12 recruiting, 2 completed, 1 active not recruiting. 8 Phase 2, 1 Early Phase 1, 1 Not applicable, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Recruiting 7, Active not recruiting 1 |
| Early Phase 1 | 1 | Recruiting 1 |
| Not applicable | 1 | Recruiting 1 |
| Phase 1 | 1 | Completed 1 |
Follow Clonal Cytopenia of Undetermined Significance: new trials by email Literature Review of Clonal Cytopenia of Undetermined Significance trials Research Report on Clonal Cytopenia of Undetermined Significance
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Research On Nicotinamide Riboside Supplement Support in MDS (ROSS Trial) Nicotinamide Riboside, Pterostilbene - Clonal Cytopenia of Undetermined Significance, Myelodysplastic Syndrome | Phase 2 | Recruiting | University of Colorado, Denver | 10 | 2026-05-20 | 2026-06-03 |
| Clonal Hematopoiesis Chemotherapy and Radiation Effects Study Samples - Lung Cancer (Diagnosis), Osteochondroma | Recruiting | Dana-Farber Cancer Institute | 5000 | 2025-04-04 | 2026-06-30 | |
| Early Intervention in High Risk CCUS Inqovi - Clonal Cytopenia of Undetermined Significance, Cytopenia | Early Phase 1 | Recruiting | Lachelle D. Weeks, MD, PhD | 108 | 2025-02-07 | 2026-04-23 |
| A Phase 2 Study Evaluating Olutasidenib in Patients With IDH1-mutated Clonal Cytopenia of Undetermined Significance and Lower-risk Myelodysplastic/Syndromes/Chronic Myelomonocytic Leukemia. Olutasidenib - Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 15 | 2024-12-10 | 2026-09-11 |
| Enasidenib for Patients With Clonal Cytopenia of Undetermined Significance and Mutations in IDH2A Decentralized Trial Enasidenib - Clonal Cytopenia of Undetermined Significance, CCUS Clonal Cytopenia of Undetermined Significance | Phase 2 | Recruiting | Washington University School of Medicine | 15 | 2024-10-10 | 2026-08-10 |
| Curcumin to Improve Inflammation and Symptoms in Patients With Clonal Cytopenia of Undetermined Significance, Low Risk Myelodysplastic Syndrome, and Myeloproliferative Neoplasms Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Clonal Cytopenia of Undetermined Significance, Essential Thrombocythemia | Phase 2 | Recruiting | University of Southern California | 30 | 2024-03-01 | 2026-03-27 |
| Statins in Patients With Clonal Cytopenia of Undetermined Significance (CCUS) and Myelodysplastic Syndromes (MDS) Atorvastatin, Rosuvastatin - Clonal Cytopenia of Undetermined Significance, Myelodysplastic Syndromes | Phase 2 | Recruiting | Washington University School of Medicine | 16 | 2024-02-19 | 2026-07-23 |
| Clonal Hematopoiesis and Therapy-Emergent Myeloid Neoplasms in Patients With Cancers, CHANCES Study Non-Interventional Study - Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma | Recruiting | University of Washington | 2000 | 2024-01-02 | 2026-04-17 | |
| Canakinumab for the Prevention of Progression to Cancer in Patients With Clonal Cytopenias of Unknown Significance, IMPACT Study Biospecimen Collection, Bone Marrow Aspiration and Biopsy, Canakinumab - Clonal Cytopenia of Undetermined Significance | Phase 2 | Recruiting | Uma Borate | 110 | 2023-02-06 | 2026-01-02 |
| Ivosidenib for Patients With Clonal Cytopenia of Undetermined Significance and Mutations in IDH1 Ivosidenib - Clonal Cytopenia of Undetermined Significance | Phase 2 | Active not recruiting | Washington University School of Medicine | 20 | 2022-04-01 | 2026-08-12 |
