61 completed, 7 terminated, 2 withdrawn, 1 active not recruiting. 36 Phase 2, 23 Phase 1, 9 Not applicable, 7 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 36 | Completed 31, Terminated 4, Withdrawn 1 |
| Phase 1 | 23 | Completed 21, Terminated 2 |
| Not applicable | 9 | Completed 7, Terminated 1, Withdrawn 1 |
| Phase 3 | 7 | Completed 7 |
Follow de Novo Myelodysplastic Syndromes: new trials by email Literature Review of de Novo Myelodysplastic Syndromes trials Research Report on de Novo Myelodysplastic Syndromes
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Organ-Sparing Marrow-Targeted Irradiation Before Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies radiation therapy, cyclophosphamide, anti-thymocyte globulin - Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission | Phase 1 | Completed | Sumithira Vasu | 33 | 2015-07-27 | 2023-09-21 |
| CPX-351 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome liposomal cytarabine-daunorubicin CPX-351 - Adult Acute Erythroid Leukemia (M6), Adult Acute Megakaryoblastic Leukemia (M7) | Phase 2 | Completed | Rondeep Brar | 11 | 2014-02-03 | 2019-01-22 |
| Single or Double Donor Umbilical Cord Blood Transplant in Treating Patients With High-Risk Hematologic Malignancies cyclophosphamide, fludarabine phosphate, mycophenolate mofetil - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 2 | Withdrawn | University of Medicine and Dentistry of New Jersey | 2014-01-01 | 2016-07-14 | |
| Sirolimus and Azacitidine in Treating Patients With High Risk Myelodysplastic Syndrome or Acute Myeloid Leukemia That is Recurrent or Not Eligible for Intensive Chemotherapy Sirolimus, Azacitidine - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q) | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 57 | 2013-07-08 | 2025-12-10 |
| Decitabine and Total-Body Irradiation Followed By Donor Bone Marrow Transplant and Cyclophosphamide in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia decitabine, fludarabine phosphate, busulfan - Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | University of Wisconsin, Madison | 20 | 2013-05-16 | 2019-11-21 |
| Idarubicin, Cytarabine, and Pravastatin Sodium in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes pravastatin sodium, idarubicin, cytarabine - Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Not applicable | Completed | Fred Hutchinson Cancer Center | 24 | 2013-05-01 | 2017-11-17 |
| Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies therapeutic allogeneic lymphocytes, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Phase 2 | Completed | University of Chicago | 77 | 2013-04-04 | 2019-08-07 |
| Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell Transplant tetanus-CMV fusion peptide vaccine, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 | Completed | City of Hope Medical Center | 36 | 2012-10-29 | 2024-04-02 |
| Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem Cell Transplant management of therapy complications, musculoskeletal complications management/prevention - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Withdrawn | Roswell Park Cancer Institute | 2012-05-01 | 2012-07-09 | |
| Tosedostat in Combination With Cytarabine or Decitabine in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome tosedostat, cytarabine, decitabine - Acute Myeloid Leukemia With Multilineage Dysplasia, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Phase 2 | Completed | Fred Hutchinson Cancer Center | 34 | 2012-05-01 | 2017-02-15 |
| Rasburicase and Allopurinol in Treating Patients With Hematologic Malignancies rasburicase, allopurinol - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q) | Phase 2 | Terminated | Roswell Park Cancer Institute | 24 | 2011-09-29 | 2018-01-09 |
| Cyclophosphamide for Prevention of Graft-Versus-Host Disease After Allogeneic Peripheral Blood Stem Cell Transplantation in Patients With Hematological Malignancies cyclophosphamide, cyclosporine, peripheral blood stem cell transplantation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Fred Hutchinson Cancer Center | 43 | 2011-09-01 | 2017-05-19 |
| Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant supersaturated calcium phosphate rinse, placebo, questionnaire administration - Childhood Acute Lymphoblastic Leukemia in Remission, Childhood Acute Myeloid Leukemia in Remission | Phase 3 | Completed | Children's Oncology Group | 226 | 2011-03-01 | 2019-09-17 |
| Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant infection prophylaxis and management, laboratory biomarker analysis, flow cytometry - Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia | Active not recruiting | City of Hope Medical Center | 153 | 2011-01-11 | 2026-10-22 | |
