10 completed, 3 terminated, 1 unknown. 14 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 14 | Completed 10, Terminated 3, Unknown 1 |
| Phase 2 | 4 | Completed 3, Terminated 1 |
Follow Cutaneous Leishmaniasis: new trials by email Literature Review of Cutaneous Leishmaniasis trials Research Report on Cutaneous Leishmaniasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Miltefosine and GM-CSF in Cutaneous Leishmaniasis Sbv, Miltefosine plus placebo, Miltefosine plus GM-CSF - Cutaneous Leishmaniasis | Phase 3 | Completed | Hospital Universitário Professor Edgard Santos | 300 | 2017-06-30 | 2020-04-07 |
| High Dose Fluconazole in Cutaneous Leishmaniasis in Bahia and Manaus Fluconazole, Meglumine Antimoniate - Cutaneous Leishmaniasis | Phase 3 | Terminated | Hospital Universitário Professor Edgard Santos | 53 | 2014-02-01 | 2015-12-02 |
| Phase 3 Study of Walter Reed (WR) 279,396 and Paromomycin Alone for the Treatment of Cutaneous Leishmaniasis in Panama WR 279,396, Paromomycin - Cutaneous Leishmaniasis | Phase 3 | Completed | U.S. Army Medical Research and Development Command | 399 | 2013-05-01 | 2018-02-14 |
| Antimony Plus Pentoxifylline in Cutaneous Leishmaniasis Pentoxifylline, Placebo - Cutaneous Leishmaniasis | Phase 2 / Phase 3 | Completed | Paulo Roberto Lima Machado | 164 | 2012-03-01 | 2017-01-26 |
| Add-on Study of Pentoxifylline in Cutaneous Leishmaniasis Meglumine antimonate, Placebo, Pentoxifylline - Cutaneous Leishmaniasis | Phase 2 / Phase 3 | Completed | Centro Internacional de Entrenamiento e Investigaciones Médicas | 75 | 2011-11-01 | 2016-08-23 |
| Comparison of Standard and Alternative Antimonial Dosage in Patients With American Cutaneous Leishmaniasis Meglumine antimoniate - Cutaneous Leishmaniasis | Phase 2 / Phase 3 | Completed | Oswaldo Cruz Foundation | 72 | 2008-10-01 | 2018-05-15 |
| Safety and Efficacy of Azithromycin to Treat Cutaneous Leishmaniasis Glucantime®, Zithromax ® - Cutaneous Leishmaniasis | Phase 2 / Phase 3 | Terminated | Ana Rabello | 48 | 2008-06-01 | 2014-10-17 |
| Phase 3 Study to Evaluate WR 279,396 vs. Paromomycin Alone to Treat Cutaneous Leishmaniasis (in Tunisia) WR 279,396 topical cream, Paromomycin Alone topical cream, Vehicle placebo cream - Cutaneous Leishmaniasis | Phase 3 | Completed | U.S. Army Medical Research and Development Command | 375 | 2008-01-01 | 2014-07-14 |
| Oral Miltefosine for the Treatment of Pediatric Cutaneous Leishmaniasis in Colombia Miltefosine, Meglumine antimoniate - Cutaneous Leishmaniasis | Phase 3 | Unknown | Centro Internacional de Entrenamiento e Investigaciones Médicas | 150 | 2007-07-01 | 2010-02-17 |
| Efficacy of Intra-lesional Injections of Glucantime Once a Week or Twice a Week in the Treatment of Anthroponotic Cutaneous Leishmaniasis (ACL) Meglumine antimoniate - Cutaneous Leishmaniasis | Phase 3 | Completed | Tehran University of Medical Sciences | 2007-05-01 | 2020-04-09 | |
| Efficacy and Safety of Miltefosine or Thermotherapy for Cutaneous Leishmaniasis in Colombia. Miltefosine, Thermotherapy, Glucantime® - Cutaneous Leishmaniasis | Phase 3 | Completed | Universidad de Antioquia | 437 | 2006-06-01 | 2019-01-16 |
| Efficacy Trial on Oral Miltefosine in Comparison With Glucantime in the Treatment of ACL Caused by L. Tropica Miltefose - Cutaneous Leishmaniasis | Phase 3 | Completed | Tehran University of Medical Sciences | 148 | 2006-05-01 | 2011-09-20 |
| Controlled Nitric Oxide Releasing Patch Versus Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis controlled nitric oxide releasing patch, meglumine antimoniate - Cutaneous Leishmaniasis | Phase 3 | Terminated | Fundación Cardiovascular de Colombia | 178 | 2006-05-01 | 2010-11-24 |
| Imiquimod Plus Antimony Immunochemotherapy for Cutaneous Leishmaniasis Imiquimod - Cutaneous Leishmaniasis | Phase 3 | Completed | Drugs for Neglected Diseases | 80 | 2005-12-01 | 2008-06-12 |
Leishmaniasis, Cutaneous (14) · Leishmaniasis (3) · Hyperthermia (1)
Euglenozoa Infections (14) · Infections (14) · Parasitic Diseases (14) · Protozoan Infections (14) · Skin Diseases (14) · Skin Diseases, Infectious (14) · Skin Diseases, Parasitic (14) · Skin and Connective Tissue Diseases (14) · Vector Borne Diseases (14) · Leishmaniasis (11) · Body Temperature Changes (1) · Heat Stress Disorders (1) · Pathological Conditions, Signs and Symptoms (1) · Signs and Symptoms (1) · Wounds and Injuries (1)
Meglumine Antimoniate (9) · miltefosine (3) · Pentoxifylline (2) · Azithromycin (1) · Contraceptives, Oral (1) · Fluconazole (1) · Granulocyte-Macrophage Colony-Stimulating Factor (1) · Hyperthermia, Induced (1) · Imiquimod (1) · Paromomycin (1)
Centro Internacional de Entrenamiento e Investigaciones Médicas (2) · Hospital Universitário Professor Edgard Santos (2) · Tehran University of Medical Sciences (2) · U.S. Army Medical Research and Development Command (2) · Ana Rabello (1) · Drugs for Neglected Diseases (1) · Fundación Cardiovascular de Colombia (1) · Oswaldo Cruz Foundation (1) · Paulo Roberto Lima Machado (1) · Universidad de Antioquia (1)
Brazil (5) · Colombia (3) · Iran (2) · Panama (1) · Peru (1) · Tunisia (1)
Afif Ben Salah, M.D., Ph.D. (1) · Ali Khamesipour (1) · Ali Khamesipour, PhD (1) · Alireza Khatami, MD MSPH (1) · Ana Rabello, MD PhD (1) · Armando O. Schubach, MD, PhD (1) · Catherine Royce, Dr (1) · Christian F Rueda-Clausen, MD (1) · Daniel J Smith, PhD (1) · Daniel Smith, PhD (1) · Edgar M Carvalho, MD, PhD (1) · Federico A Silva, MD (1) · Gerson Penna, MD, PhD (1) · Hernando Mosquera, MD (1)
PMID 28379954, PMID 19636365, PMID 22238470, PMID 22594858, PMID 23388004, PMID 23740007, PMID 27803094, PMID 28558061, PMID 32894278, PMID 33253864