70 completed, 23 terminated, 9 withdrawn, 4 active not recruiting. 35 Phase 2, 28 Phase 1, 27 Not applicable, 13 Phase 3, 2 Early Phase 1.
Follow Leukemia, Neutrophilic, Chronic: new trials by email Literature Review of Leukemia, Neutrophilic, Chronic trials Research Report on Leukemia, Neutrophilic, Chronic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Momelotinib in Combination With Hypomethylating Agent for Chronic Phase Myelodysplastic Syndromes/Myeloproliferative Overlap Neoplasms and Chronic Neutrophilic Leukemia Momelotinib, Azacitidine - Chronic Myelomonocytic Leukemia, Myelodysplastic Syndromes | Early Phase 1 | Recruiting | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 18 | 2026-03-19 | 2026-03-27 |
| Fedratinib in Myelodysplastic /Myeloproliferative Neoplasms (MDS/MPNs) and Chronic Neutrophilic Leukemia (CNL) Fedratinib Pill - Myeloproliferative Neoplasm, Chronic Neutrophilic Leukemia | Phase 2 | Completed | H. Lee Moffitt Cancer Center and Research Institute | 25 | 2022-03-01 | 2026-06-09 |
| A Study of TAS1553 in Subjects With Relapsed or Refractory Acute Myeloid Leukemia (AML) and Other Myeloid Neoplasms TAS1553 - Acute Myeloid Leukemia, Myeloproliferative Neoplasm | Phase 1 | Terminated | Astex Pharmaceuticals, Inc. | 20 | 2020-12-21 | 2024-08-02 |
| Azacitidine, Venetoclax, and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Azacitidine, Pevonedistat, Venetoclax - Acute Myeloid Leukemia, Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative | Phase 1 / Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 40 | 2019-02-27 | 2026-07-16 |
| Ruxolitinib Phosphate in Treating Patients With Chronic Neutrophilic Leukemia or Atypical Chronic Myeloid Leukemia Laboratory Biomarker Analysis, Quality-of-Life Assessment, Questionnaire Administration - Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative, Chronic Neutrophilic Leukemia | Phase 2 | Completed | OHSU Knight Cancer Institute | 51 | 2014-07-08 | 2020-11-16 |
| Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem Cell Transplant management of therapy complications, musculoskeletal complications management/prevention - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Withdrawn | Roswell Park Cancer Institute | 2012-05-01 | 2012-07-09 | |
| A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies Fludarabine, Busulfan, Total Body Irradiation (TBI) - Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 40 | 2011-08-04 | 2026-04-15 |
| Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant supersaturated calcium phosphate rinse, placebo, questionnaire administration - Childhood Acute Lymphoblastic Leukemia in Remission, Childhood Acute Myeloid Leukemia in Remission | Phase 3 | Completed | Children's Oncology Group | 226 | 2011-03-01 | 2019-09-17 |
| Prolonged or Standard Infusion of Cefepime Hydrochloride in Treating Patients With Febrile Neutropenia cefepime hydrochloride - Adult Acute Lymphoblastic Leukemia, Adult Acute Myeloid Leukemia | Phase 1 | Completed | Wake Forest University Health Sciences | 70 | 2011-02-01 | 2018-07-18 |
| Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant infection prophylaxis and management, laboratory biomarker analysis, flow cytometry - Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia | Active not recruiting | City of Hope Medical Center | 153 | 2011-01-11 | 2026-10-22 | |
| MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Leukemia Akt inhibitor MK2206, diagnostic laboratory biomarker analysis, pharmacological study - Accelerated Phase Chronic Myelogenous Leukemia, Acute Leukemias of Ambiguous Lineage | Phase 1 | Completed | National Cancer Institute (NCI) | 45 | 2011-01-01 | 2014-04-29 |
| Palifermin in Preventing Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer palifermin, flow cytometry, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Completed | Martin, Paul | 6 | 2010-09-01 | 2014-04-02 |
| Sirolimus, Tacrolimus, Thymoglobulin and Rituximab as Graft-versus-Host-Disease Prophylaxis in Patients Undergoing Haploidentical and HLA Partially Matched Donor Hematopoietic Cell Transplantation anti-thymocyte globulin, rituximab, sirolimus - Chronic Myeloproliferative Disorders, Graft Versus Host Disease | Phase 2 | Terminated | Barbara Ann Karmanos Cancer Institute | 4 | 2010-08-01 | 2019-03-26 |
| Deferasirox for Treating Patients Who Have Undergone Allogeneic Stem Cell Transplant and Have Iron Overload deferasirox - Iron Overload, Accelerated Phase Chronic Myelogenous Leukemia | Phase 2 | Terminated | City of Hope Medical Center | 1 | 2010-07-01 | 2019-06-18 |
| Massage Therapy Given by Caregiver in Treating Quality of Life of Young Patients Undergoing Treatment for Cancer massage therapy, questionnaire administration, quality-of-life assessment - Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia | Not applicable | Completed | Wake Forest University Health Sciences | 80 | 2010-04-01 | 2018-07-02 |
