10 completed, 4 recruiting, 3 not yet recruiting, 3 terminated. 9 Phase 2, 9 Phase 3, 6 Phase 4, 1 Early Phase 1, 1 Not applicable.
Follow Progestins: new trials by email Literature Review of Progestins trials Research Report on Progestins
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer GLP-1 Receptor Agonist, Levonorgestrel IUD (Lng-IUD), Oral Progestins - Endometrial Cancer, Endometrial Cancer Stage I | Phase 4 | Not yet recruiting | Hospital Universitari de Bellvitge | 80 | 2027-01-01 | 2026-06-10 |
| Orlistat Plus Progestin for Fertility-Sparing Treatment of Endometrial Cancer or Atypical Hyperplasia Orlistat, Progestin - Endometrial Neoplasms, Endometrial Cancer | Phase 2 | Not yet recruiting | Peking University People's Hospital | 48 | 2026-07-01 | 2026-07-20 |
| Refining Adjuvant Treatment IN Endometrial Cancer Based On Molecular Features (RAINBO) - NSMP-ORANGE Trial: Comparing Radiotherapy With Oral Progestin Tablets vs. the Current Standard Care, Radiotherapy and Chemotherapy, in Patients With NSMP Endometrial Cancer medroxyprogesterone acetate tablets OR megestrol acetate, Cisplatin, Carboplatin + Paclitaxel - Endometrial Cancer, Uterine Neoplasms | Phase 3 | Recruiting | University College, London | 600 | 2026-06-29 | 2026-09-21 |
| Intrauterine Injection of Type III Collage in FST of EC/AEH Recombinant Humanized Type III Collagen Lyophilized Fibers + High-dose Progestin, High-dose Progestin - Atypical Endometrial Hyperplasia, Endometrial Cancer | Phase 2 | Recruiting | Wang Jianliu | 30 | 2026-01-30 | 2026-03-30 |
| Sleeping Through Menopause Estrogens and Progestogens, Cognitive behavioral therapy for insomnia (CBTi), and circadian rhythm therapy - Menopause, Insomnia | Phase 4 | Not yet recruiting | VU University of Amsterdam | 222 | 2025-10-01 | 2025-08-24 |
| TQB2450 Plus Progestin for Fertility-sparing Treatment in MMRd EC TQB2450 injection + oral progestin - Endometrial Cancer | Phase 2 | Recruiting | Fudan University | 10 | 2025-04-21 | 2026-06-04 |
| Primary Prevention and Uterine Preservation in Premenopausal Women With Obesity and Endometrial Hyperplasia Semaglutide, Placebo, LNG-IUD (Progestin) - Endometrial Hyperplasia | Phase 2 | Withdrawn | Washington University School of Medicine | 2025-03-12 | 2026-01-12 | |
| Uterine Preservation Via Lifestyle Transformation Telemedicine behavioral weight intervention, Progestin, Enhanced usual care - Endometrial Hyperplasia, Grade 1 Endometrial Cancer | Phase 2 | Recruiting | Washington University School of Medicine | 96 | 2024-10-24 | 2026-01-20 |
| Comparison of Progestin Primed Ovarian Stimulation (PPOS) vs.GnRH Antagonist Methods on IVF Outcomes Progestin, GnRH antagonist - IVF, Fertility Issues | Phase 4 | Unknown | Nesta Clinic | 152 | 2024-08-01 | 2024-07-17 |
| Natural Progesterone for the Treatment of Recurrent Glioblastoma Quality-of-Life Assessment, Questionnaire Administration, Therapeutic Progesterone - Gliosarcoma, Recurrent Glioblastoma | Early Phase 1 | Terminated | Emory University | 4 | 2022-04-11 | 2026-05-05 |
| Treat of Functional Ovarian Cysts by Compare Between Cocs and Progesterone Only Pills Combined Oral Contraceptive, Progestin - Ovarian Neoplasms | Phase 3 | Unknown | Sohag University | 60 | 2022-02-20 | 2022-02-17 |
| Maternal and Newborn Safety Profile of Progestogens in EARLY Pregnancy Progestagen - Early Pregnancy Bleeding, Recurrent Pregnancy Loss | Terminated | Center for Epidemiology and Health Research, Germany | 50 | 2021-12-15 | 2023-08-14 | |