| Deferasirox in Treating Iron Overload Caused By Blood Transfusions in Patients With Hematologic Malignancies deferasirox, laboratory biomarker analysis, enzyme-linked immunosorbent assay - Acute Undifferentiated Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Wake Forest University Health Sciences | 16 | 2011-01-01 | 2018-09-07 |
| Bendamustine and Idarubicin in Treating Older Patients With Previously Untreated AML or MDS bendamustine hydrochloride, idarubicin - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q) | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 39 | 2010-09-01 | 2017-08-18 |
| Palifermin in Preventing Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer palifermin, flow cytometry, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Completed | Martin, Paul | 6 | 2010-09-01 | 2014-04-02 |
| Clofarabine, Cytarabine, and Filgrastim in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia, Advanced Myelodysplastic Syndrome, and/or Advanced Myeloproliferative Neoplasm filgrastim, clofarabine, cytarabine - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q) | Phase 2 | Completed | University of Washington | 50 | 2010-08-01 | 2017-10-19 |
| Infusion of Off-the-Shelf Expanded Cord Blood Cells to Augment Cord Blood Transplant in Patients With Hematologic Malignancies umbilical cord blood transplantation, fludarabine phosphate, cyclophosphamide - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | Nohla Therapeutics, Inc. | 15 | 2010-08-01 | 2019-03-05 |
| Differentiation Therapy With Decitabine in Treating Patients With Myelodysplastic Syndrome flow cytometry, DNA methylation analysis, cytogenetic analysis - Chronic Myelomonocytic Leukemia, de Novo Myelodysplastic Syndromes | Phase 1 / Phase 2 | Completed | Case Comprehensive Cancer Center | 25 | 2010-07-01 | 2019-03-04 |
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Congenital Abnormalities (52) · Leukemia, Myeloid, Acute (50) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (42) · Leukemia, Myelomonocytic, Chronic (36) · Burkitt Lymphoma (29) · Leukemia, Lymphocytic, Chronic, B-Cell (29) · Leukemia, Myeloid, Accelerated Phase (29) · Blast Crisis (28) · Lymphoma, B-Cell, Marginal Zone (27) · Lymphoma, Follicular (27) · Lymphoma, Large B-Cell, Diffuse (26) · Lymphoma, Mantle-Cell (26) · Lymphoma, Non-Hodgkin (26) · Lymphoma, T-Cell, Cutaneous (26) · Myeloproliferative Disorders (26)
Hematologic Diseases (66) · Hemic and Lymphatic Diseases (66) · Leukemia (65) · Leukemia, Myeloid (65) · Neoplasms (65) · Neoplasms by Histologic Type (65) · Bone Marrow Diseases (60) · Chronic Disease (55) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (55) · Disease Attributes (55) · Pathologic Processes (55) · Pathological Conditions, Signs and Symptoms (55) · Immune System Diseases (42) · Immunoproliferative Disorders (42) · Leukemia, Lymphoid (42)
fludarabine phosphate (18) · Peripheral Blood Stem Cell Transplantation (15) · Whole-Body Irradiation (15) · Mycophenolic Acid (14) · Cyclophosphamide (13) · Cyclosporine (11) · Tacrolimus (11) · Busulfan (10) · Transplantation (10) · Cytarabine (9) · Methotrexate (8) · merphos (8) · Filgrastim (6) · Flow Cytometry (6) · Granulocyte Colony-Stimulating Factor (6)
National Cancer Institute (NCI) (23) · Fred Hutchinson Cancer Center (21) · Children's Oncology Group (5) · City of Hope Medical Center (4) · Case Comprehensive Cancer Center (3) · Roswell Park Cancer Institute (3) · Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium (1) · Martin, Paul (1) · Nohla Therapeutics, Inc. (1) · Rondeep Brar (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1) · Sumithira Vasu (1) · University of Chicago (1) · University of Medicine and Dentistry of New Jersey (1) · University of Nebraska (1)
United States (69) · Canada (4) · Germany (4) · Italy (4) · Australia (2) · Puerto Rico (1)
David Maloney (3) · Francis Giles (3) · Paul Martin (3) · Bart Scott (2) · Brenda Cooper, MD (2) · Brenda Sandmaier (2) · Colleen Delaney (2) · John Pagel (2) · Mark Juckett (2) · Mark Kirschbaum (2) · Ryotaro Nakamura (2) · Alvaro Moreno Aspitia (1) · Amanda Cashen (1) · Andrew Rezvani (1) · B. Smith (1)
PMID 32499241, PMID 19304957, PMID 19786617, PMID 20056794, PMID 20413658, PMID 20522709, PMID 21149673, PMID 21791475, PMID 22259028, PMID 24474568, PMID 25545153, PMID 25621498, PMID 26764356, PMID 26853648, PMID 28389462, PMID 28817727, PMID 30562587, PMID 31375516, PMID 32628342, PMID 32683127, PMID 33420905, PMID 35445027, PMID 36184192, PMID 36282798, PMID 36815378, PMID 38295280, PMID 42085603
P30CA015704 (11), P01HL036444 (4), U10CA098543 (4), P01CA018029 (3), P01CA078902 (3), U01CA062461 (3), U01CA062505 (3), U01CA070095 (3), N01CM62202 (2), N01CM62203 (2), N01CM62205 (2), P30CA015083 (2), RC2HL101844 (2), U01CA062502 (2), K12CA076930 (1)