| Lactobacillus in Preventing Infection in Patients Undergoing a Donor Stem Cell Transplant for Hematologic Cancer or Myelodysplastic Syndrome Lactobacillus rhamnosus GG - Breast Cancer, Chronic Myeloproliferative Disorders | Not applicable | Terminated | Rutgers, The State University of New Jersey | 30 | 2010-03-01 | 2017-02-03 |
| Presence of Donor-Derived DNA in Semen Samples From Cancer Survivors Who Underwent Donor Stem Cell Transplant DNA analysis, polymerase chain reaction, flow cytometry - Cancer Survivor, Chronic Myeloproliferative Disorders | Terminated | Vanderbilt University | 24 | 2010-02-01 | 2014-12-10 | |
| Registry of Older Patients With Cancer Chronic Myeloproliferative Disorders, Cognitive/Functional Effects | Recruiting | UNC Lineberger Comprehensive Cancer Center | 3000 | 2009-09-01 | 2026-06-29 | |
| 3'-Deoxy-3'-[18F] Fluorothymidine PET Imaging in Patients With Cancer 3'-deoxy-3'-[18F]fluorothymidine - Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders | Active not recruiting | Barbara Ann Karmanos Cancer Institute | 2009-09-01 | 2026-08-10 | ||
| Sunitinib Malate in Treating HIV-Positive Patients With Cancer Receiving Antiretroviral Therapy sunitinib malate, pharmacological study, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 1 | Completed | National Cancer Institute (NCI) | 42 | 2009-08-01 | 2014-03-17 |
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Pdgfra-Associated Chronic Eosinophilic Leukemia (107) · Myeloproliferative Disorders (104) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (104) · Primary Myelofibrosis (104) · Leukemia, Lymphocytic, Chronic, B-Cell (100) · Leukemia, Myeloid, Acute (99) · Leukemia, Myelomonocytic, Chronic (99) · Lymphoma, Follicular (97) · Burkitt Lymphoma (96) · Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative (96) · Lymphoma, Large B-Cell, Diffuse (96) · Lymphoma, Mantle-Cell (96) · Leukemia, Myeloid, Accelerated Phase (94) · Lymphoma, Large-Cell, Immunoblastic (94)
Bone Marrow Diseases (112) · Chronic Disease (112) · Disease Attributes (112) · Hematologic Diseases (112) · Hemic and Lymphatic Diseases (112) · Pathologic Processes (112) · Pathological Conditions, Signs and Symptoms (112) · Leukemia, Myeloid (111) · Neoplasms by Histologic Type (111) · Immune System Diseases (106) · Immunoproliferative Disorders (104) · Leukemia, Lymphoid (104) · Lymphatic Diseases (104) · Hemorrhagic Disorders (103) · Leukemia, B-Cell (100)
Cyclophosphamide (18) · fludarabine phosphate (18) · Busulfan (17) · Peripheral Blood Stem Cell Transplantation (16) · Methotrexate (14) · Tacrolimus (14) · Antilymphocyte Serum (13) · Mycophenolic Acid (12) · Cyclosporine (11) · Flow Cytometry (9) · Whole-Body Irradiation (8) · Filgrastim (7) · Cord Blood Stem Cell Transplantation (6) · Etoposide (6) · Melphalan (6)
Fred Hutchinson Cancer Center (15) · City of Hope Medical Center (8) · National Cancer Institute (NCI) (7) · OHSU Knight Cancer Institute (7) · Vanderbilt-Ingram Cancer Center (6) · Case Comprehensive Cancer Center (5) · Barbara Ann Karmanos Cancer Institute (4) · European Organisation for Research and Treatment of Cancer - EORTC (4) · M.D. Anderson Cancer Center (4) · Masonic Cancer Center, University of Minnesota (4) · H. Lee Moffitt Cancer Center and Research Institute (3) · Roswell Park Cancer Institute (3) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (3) · UNC Lineberger Comprehensive Cancer Center (3) · Wake Forest University Health Sciences (3)
United States (92) · Canada (5) · France (5) · Belgium (4) · Germany (4) · Italy (4) · Slovakia (3) · Switzerland (3) · Turkey (Türkiye) (3) · Israel (2) · South Korea (2) · Australia (1) · Czechia (1) · Greece (1) · Hungary (1)
Paul Martin (3) · John E. Wagner, MD (2) · Jorge Cortes, MD (2) · Joseph Bubalo, PharmD, BCPS, BCOP (2) · Kenneth G. Lucas, MD (2) · Kyoo H. Lee, MD (2) · Madan Jagasia, MD (2) · Richard Maziarz, MD (2) · Roger Strair, MD, PhD (2) · Teresa Field, MD, PhD (2) · Adam J. Esbenshade, MD (1) · Alex Shalaurov, MD, PhD (1) · Andrew Kuykendall, MD (1) · Ann E. Woolfrey, MD (1) · Ann Mohrbacher, MD (1)
PMID 15466923, PMID 15570084, PMID 17397698, PMID 18698002, PMID 19139736, PMID 19270260, PMID 19841031, PMID 20124511, PMID 21719601, PMID 22157574, PMID 22259028, PMID 22480131, PMID 23358983, PMID 24474568, PMID 25180155, PMID 26175532, PMID 26210442, PMID 26700120, PMID 26700123, PMID 27020837, PMID 28817727, PMID 30205939, PMID 31880950, PMID 32628342, PMID 33420905, PMID 36282798, PMID 37422688
P30CA033572 (7), P30CA068485 (7), P30CA022453 (4), P30CA072720 (4), P30CA016086 (3), P30CA043703 (3), P30CA006973 (2), P30CA016058 (2), P30CA069533 (2), P01CA015396 (1), P01CA018029 (1), P30CA014520 (1), P30CA015083 (1), P30CA015704 (1), P30CA016672 (1)