17 completed, 2 active not recruiting, 1 recruiting, 1 terminated. 7 Phase 2, 6 Not applicable, 6 Phase 1, 2 Phase 3, 1 Early Phase 1.
Follow Chronic Neutrophilic Leukemia: new trials by email Literature Review of Chronic Neutrophilic Leukemia trials Research Report on Chronic Neutrophilic Leukemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Momelotinib in Combination With Hypomethylating Agent for Chronic Phase Myelodysplastic Syndromes/Myeloproliferative Overlap Neoplasms and Chronic Neutrophilic Leukemia Momelotinib, Azacitidine - Chronic Myelomonocytic Leukemia, Myelodysplastic Syndromes | Early Phase 1 | Recruiting | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 18 | 2026-03-19 | 2026-03-27 |
| Fedratinib in Myelodysplastic /Myeloproliferative Neoplasms (MDS/MPNs) and Chronic Neutrophilic Leukemia (CNL) Fedratinib Pill - Myeloproliferative Neoplasm, Chronic Neutrophilic Leukemia | Phase 2 | Completed | H. Lee Moffitt Cancer Center and Research Institute | 25 | 2022-03-01 | 2026-06-09 |
| Azacitidine, Venetoclax, and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Azacitidine, Pevonedistat, Venetoclax - Acute Myeloid Leukemia, Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative | Phase 1 / Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 40 | 2019-02-27 | 2026-07-16 |
| Ruxolitinib Phosphate in Treating Patients With Chronic Neutrophilic Leukemia or Atypical Chronic Myeloid Leukemia Laboratory Biomarker Analysis, Quality-of-Life Assessment, Questionnaire Administration - Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative, Chronic Neutrophilic Leukemia | Phase 2 | Completed | OHSU Knight Cancer Institute | 51 | 2014-07-08 | 2020-11-16 |
| Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem Cell Transplant management of therapy complications, musculoskeletal complications management/prevention - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Withdrawn | Roswell Park Cancer Institute | 2012-05-01 | 2012-07-09 | |
| A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies Fludarabine, Busulfan, Total Body Irradiation (TBI) - Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 40 | 2011-08-04 | 2026-04-15 |
| Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant supersaturated calcium phosphate rinse, placebo, questionnaire administration - Childhood Acute Lymphoblastic Leukemia in Remission, Childhood Acute Myeloid Leukemia in Remission | Phase 3 | Completed | Children's Oncology Group | 226 | 2011-03-01 | 2019-09-17 |
| Prolonged or Standard Infusion of Cefepime Hydrochloride in Treating Patients With Febrile Neutropenia cefepime hydrochloride - Adult Acute Lymphoblastic Leukemia, Adult Acute Myeloid Leukemia | Phase 1 | Completed | Wake Forest University Health Sciences | 70 | 2011-02-01 | 2018-07-18 |
| Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant infection prophylaxis and management, laboratory biomarker analysis, flow cytometry - Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia | Active not recruiting | City of Hope Medical Center | 153 | 2011-01-11 | 2026-10-22 | |
| MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Leukemia Akt inhibitor MK2206, diagnostic laboratory biomarker analysis, pharmacological study - Accelerated Phase Chronic Myelogenous Leukemia, Acute Leukemias of Ambiguous Lineage | Phase 1 | Completed | National Cancer Institute (NCI) | 45 | 2011-01-01 | 2014-04-29 |
| Palifermin in Preventing Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer palifermin, flow cytometry, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Completed | Martin, Paul | 6 | 2010-09-01 | 2014-04-02 |
| Deferasirox for Treating Patients Who Have Undergone Allogeneic Stem Cell Transplant and Have Iron Overload deferasirox - Iron Overload, Accelerated Phase Chronic Myelogenous Leukemia | Phase 2 | Terminated | City of Hope Medical Center | 1 | 2010-07-01 | 2019-06-18 |
| Massage Therapy Given by Caregiver in Treating Quality of Life of Young Patients Undergoing Treatment for Cancer massage therapy, questionnaire administration, quality-of-life assessment - Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia | Not applicable | Completed | Wake Forest University Health Sciences | 80 | 2010-04-01 | 2018-07-02 |
| Sunitinib Malate in Treating HIV-Positive Patients With Cancer Receiving Antiretroviral Therapy sunitinib malate, pharmacological study, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 1 | Completed | National Cancer Institute (NCI) | 42 | 2009-08-01 | 2014-03-17 |
