19 completed. 19 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 19 | Completed 19 |
Follow Drug Interaction Potentiation: new trials by email Literature Review of Drug Interaction Potentiation trials Research Report on Drug Interaction Potentiation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Evaluate Pharmacokinetic Drug Interactions and Safety of Ilaprazole and Aceclofenac Ilaprazole, Aceclofenac - Drug Interaction Potentiation | Phase 1 | Completed | Il-Yang Pharm. Co., Ltd. | 24 | 2022-11-10 | 2023-06-28 |
| Study to Evaluate Pharmacokinetic Drug Interactions and Safety of Naproxen, Aceclofenac, Celecoxib and Ilaprazole Ilaprazole, Naproxen, Aceclofenac - Drug Interaction Potentiation | Phase 1 | Completed | Il-Yang Pharm. Co., Ltd. | 72 | 2022-02-17 | 2023-06-28 |
| Doravirine, Rifapentine and Isoniazid Interaction Doravirine (DOR), Rifapentine (RPT), Isoniazid (INH) - Latent Tuberculosis, Human Immunodeficiency Virus | Phase 1 | Completed | Walter K. Kraft | 11 | 2019-04-22 | 2020-03-27 |
| Study to Evaluate the Effect of Rabeprazole on the Pharmacokinetics of Vadadustat Vadadustat, Rabeprazole - Drug Interaction Potentiation, Pharmacokinetics | Phase 1 | Completed | Akebia Therapeutics | 20 | 2018-10-03 | 2019-03-22 |
| Drug-Drug Interaction Study of Vadadustat With Digoxin, Adefovir and Furosemide Vadadustat, Furosemide, Adefovir - Drug Interaction Potentiation | Phase 1 | Completed | Akebia Therapeutics | 62 | 2018-07-20 | 2019-03-22 |
| Drug-Drug Interaction Study of Vadadustat With Cyclosporine, Probenecid and Rifampin vadadustat, Rifampin, Probenecid - Drug Interaction Potentiation | Phase 1 | Completed | Akebia Therapeutics | 40 | 2018-07-20 | 2019-03-22 |
| Drug-Drug Interaction Study of Vadadustat With Rosuvastatin, Sulfasalazine, Pravastatin, Atorvastatin and Simvastatin Vadadustat, Simvastatin, Rosuvastatin - Drug Interaction Potentiation | Phase 1 | Completed | Akebia Therapeutics | 134 | 2018-06-17 | 2019-03-22 |
| A Fixed-Sequence, Drug-Drug Interaction Study Between Multiple Oral Doses of Inarigivir Soproxil and a Single Oral Dose of Midazolam in Healthy Subjects Midazolam, Inarigivir - Drug Interaction Potentiation | Phase 1 | Completed | F-star Therapeutics, Inc. | 17 | 2018-05-07 | 2020-10-08 |
| Mifepristone Drug-Drug Interaction Study With CYP3A Inhibitor Mifepristone 300 MG, Itraconazole 100 MG - Drug Interaction Potentiation, Healthy | Phase 1 | Completed | Corcept Therapeutics | 33 | 2017-08-09 | 2018-02-22 |
| Open-label, Single Center, Non-randomized, Fixed Sequence Phase 1 Drug-drug Interaction Study With LEO 32731 and Midazolam LEO 32731, Midazolam - Drug Interaction Potentiation | Phase 1 | Completed | LEO Pharma | 32 | 2017-05-31 | 2017-11-14 |
| Study to Evaluate Pharmacokinetic Drug Interactions and Safety of Clarithromycin, Amoxicillin and Ilaprazole Ilaprazole 10mg, Clarithromycin 500mg, Amoxicillin 500 Mg - Drug Interaction Potentiation | Phase 1 | Completed | Il-Yang Pharm. Co., Ltd. | 28 | 2016-12-01 | 2017-01-26 |
| Pharmacokinetic Interaction Between Trospium With an Inhibitor of OCT1 and of P-gp in Subjects Genotyped for OCT1 intravenous infusion of 2 mg trospium chloride, oral administration of 30 mg trospium chloride, oral administration of 300 mg ranitidine - Pharmacokinetics, Inhibition Enzyme | Phase 1 | Completed | Dr. R. Pfleger Chemische Fabrik GmbH | 24 | 2016-11-01 | 2017-04-10 |
