7 recruiting, 2 completed, 2 not yet recruiting, 2 unknown. 6 Not applicable, 3 Phase 3, 2 Phase 2, 1 Early Phase 1, 1 Phase 4.
Follow Endometrial Cancer Stage I: new trials by email Literature Review of Endometrial Cancer Stage I trials Research Report on Endometrial Cancer Stage I
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Semaglutide, Weight Loss, and LNG-IUD for Conservative Treatment of Endometrial Atypical Hyperplasia and Grade 1 Endometrial Cancer Semaglutide (Wegovy) weekly injection, LNG-IUD (Progestin), Structured Weight Loss Program - Endometrial Atypical Hyperplasia, Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia | Phase 2 | Not yet recruiting | The Methodist Hospital Research Institute | 48 | 2027-01-01 | 2026-10-01 |
| SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer GLP-1 Receptor Agonist, Levonorgestrel IUD (Lng-IUD), Oral Progestins - Endometrial Cancer, Endometrial Cancer Stage I | Phase 4 | Not yet recruiting | Hospital Universitari de Bellvitge | 80 | 2027-01-01 | 2026-06-10 |
| Comparison of Two-Position and Four-Position Cervical Injection Techniques for Sentinel Lymph Node Mapping in Endometrial Cancer Using Methylene Blue Sentinel Lymph Node Detection/Cervical Methylene Blue Injection - Endometrial Neoplasms, Endometrial Cancer Stage I | Not applicable | Recruiting | Dokuz Eylul University | 100 | 2025-05-01 | 2025-06-27 |
| SATELLITE Study (feaSibility sAfeTy Efficacy dostarLimab earLy-stage defIcient endomeTrial cancEr) Dostarlimab-Gxly 50 MG/1 ML Intravenous Solution [JEMPERLI] - Endometrial Cancer Stage I, Mmr Deficiency | Phase 2 | Recruiting | Queensland Centre for Gynaecological Cancer | 10 | 2024-08-01 | 2024-12-03 |
| Prospective Study for Endometrial Carcinoma and Hyperplasia in Childbearing-age Women Megestrol Acetate 40 MG - Endometrial Cancer Stage I, Endometrial Hyperplasia | Not applicable | Recruiting | Women's Hospital School Of Medicine Zhejiang University | 75 | 2023-12-01 | 2024-05-16 |
| PROfiling Based Endometrial Cancer Adjuvant Therapy Vaginal brachytherapy, External beam radiotherapy, Observation - Endometrial Cancer Stage I, Endometrial Cancer Stage II | Not applicable | Recruiting | Women's Hospital School Of Medicine Zhejiang University | 590 | 2022-01-24 | 2025-04-01 |
| Concurrent Laparoscopic Hysterectomy and Weight Loss Surgery in Obese Patients With Endometrial Carcinoma or Endometrial Intraepithelial Neoplasia CONCURRENT LAPAROSCOPIC HYSTERECTOMY AND WEIGHT LOSS SURGERY-Referral - Endometrial Carcinoma, Obesity | Not applicable | Recruiting | Dana-Farber Cancer Institute | 30 | 2021-08-01 | 2026-08-31 |
| [SENTRY] Tailoring Postoperative Management Through Sentinel Lymph Node Biopsy in Low- and Intermediate-Risk Endometrial Cancer Laparoscopic total hysterectomy with bilateral salpingo-oophorectomy and sentinel lymph node biopsy - Endometrial Cancer, Endometrial Neoplasms | Not applicable | Completed | Moscow City Oncology Hospital No. 62 | 102 | 2021-07-01 | 2024-05-07 |
| Clinical Effects of Metformin on Fertility-sparing Treatment for Early Endometrial Cancer Metformin - Endometrial Cancer Stage I | Phase 3 | Unknown | Samsung Medical Center | 77 | 2021-06-01 | 2023-04-13 |
| Sentinel Node Biopsy in Endometrial Cancer TH BSO with SNB Note: If participants (≤45yo), Grade 1 endometrial adenocarcinoma with myometrial invasion <50%, wish to retain their ovaries a BSO may be omitted, TH BSO without retroperitoneal node dissection Note: If participants (≤45yo), Grade 1 endometrial adenocarcinoma with myometrial invasion <50%, wish to retain their ovaries a BSO may be omitted - Endometrial Cancer Stage I, Sentinel Lymph Node | Phase 3 | Recruiting | Queensland Centre for Gynaecological Cancer | 760 | 2021-01-18 | 2026-09-15 |
