11 completed. 11 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 11 | Completed 11 |
Follow Cold Exposure: new trials by email Literature Review of Cold Exposure trials Research Report on Cold Exposure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity Caffeine (200 mg), Placebo - Brown Adipose Tissue (BAT) Physiology, Cold Exposure | Not applicable | Completed | University Hospital, Basel, Switzerland | 12 | 2026-01-21 | 2026-07-31 |
| Effect of Pre-cooling on Whole-body Heat Loss During Exercise-heat Stress No Cooling, Pre-Cooling - Thermoregulation, Cold Exposure | Not applicable | Completed | University of Ottawa | 10 | 2024-10-24 | 2025-06-17 |
| Cold Water Exposure's Effects on Physical and Mental Health Cold Water Immersion (CWI) - Cold Tub Immersion (CI), Cold Water Immersion (CWI) - Cold Shower (CS) - Cold Exposure | Not applicable | Completed | University of Northern Colorado | 36 | 2024-10-10 | 2026-09-30 |
| The Influence of Race and MitoQ Supplementation on Skin Blood Flow in the Cold Mitoquinone mesylate (MitoQ), Placebo, Cold Water Hand Immersion - Cold Exposure | Not applicable | Completed | United States Army Research Institute of Environmental Medicine | 26 | 2024-09-16 | 2026-04-30 |
| The Effects of Nitrate, Caffeine, and Cold Exposure on Cardiovascular Function. TruBeet inorganic beetroot juice, Caffeine, Cold pressor test - Nitrate, Caffeine | Not applicable | Completed | Loughborough University | 24 | 2023-12-05 | 2025-09-12 |
| The Effects of Cold Adaptation on Skin Blood Flow, Hand Function, and Comfort in Healthy Adults Repeated cold exposure - Cold Exposure | Not applicable | Completed | United States Army Research Institute of Environmental Medicine | 16 | 2022-08-01 | 2025-12-26 |
| The Effectiveness of the Wim Hof Method Wim Hof Method - Healthy, Blood Pressure | Not applicable | Completed | University of Bern | 42 | 2022-05-01 | 2023-06-08 |
| The Effect of Cold Exposure on Energy Expenditure Cold exposure - Cold Exposure | Not applicable | Completed | Maastricht University | 26 | 2021-05-17 | 2022-07-28 |
| Effects of Calorie Restriction and Cold Stimuli on Health-related Indicators, Cognitive and Motor Functions 2-days of zero calorie restriction and whole-body cold-water immersion, 6-days of calorie restriction, 2-days of zero calorie restriction without whole-body cold-water immersion - Calorie Deficiency, Fasting | Not applicable | Completed | Lithuanian Sports University | 80 | 2021-02-08 | 2024-07-15 |
| Hand Cooling With Ice Packs in Healthy Young Men Ice Pack (Localized Cryotherapy), Thermoneutral Water Pack (Control) - Cold Exposure, Body Temperature Regulation | Not applicable | Completed | Poznan University of Physical Education | 39 | 2018-04-12 | 2025-11-28 |
| Effects of Cold Exposure and Breathing Techniques on Immune Response Cold Exposure, Strength Ventilation - Cold Exposure, Hyperventilation | Not applicable | Completed | Radboud University Medical Center | 48 | 2016-04-12 | 2019-04-01 |
Endotoxemia (1) · Fasting (1) · Heat Stress Disorders (1) · Hyperventilation (1) · Inflammation (1) · Motor Activity (1) · Multiple Endocrine Neoplasia Type 1 (1) · Starvation (1) · Weight Loss (1)
Behavior (2) · Pathological Conditions, Signs and Symptoms (2) · Signs and Symptoms (2) · Bacteremia (1) · Body Weight (1) · Body Weight Changes (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Endocrine Gland Neoplasms (1) · Endocrine System Diseases (1) · Feeding Behavior (1) · Genetic Diseases, Inborn (1) · Infections (1) · Malnutrition (1) · Multiple Endocrine Neoplasia (1) · Neoplasms (1)
Caffeine (2) · mitoquinone (1)
United States Army Research Institute of Environmental Medicine (2) · Lithuanian Sports University (1) · Loughborough University (1) · Maastricht University (1) · Poznan University of Physical Education (1) · Radboud University Medical Center (1) · University Hospital, Basel, Switzerland (1) · University of Bern (1) · University of Northern Colorado (1) · University of Ottawa (1)
United States (3) · Netherlands (2) · Switzerland (2) · Canada (1) · Lithuania (1) · Poland (1) · United Kingdom (1)
Billie K Alba, Ph.D. (1) · Glen P Kenny, PhD (1) · Jelle Zwaag, MSc (1) · Matthias Betz, Prof. (1) · Pawel P Korman, PhD (1) · Sascha Ketelhut, PhD (1) · Stephen Bailey (1) · W. van Marken Lichtenbelt, PhD (1)
PMID 35213875, PMID 38108909, PMID 40067458, PMID 40670486, PMID 41484413, PMID 42323358