| Fludarabine Phosphate, Melphalan, Total-Body Irradiation, Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer or Bone Marrow Failure Disorders fludarabine phosphate, melphalan, total-body irradiation - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Not applicable | Completed | Roswell Park Cancer Institute | 62 | 2009-01-14 | 2019-11-13 |
| Ondansetron in Preventing Nausea and Vomiting in Patients Undergoing Stem Cell Transplant ondansetron, survey administration, management of therapy complications - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Fred Hutchinson Cancer Center | 49 | 2008-08-08 | 2017-05-23 |
| Internet-Based Program With or Without Telephone-Based Problem-Solving Training in Helping Long-Term Survivors of Hematopoietic Stem Cell Transplant Cope With Late Complications internet-based intervention, questionnaire administration, psychosocial assessment and care - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 3 | Completed | Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium | 1337 | 2008-08-01 | 2012-03-07 |
| Beclomethasone Dipropionate in Preventing Acute Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant for Hematologic Cancer beclomethasone dipropionate, placebo, tacrolimus - Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 140 | 2007-04-01 | 2021-02-03 |
| Lithium Carbonate in Treating Patients With Acute Intestinal Graft-Versus-Host-Disease (GVHD) After Donor Stem Cell Transplant lithium carbonate, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Completed | Fred Hutchinson Cancer Center | 20 | 2006-06-01 | 2017-03-07 |
| Vorinostat, Cytarabine, and Etoposide in Treating Patients With Relapsed and/or Refractory Acute Leukemia or Myelodysplastic Syndromes or Myeloproliferative Disorders vorinostat, cytarabine, etoposide - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Basophilic Leukemia | Phase 1 | Completed | National Cancer Institute (NCI) | 25 | 2006-05-01 | 2013-05-03 |
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Leukemia, Neutrophilic, Chronic (22) · Leukemia, Myelomonocytic, Chronic (20) · Pdgfra-Associated Chronic Eosinophilic Leukemia (18) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (18) · Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative (17) · Myeloproliferative Disorders (17) · Primary Myelofibrosis (17) · Burkitt Lymphoma (16) · Leukemia, Lymphocytic, Chronic, B-Cell (16) · Leukemia, Myeloid, Acute (16) · Leukemia, Myeloid, Accelerated Phase (15) · Lymphoma, B-Cell, Marginal Zone (15) · Lymphoma, Follicular (15) · Lymphoma, Large B-Cell, Diffuse (15) · Lymphoma, T-Cell, Cutaneous (15)
Bone Marrow Diseases (22) · Chronic Disease (22) · Disease Attributes (22) · Hematologic Diseases (22) · Hemic and Lymphatic Diseases (22) · Pathologic Processes (22) · Pathological Conditions, Signs and Symptoms (22) · Leukemia, Myeloid (21) · Neoplasms (21) · Neoplasms by Histologic Type (21) · Leukemia (20) · Myelodysplastic-Myeloproliferative Diseases (20) · Immune System Diseases (18) · Immunoproliferative Disorders (18) · Leukemia, Lymphoid (18)
Therapeutics (3) · Whole-Body Irradiation (3) · fludarabine phosphate (3) · Azacitidine (2) · Flow Cytometry (2) · Mycophenolic Acid (2) · Peripheral Blood Stem Cell Transplantation (2) · Tacrolimus (2) · Antilymphocyte Serum (1) · Antiviral Agents (1) · Beclomethasone (1) · Busulfan (1) · Cefepime (1) · Counseling (1) · Cyclophosphamide (1)
Fred Hutchinson Cancer Center (4) · National Cancer Institute (NCI) (4) · City of Hope Medical Center (2) · Roswell Park Cancer Institute (2) · Wake Forest University Health Sciences (2) · Children's Oncology Group (1) · Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium (1) · H. Lee Moffitt Cancer Center and Research Institute (1) · M.D. Anderson Cancer Center (1) · Martin, Paul (1) · OHSU Knight Cancer Institute (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1)
United States (21) · Canada (2) · Australia (1)
Paul Martin (3) · Andrew Kuykendall, MD (1) · Ann Woolfrey (1) · Douglas Ross (1) · George Chen (1) · Janet Tooze, PhD (1) · John Deeken (1) · John Williamson (1) · Karen Syrjala (1) · Kim-Hien Dao (1) · Leona Holmberg (1) · Maryam Fouladi (1) · Nathaniel Treister, MD (1) · Nicholas Short (1) · Philip McCarthy (1)
PMID 18698002, PMID 22259028, PMID 24474568, PMID 25180155, PMID 28817727, PMID 31880950, PMID 32628342, PMID 33420905, PMID 36282798, PMID 37422688
P01CA018029 (1), P30CA015704 (1), R01CA112631 (1), U01CA062487 (1), U01CA062491 (1), U01CA062502 (1), U01CA062505 (1), U01CA097452 (1), U01CA099168 (1), U01CA121947 (1), U10CA095861 (1)