| Acquired Pyruvate Kinase Deficiency In Clonal Myeloid Neoplasms Blood Draw - Pyruvate Kinase Deficiency, Pyruvate Kinase Deficiency Anemia | Completed | Massachusetts General Hospital | 18 | 2022-02-01 | 2026-05-19 | |
| A Study of Enasidenib in People With Clonal Cytopenia of Undetermined Significance Enasidenib - Clonal Cytopenia of Undetermined Significance, CCUS Clonal Cytopenia of Undetermined Significance | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 4 | 2021-10-06 | 2026-01-27 |
| CHIP/CCUS Natural History Protocol Clonal Hematopoiesis of Indeterminate Potential, Clonal Cytopenia of Undetermined Significance | Recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 306 | 2020-03-03 | 2026-09-28 | |
| Ascorbic Acid and Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma, CCUS, and Chronic Myelomonocytic Leukemia Ascorbic Acid, Carboplatin, Cisplatin - Clonal Cytopenia of Undetermined Significance, High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements | Phase 2 | Recruiting | Mayo Clinic | 80 | 2018-03-23 | 2026-09-28 |
| Pre-myeloid Cancer and Bone Marrow Failure Clinic Study Biospecimen Collection, Bone Marrow Biopsy, Punch Biopsy - Myeloid Malignancy, Inherited Bone Marrow Failure Syndrome | Not applicable | Recruiting | Mayo Clinic | 2000 | 2017-01-16 | 2026-02-23 |
Myelodysplastic Syndromes (6) · Cytopenia (3) · Leukemia, Myelomonocytic, Chronic (2) · Adenocarcinoma Of Esophagus (1) · Anemia, Hemolytic, Congenital (1) · Bone Marrow Failure Disorders (1) · Breast Neoplasms (1) · Colonic Neoplasms (1) · Congenital Bone Marrow Failure Syndromes (1) · Disease (1) · Fallopian Tube Neoplasms (1) · Head and Neck Neoplasms (1) · Hematologic Neoplasms (1) · Hodgkin Disease (1) · Inflammation (1)
Hematologic Diseases (9) · Hemic and Lymphatic Diseases (9) · Bone Marrow Diseases (8) · Neoplasms (7) · Neoplasms by Histologic Type (4) · Neoplasms by Site (4) · Pathologic Processes (4) · Pathological Conditions, Signs and Symptoms (4) · Leukemia (3) · Leukemia, Myeloid (3) · Chronic Disease (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Disease Attributes (2) · Genetic Diseases, Inborn (2) · Myelodysplastic-Myeloproliferative Diseases (2)
Biopsy (4) · Specimen Handling (4) · X-Rays (2) · decitabine and cedazuridine drug combination (2) · enasidenib (2) · 1,2-diaminocyclohexaneplatinum II citrate (1) · Ascorbic Acid (1) · Atorvastatin (1) · Biopsy, Large-Core Needle (1) · Biopsy, Needle (1) · Blood Specimen Collection (1) · CT-P10 (1) · Calcium Dobesilate (1) · Carboplatin (1) · Central Venous Catheters (1)
Washington University School of Medicine (3) · Mayo Clinic (2) · Dana-Farber Cancer Institute (1) · Lachelle D. Weeks, MD, PhD (1) · M.D. Anderson Cancer Center (1) · Massachusetts General Hospital (1) · Memorial Sloan Kettering Cancer Center (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · Uma Borate (1) · University of Colorado, Denver (1) · University of Southern California (1) · University of Washington (1)
United States (15)
Amber Afzal, M.D., MSCI (1) · Casey L O'Connell, MD (1) · Elizabeth Swisher (1) · Eytan Stein, MD (1) · Fernanda Gutierrez Rodrigues (1) · Giulia Petrone, M.D. (1) · Hanny Al-Samkari, MD (1) · Kelly Bolton, M.D., Ph.D. (1) · Kelly Chien, MD (1) · Lachelle D Weeks, MD, PhD (1) · Lachelle Weeks, MD (1) · Maria Amaya, PhD MD (1) · Mrinal S. Patnaik, MBBS (1) · Thomas E Witzig, M.D. (1) · Uma M Borate, MD, MS (1)
P30CA014089 (1), P50CA097274 (1), R01CA272594 (1)