19) · Neoplasms, Germ Cell and Embryonal (19) · Neoplasms, Glandular and Epithelial (19) · Neoplasms, Nerve Tissue (19) · Neoplasms, Neuroepithelial (19) · Neuroectodermal Tumors (19) · Astrocytoma (18) · Glioma (12) · Central Nervous System Neoplasms (8) · Neoplasms by Site (8) · Nervous System Diseases (8) · Nervous System Neoplasms (8) · Brain Diseases (7) · Central Nervous System Diseases (7)
Carvedilol (2) · Radiotherapy (2) · Temozolomide (2) · ribociclib (2) · AZD1390 (1) · Bevacizumab (1) · Everolimus (1) · Ketoconazole (1) · atezolizumab (1) · lorlatinib (1) · niraparib (1) · olaparib (1) · pamiparib (1) · posaconazole (1) · tinostamustine (1)
Nader Sanai (4) · Milton S. Hershey Medical Center (2) · West Virginia University (2) · Abramson Cancer Center at Penn Medicine (1) · Dartmouth-Hitchcock Medical Center (1) · Huashan Hospital (1) · Mundipharma Research Limited (1) · Nationwide Children's Hospital (1) · Novartis Pharmaceuticals (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1) · St. Joseph's Hospital and Medical Center, Phoenix (1) · Stony Brook University (1) · Sumitomo Pharma America, Inc. (1) · The Second Hospital of Hebei Medical University (1)
United States (15) · China (2) · Germany (2) · Australia (1) · Canada (1) · France (1) · Japan (1) · Netherlands (1) · New Zealand (1) · Spain (1) · Switzerland (1)
Nader Sanai, MD (5) · Joanna Kolodney, MD (2) · Alexander Stessin, MD (1) · Alireza Mansouri (1) · Alireza Mansouri, MD (1) · Camilo E Fadul, MD (1) · Chunyan Li, Academician (1) · Hamza Gorsi, MD (1) · Jian Li, MD (1) · Lawrence Kleinberg, MD (1) · Maryam Fouladi, MD (1) · Seyed Ali Nabavizadeh, MD (1) · Susan Chi, MD (1) · Tomas Janik, MD (1)
PMID 35861778, PMID 38883740, PMID 41206763, PMID 42494994
R03CA255992 (1)