| Regulation of Cervical Mucus Secretion Leuprolide acetate, Estrogen and Progesterone Replacement, Progestin - Fertility, Contraception | Phase 4 | Completed | Oregon Health and Science University | 5 | 2015-03-29 | 2019-10-18 |
| Progestin-induced Endometrial Shedding in PCOS (The PIES in PCOS Study) Progestin, Clomiphene Citrate - Polycystic Ovary Syndrome, Infertility | Not applicable | Terminated | University of Illinois at Chicago | 27 | 2015-03-01 | 2020-09-29 |
| Vaginal Progesterone in Twins With Short Cervix Vaginal Progesterone gel., fetal fibronectin swab., Placebo gel - Premature Birth | Phase 2 / Phase 3 | Withdrawn | Obstetrix Medical Group | 2014-03-01 | 2014-12-19 | |
| Effect of Progestin-Induced Withdrawal Bleed on Ovulation Induction Cycles With Clomiphene Citrate Progestin - Polycystic Ovary Syndrome, Infertility | Phase 4 | Withdrawn | University of British Columbia | 2013-10-01 | 2014-11-06 | |
| Estriol Treatment in Multiple Sclerosis (MS): Effect on Cognition estriol, Placebo, Norethindrone - Relapsing-remitting Multiple Sclerosis, Secondary-progressive Multiple Sclerosis | Phase 2 | Unknown | University of California, Los Angeles | 64 | 2011-10-01 | 2019-11-06 |
| PGL4001 Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata (PEARLIII-extension Study) PGL4001, placebo, drug free period, PGL4001, progestin, drug free period - Uterine Fibroids | Phase 3 | Completed | PregLem SA | 132 | 2011-01-01 | 2016-01-13 |
| PGL4001 Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata PGL4001, placebo, PGL4001, progestin - Uterine Fibroids | Phase 3 | Completed | PregLem SA | 209 | 2010-07-01 | 2016-01-15 |
| Efficacy and Safety of Estradiol and Progesterone Microspheres for the Treatment of Climacteric Symptoms. Estradiol and Progesterone - Menopause | Phase 2 / Phase 3 | Completed | Centro A.F. de Estudios Tecnologicos, S.A. | 103 | 2007-04-01 | 2009-08-25 |
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Endometrial Hyperplasia (6) · Endometrial Neoplasms (6) · Infertility (3) · Cardiovascular Diseases (2) · Coronary Disease (2) · Heart Diseases (2) · Leiomyoma (2) · Myocardial Ischemia (2) · Obesity (2) · Osteoporosis (2) · Polycystic Ovary Syndrome (2) · Adenomyosis (1) · Anorexia Nervosa (1) · Anovulation (1) · Bone Diseases (1)
National Heart, Lung, and Blood Institute (NHLBI) (2) · PregLem SA (2) · Washington University School of Medicine (2) · Boston Children's Hospital (1) · Center for Epidemiology and Health Research, Germany (1) · Centro A.F. de Estudios Tecnologicos, S.A. (1) · Emory University (1) · Fudan University (1) · Hospital Universitari de Bellvitge (1) · Nesta Clinic (1) · Obstetrix Medical Group (1) · Oregon Health and Science University (1) · Peking University People's Hospital (1) · Sohag University (1) · Taipei Veterans General Hospital, Taiwan (1)
United States (7) · China (3) · Austria (2) · Belgium (2) · Poland (2) · Spain (2) · Canada (1) · Germany (1) · Mexico (1) · Norway (1) · Taiwan (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Andrea R Hagemann, M.D., MSCI (2) · Albert Asante, MD, MPH (1) · Andrew Combs, MD (1) · Birit Broekman, Prof. (1) · Catherine M. Gordon, MD (1) · Clare Barnet (1) · David Herrington (1) · Ercan Bastu, M.D. (1) · Eus van Someren, Prof. (1) · Hui-Kuo G Shu, MD, PhD, FASTRO (1) · Jon Havelock, MD (1) · Jorge Garcia Fernandez (1) · Leo Han, MD (1) · Lola Marti (1)
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P30CA138292 (1), P50CA265793 (1), R01HD043869 (1), U01HL049488 (1)