| A Drug-Drug Interaction Study of N91115 +/- Rifampin in Healthy Adult Subjects N91115, Rifampin - Drug Interaction Potentiation | Phase 1 | Completed | Nivalis Therapeutics, Inc. | 15 | 2015-06-01 | 2016-11-07 |
| Pharmacokinetic Interaction Study of Dapoxetine 30mg and Mirodenafil 100mg Dapoxetine 30mg, Mirodenafil 100mg - Drug Interaction Potentiation | Phase 1 | Completed | SK Chemicals Co., Ltd. | 36 | 2014-11-01 | 2015-06-30 |
| Pharmacokinetic Interaction Study of Dapoxetine 30mg and Mirodenafil 50mg Dapoxetine 30mg tablet, Mirodenafil 50mg tablet - Drug Interaction Potentiation | Phase 1 | Completed | SK Chemicals Co., Ltd. | 36 | 2013-10-01 | 2015-06-30 |
| A Drug-Drug Interaction Study of Digoxin and PA21 PA21, Digoxin - Drug Interaction Potentiation | Phase 1 | Completed | Vifor Pharma | 42 | 2011-11-01 | 2012-01-18 |
| A Drug-Drug Interaction Study of Warfarin and PA21 PA21, Warfarin - Drug Interaction Potentiation | Phase 1 | Completed | Vifor Pharma | 45 | 2011-11-01 | 2012-02-16 |
| A Drug-Drug Interaction Study of Losartan and PA21 PA21 and Losartan with Food, No PA21; Losartan with food, PA21 with food and Losartan 2 hours later - Drug Interaction Potentiation | Phase 1 | Completed | Vifor Pharma | 36 | 2011-03-01 | 2012-12-21 |
| Drug-drug Interaction Study in Healthy Male Volunteers Following the Administration of Pantoprazole and Rosuvastatin Rosuvastatin, Pantoprazole - Drug Interaction Potentiation | Phase 1 | Completed | Centre hospitalier de l'Université de Montréal (CHUM) | 16 | 2010-04-01 | 2011-12-15 |
Acquired Immunodeficiency Syndrome (1) · Latent Tuberculosis (1)
Actinomycetales Infections (1) · Bacterial Infections (1) · Bacterial Infections and Mycoses (1) · Blood-Borne Infections (1) · Communicable Diseases (1) · Genital Diseases (1) · Gram-Positive Bacterial Infections (1) · HIV Infections (1) · Immune System Diseases (1) · Immunologic Deficiency Syndromes (1) · Infections (1) · Latent Infection (1) · Lentivirus Infections (1) · Mycobacterium Infections (1) · RNA Virus Infections (1)
vadadustat (4) · ilaprazole (3) · Clarithromycin (2) · Digoxin (2) · Midazolam (2) · Rifampin (2) · Rosuvastatin Calcium (2) · aceclofenac (2) · dapoxetine (2) · mirodenafil (2) · Amoxicillin (1) · Atorvastatin (1) · Celecoxib (1) · Cyclosporins (1) · Drugs, Generic (1)
Akebia Therapeutics (4) · Il-Yang Pharm. Co., Ltd. (3) · Vifor Pharma (3) · SK Chemicals Co., Ltd. (2) · Centre hospitalier de l'Université de Montréal (CHUM) (1) · Corcept Therapeutics (1) · Dr. R. Pfleger Chemische Fabrik GmbH (1) · F-star Therapeutics, Inc. (1) · LEO Pharma (1) · Nivalis Therapeutics, Inc. (1) · Walter K. Kraft (1)
United States (6) · Canada (5) · South Korea (3) · Germany (1) · Netherlands (1)
Minsoo Park, PhD (2) · Ada Lee, MD (1) · Christopher Galloway, MD (1) · Jae-Wook Ko, MD, PhD (1) · Jeroen van de Wetering (1) · Manuela Koch, MD (1) · Min MS Park, PhD (1) · Min-Gul Kim, MD, PhD (1) · Pavel Hamet, M.D., Ph.D. (1) · Peter J Winkle, MD (1) · Peter Winkle, MD (1) · Sandra K Willsie, MD (1) · Walter K Kraft, MD (1)
2016 (1), 2018 (1)