7 recruiting, 6 completed, 2 unknown. 7 Phase 2, 3 Phase 1, 2 Not applicable, 1 Early Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Recruiting 4, Completed 2, Unknown 1 |
| Phase 1 | 3 | Completed 2, Recruiting 1 |
| Not applicable | 2 | Completed 1, Recruiting 1 |
| Early Phase 1 | 1 | Recruiting 1 |
| Phase 3 | 1 | Unknown 1 |
| Phase 4 | 1 | Unknown 1 |
Follow Evans Syndrome: new trials by email Literature Review of Evans Syndrome trials Research Report on Evans Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Assess the Tolerability of Ianalumab (VAY736) With Investigator's Choice Thrombopoietin Receptor Agonist (IC TPO-RA) in Patients With Primary Immune Thrombocytopenia (ITP) ianalumab, thrombopoietin receptor agonist (TPO-RA) - Primary Immune Thrombocytopenia (ITP), Primary Evans Syndrome (ES) | Phase 2 | Recruiting | Novartis Pharmaceuticals | 164 | 2026-08-04 | 2026-10-22 |
| UCAR-T Targeting CD19/BCMA in Subjects With Autoantibody-Mediated Autoimmune Benign Hematological Diseases CART Infusion - Autoimmune Hemolytic Anemia, Primary Immune Thrombocytopenic Purpura | Early Phase 1 | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 27 | 2026-02-03 | 2026-03-02 |
| A Study of CM336 in Patients With Relapsed or Refractory Autoimmune Cytopenia CM336 Injection - Autoimmune Cytopenia, Immune Thrombocytopenia (ITP) | Phase 1 / Phase 2 | Recruiting | Keymed Biosciences Co.Ltd | 158 | 2025-11-18 | 2025-12-17 |
| Anti-CD38 Antibody Treating Evans Syndrome Anti-CD38 antibody Injection - Evan Syndrome, Treatment | Phase 2 | Recruiting | Institute of Hematology & Blood Diseases Hospital, China | 10 | 2023-12-01 | 2025-02-21 |
| Sirolimus in the Treatment of Refractory/Relapsed wAIHA Sirolimus - Warm Autoimmune Hemolytic Anemia | Not applicable | Recruiting | Peking Union Medical College Hospital | 22 | 2023-06-24 | 2025-08-08 |
| Avatrombopag in the Treatment of Adult Immune Thrombocytopenia With Autoantibodies Avatrombopag - Immune Thrombocytopenia, Autoantibodies | Phase 2 | Recruiting | Institute of Hematology & Blood Diseases Hospital, China | 52 | 2021-09-01 | 2025-02-24 |
| TPO-RAs Combined With Anti-CD20 Antibody in the Treatment of Adult Immune Thrombocytopenia With Autoantibodies Combined use of TPO-RAs with low-dose anti-CD20 antibody, The best available therapy - Immune Thrombocytopenia (ITP), Autoantibodies | Phase 2 / Phase 3 | Unknown | Institute of Hematology & Blood Diseases Hospital, China | 94 | 2021-06-06 | 2024-07-03 |
| Single-dose Anti-CD20 Antibody With Bortezomib for Relapsed Refractory Autoimmune Hemolytic Anemia combination of a single dose anti-CD20 antibody and bortezomib - Autoimmune Hemolytic Anemia, Autoimmune Hemolytic Anemia and Autoimmune Thrombocytopenia | Phase 2 | Completed | Peking Union Medical College Hospital | 33 | 2019-08-20 | 2024-04-26 |
| Autoimmune Cytopenia: Genetics and Pathophysiological Mechanism in Pediatric Evans Syndrome blood sample - Evans Syndrome | Not applicable | Completed | University Hospital, Bordeaux | 374 | 2019-07-05 | 2026-07-06 |
| Tacrolimus Treatment for Refractory Autoimmune Cytopenia Tacrolimus - Autoimmune Hemolytic Anemia, Pure Red Cell Aplasia | Phase 4 | Unknown | Peking Union Medical College Hospital | 80 | 2019-05-04 | 2019-12-03 |
| Severe Immune Cytopenia Registry Www.Sic-reg.Org potential biomarkers - Immune Thrombocytopenia, Autoimmune Hemolytic Anemia | Completed | Medical University of Graz | 80 | 2018-03-09 | 2025-11-21 | |
| Balance Benefit / Risk of Immunomodulatory Treatments at the Child and Adolescent for Autoimmune Cytopenia. Immune Thrombocytopenic Purpura, Autoimmune Hemolytic Anemia | Completed | University Hospital, Bordeaux | 454 | 2016-01-18 | 2019-08-15 | |
| OBS'CEREVANCE: French Cohort of Pediatric Autoimmune Cytopenia data collection - Immune Thrombocytopenia, Autoimmune Hemolytic Anemia | Recruiting | University Hospital, Bordeaux | 3500 | 2010-09-01 | 2023-07-10 | |
| Sirolimus for Autoimmune Disease of Blood Cells sirolimus - Autoimmune Pancytopenia, Autoimmune Lymphoproliferative Syndrome (ALPS) | Phase 1 / Phase 2 | Completed | Children's Hospital of Philadelphia | 30 | 2006-12-01 | 2019-11-19 |
| Treatment of Autoimmune Thrombocytopenia (AITP) Isolex 300i - Autoimmune Disease, Autoimmune Hemolytic Anemia | Phase 1 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 29 | 1997-07-21 | 2017-07-02 |
Anemia, Hemolytic, Autoimmune (9) · Purpura, Thrombocytopenic, Idiopathic (8) · Connective Tissue Diseases (2) · Recurrence (2) · Anemia, Aplastic (1) · Anemia, Hemolytic (1) · Arthritis, Rheumatoid (1) · Autoimmune Diseases (1) · Autoimmune Lymphoproliferative Syndrome (1) · Cytopenia (1) · Inflammatory Bowel Diseases (1) · Lupus Erythematosus, Systemic (1) · Myelodysplastic Syndromes (1) · Neutropenia (1)
Hematologic Diseases (12) · Hemic and Lymphatic Diseases (12) · Immune System Diseases (12) · Autoimmune Diseases (11) · Pathologic Processes (10) · Pathological Conditions, Signs and Symptoms (10) · Anemia (9) · Blood Platelet Disorders (9) · Anemia, Hemolytic (8) · Blood Coagulation Disorders (8) · Cytopenia (8) · Hemorrhage (8) · Hemorrhagic Disorders (8) · Purpura (8) · Purpura, Thrombocytopenic (8)
Sirolimus (2) · avatrombopag (2) · Blood Specimen Collection (1) · Bortezomib (1) · Data Collection (1) · Injections (1) · Rituximab (1) · Tacrolimus (1) · eltrombopag (1) · ianalumab (1) · romiplostim (1)
Institute of Hematology & Blood Diseases Hospital, China (3) · Peking Union Medical College Hospital (3) · University Hospital, Bordeaux (3) · Children's Hospital of Philadelphia (1) · Keymed Biosciences Co.Ltd (1) · Medical University of Graz (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · Novartis Pharmaceuticals (1) · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (1)
China (8) · United States (3) · France (2) · Austria (1)
Bing Han (1) · Bing Hang, PhD (1) · David T. Teachey, MD (1) · Lei Zhang, M.D (1) · Lei Zhang, M.D. (1) · Lei Zhang, MD (1) · Rongfeng Fu (1)
PMID 19208097, PMID 26504182, PMID 30940614, PMID 38227934, PMID 42263666