9 completed, 2 terminated, 2 withdrawn, 1 active not recruiting. 9 Phase 2, 5 Phase 1, 2 Not applicable, 1 Phase 3.
Follow Germ Cell Tumors: new trials by email Literature Review of Germ Cell Tumors trials Research Report on Germ Cell Tumors
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Hematological Malignances Cyclophosphamide, CAR.70/IL15-transduced CB-NK cells, Fludarabine phosphate - B-Cell Lymphoma, Myelodysplastic Syndromes (MDS) | Phase 1 / Phase 2 | Recruiting | M.D. Anderson Cancer Center | 80 | 2022-11-01 | 2026-08-07 |
| Aerosolized Azacytidine as Epigenetic Priming for Bintrafusp Alfa-Mediated Immune Checkpoint Blockade in Patients With Unresectable Pulmonary Metastases From Sarcomas, Germ Cell Tumors, or Epithelial Malignancies AeroEclipse II Breath Actuated Nebulizer, Bintrafusp alfa, Azacytidine - Sarcomas, Melanomas | Phase 1 / Phase 2 | Withdrawn | National Cancer Institute (NCI) | 2021-12-14 | 2021-12-17 | |
| Immunohistochemical Evaluation of Protein P16 Expression in Ovarian Germ Cell Tumors. p16INK4a Recombinant Rabbit Monoclonal Antibody (RM267), Ki67 antibody (DAKO) for malignant cases only - Ovarian Neoplasms, Germ Cell Tumors | Completed | Assiut University | 62 | 2019-12-24 | 2021-09-08 | |
| Nivolumab in Platinum Recurrent or Refractory Metastatic Germ Cell Tumors Nivolumab - Germ Cell Tumors | Phase 2 | Withdrawn | Hospital Beatriz Ângelo | 2018-10-01 | 2019-08-21 | |
| A Phase I Study of Lyso-thermosensitive Liposomal Doxorubicin and MR-HIFU for Pediatric Refractory Solid Tumors Magnetic resonance high intensity focused ultrasound, Lyso-thermosensitive liposomal doxorubicin - Pediatric Cancer, Solid Tumors | Phase 1 | Terminated | AeRang Kim | 2 | 2016-10-01 | 2023-08-29 |
| Brentuximab Vedotin in Relapsed/Refractory Germ Cell Tumors Brentuximab Vedotin - Germ Cell Tumors, Testis Cancer | Phase 2 | Terminated | Nabil Adra | 18 | 2016-03-09 | 2019-12-10 |
| Simvastatin With Topotecan and Cyclophosphamide in Relapsed and/or Refractory Pediatric Solid and CNS Tumors Simvastatin, Cyclophosphamide, Topotecan - Retinoblastoma, Clear Cell Sarcoma | Phase 1 | Completed | Emory University | 13 | 2015-02-01 | 2020-04-03 |
| Molecular-Guided Therapy for Childhood Cancer Guided Therapy - Neuroblastoma, Medulloblastoma | Not applicable | Completed | Giselle Sholler | 186 | 2014-07-08 | 2025-11-03 |
| Paclitaxel, Ifosfamide and Cisplatin (TIP) Versus Bleomycin, Etoposide and Cisplatin (BEP) for Patients With Previously Untreated Intermediate- and Poor-risk Germ Cell Tumors Paclitaxel, Ifosfamide, Cisplatin - Germ Cell Tumors | Phase 2 | Active not recruiting | Memorial Sloan Kettering Cancer Center | 92 | 2013-06-01 | 2026-08-06 |
| Pazopanib in Advanced and Cisplatin-resistant Germ Cell Tumors Pazopanib - Germ Cell Tumors, Measurable Disease | Phase 2 | Completed | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | 43 | 2013-05-17 | 2021-05-14 |
| Auto Transplant for High Risk or Relapsed Solid or CNS Tumors Ifosfamide, Etoposide, Mesna - Ewing's Family Tumors, Renal Tumors | Not applicable | Completed | Masonic Cancer Center, University of Minnesota | 44 | 2011-10-20 | 2024-02-26 |