| Observational Study of Women With Endometrial Cancer Who Receive the Standard Treatment for Their Disease Physical exam - Endometrial Cancer, Endometrioid Adenocarcinoma | Recruiting | Memorial Sloan Kettering Cancer Center | 1715 | 2020-02-26 | 2026-08-07 | |
| Programmed Death-1(PD-1) Inhibitor Combined With Progesterone Treatment in Endometrial Cancer PD-1 inhibitor combined progesterone, progesterone - Endometrial Cancer Stage I | Early Phase 1 | Unknown | Shanghai First Maternity and Infant Hospital | 60 | 2019-10-01 | 2019-08-06 |
| Cost-utility of Ambulatory Surgery in the Management of Endometrial Cancer(AMBU-ENDO) ambulatory surgery, standard surgery - Endometrial Cancer Stage I, Endometrial Cancer Stage II | Not applicable | Completed | Assistance Publique - Hôpitaux de Paris | 77 | 2018-08-01 | 2022-12-13 |
| PORTEC-4a: Molecular Profile-based Versus Standard Adjuvant Radiotherapy in Endometrial Cancer Vaginal brachytherapy, External beam radiotherapy, Observation - Endometrial Cancer Stage I, Endometrial Cancer Stage II | Phase 3 | Active not recruiting | Leiden University Medical Center | 550 | 2016-06-10 | 2023-10-11 |
Endometrial Neoplasms (14) · Endometrial Hyperplasia (4) · Obesity (3) · Overweight (2) · Carcinoma, Endometrioid (1) · Neoplasm Metastasis (1) · Neoplasms (1) · Turcot syndrome (1) · Uterine Neoplasms (1) · Weight Loss (1)
Female Urogenital Diseases (14) · Female Urogenital Diseases and Pregnancy Complications (14) · Genital Diseases (14) · Genital Diseases, Female (14) · Genital Neoplasms, Female (14) · Neoplasms by Site (14) · Urogenital Diseases (14) · Urogenital Neoplasms (14) · Uterine Diseases (14) · Neoplasms (13) · Uterine Neoplasms (13) · Pathological Conditions, Signs and Symptoms (4) · Body Weight (3) · Nutrition Disorders (3) · Nutritional and Metabolic Diseases (3)
Megestrol Acetate (2) · Observation (2) · semaglutide (2) · Ambulatory Surgical Procedures (1) · Estrogen Replacement Therapy (1) · Hysterectomy (1) · Hysteroscopy (1) · Magnetic Resonance Spectroscopy (1) · Medroxyprogesterone Acetate (1) · Metformin (1) · Neoadjuvant Therapy (1) · Nutrition Assessment (1) · Progesterone (1) · Progestins (1) · Resistance Training (1)
Queensland Centre for Gynaecological Cancer (2) · Women's Hospital School Of Medicine Zhejiang University (2) · Assistance Publique - Hôpitaux de Paris (1) · Dana-Farber Cancer Institute (1) · Dokuz Eylul University (1) · Hospital Universitari de Bellvitge (1) · Leiden University Medical Center (1) · Memorial Sloan Kettering Cancer Center (1) · Moscow City Oncology Hospital No. 62 (1) · Samsung Medical Center (1) · Shanghai First Maternity and Infant Hospital (1) · The Methodist Hospital Research Institute (1)
United States (4) · Australia (2) · China (2) · Czechia (2) · France (2) · Italy (2) · Argentina (1) · Austria (1) · Belgium (1) · Brazil (1) · Colombia (1) · Germany (1) · Ireland (1) · Netherlands (1) · Norway (1)
Andreas Obermair, Prof (1) · Andreas Obermair, Professor (1) · Anne-Sophie van den Heerik, MD (1) · Aparna A. Kamat, MD (1) · Carien L. Creutzberg, MD, PhD (1) · Colleen Feltmate, MD (1) · Jeong-Won Lee, M.D., Ph.D. (1) · Jorge Garcia Fernandez (1) · Lola Marti (1) · Nadeem Abu-Rustum, MD (1) · Remi A. Nout, MD, PhD (1) · Xinyu Wang, MD (1) · Yang Li, Doctor (1)
PMID 30078506, PMID 32699021, PMID 33046573, PMID 34540651, PMID 34728527, PMID 36659832, PMID 38697821, PMID 39955187, PMID 41449145