| Dose Intensification Study in Refractory Germ Cell Tumors With Relapse and Bad Prognosis Paclitaxel, Ifosfamide, Carboplatine - Germ Cell Tumors | Phase 2 | Completed | Institut Claudius Regaud | 101 | 2009-03-13 | 2026-04-14 |
| Aprepitant + a 5HT3 + Dexamethasone in Patients With Germ Cell Tumors Aprepitant, Placebo - Germ Cell Tumors | Phase 3 | Completed | Hoosier Cancer Research Network | 69 | 2007-12-01 | 2016-04-06 |
| Recombinant Human Thrombopoietin in Children Receiving Ifosfamide, Carboplatin, and Etoposide Chemotherapy Recombinant Human Thrombopoietin - Germ Cell Tumors, Hepatic Cancer | Phase 1 / Phase 2 | Completed | St. Jude Children's Research Hospital | 40 | 2000-06-01 | 2008-04-10 |
| Conventional Dose Versus High Dose Sequential Chemotherapy for Poor Prognosis Germ Cell Tumors Cyclophosphamide, Etoposide, Cisplatin - Testicular Neoplasms, Germ Cell Tumors | Phase 2 | Completed | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | 1996-12-01 | 2014-06-12 |
Neoplasms, Germ Cell and Embryonal (15) · Rhabdomyosarcoma (5) · Carcinoma, Renal Cell (4) · Neuroblastoma (4) · Osteosarcoma (4) · Sarcoma (4) · Rhabdoid Tumor (3) · Sarcoma, Ewing (3) · Testicular Neoplasms (3) · Wilms Tumor (3) · Carcinoma, Hepatocellular (2) · Hepatoblastoma (2) · Medulloblastoma (2) · Retinoblastoma (2) · Sarcoma, Clear Cell (2)
Neoplasms by Histologic Type (15) · Neoplasms (14) · Neoplasms by Site (10) · Urogenital Diseases (9) · Urogenital Neoplasms (9) · Male Urogenital Diseases (8) · Female Urogenital Diseases (6) · Female Urogenital Diseases and Pregnancy Complications (6) · Neoplasms, Connective and Soft Tissue (6) · Neoplasms, Glandular and Epithelial (6) · Neoplasms, Nerve Tissue (6) · Neuroectodermal Tumors (6) · Adenocarcinoma (5) · Carcinoma (5) · Kidney Diseases (5)
Etoposide (4) · Carboplatin (3) · Cyclophosphamide (3) · Ifosfamide (3) · Paclitaxel (3) · Bleomycin (2) · Cisplatin (2) · Granulocyte Colony-Stimulating Factor (2) · Mesna (2) · Aprepitant (1) · Azacitidine (1) · Brentuximab Vedotin (1) · Busulfan (1) · Cytapheresis (1) · Leukapheresis (1)
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano (2) · AeRang Kim (1) · Assiut University (1) · Emory University (1) · Giselle Sholler (1) · Hoosier Cancer Research Network (1) · Hospital Beatriz Ângelo (1) · Institut Claudius Regaud (1) · M.D. Anderson Cancer Center (1) · Masonic Cancer Center, University of Minnesota (1) · Memorial Sloan Kettering Cancer Center (1) · Nabil Adra (1) · National Cancer Institute (NCI) (1) · St. Jude Children's Research Hospital (1)
United States (10) · Italy (2) · Egypt (1) · France (1) · Lebanon (1) · Portugal (1)
AeRang Kim, MD, PhD (1) · Andrea Necchi, MD (1) · Ashish Gupta, MBBS, MPH (1) · Costantine Albany, MD (1) · Darren Feldman, MD (1) · David Marin, MD (1) · David S Schrump, M.D. (1) · Giselle Sholler, MD (1) · Kelly Goldsmith, MD (1) · Lawrence Einhorn, M.D. (1) · Najat C. Daw, M.D. (1) · Omar Ahmed, Master (1)
PMID 31401903, PMID 22915652, PMID 25344361, PMID 33675184, PMID 38347552, PMID 41144785