91 completed, 32 recruiting, 26 terminated, 9 active not recruiting. 52 Phase 1, 46 Phase 2, 42 Not applicable, 8 Phase 3, 7 Early Phase 1.
Follow Brain Cancer: new trials by email Literature Review of Brain Cancer trials Research Report on Brain Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study Using Brain Stimulation and Behavioral Therapy to Increase Extent of Resection in Low-Grade Gliomas RNS System Implantation - Glioma, Glioma Intracranial | Not applicable | Not yet recruiting | Medical College of Wisconsin | 3 | 2028-08-01 | 2026-10-13 |
| DEXmedetomidine for Postoperative Analgesia and Delirium Prevention After NEUROsurgery (DEX-NEURO Trial) Dexmedetomidine, Normal Saline (0.9% NaCl) - Neurosurgery, Brain Cancer | Not applicable | Not yet recruiting | University of Malaya | 60 | 2027-01-01 | 2026-11-05 |
| PilotStudyAssessSafeActiveSurveillancApproachLocalThe Pa w/BrainMetsUndergoinCNSPenetratSystemicThe Brain Cancer, Brain Cancer Metastatic | Recruiting | University of California, Irvine | 12 | 2026-08-04 | 2026-09-18 | |
| Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma LMP744, Conventional Surgery or Biopsy - Recurrent Glioblastoma, Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype | Phase 1 / Phase 2 | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 40 | 2026-07-15 | 2026-10-16 |
| Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical Procedures Panitumumab-IRDye800 - Meningioma, Glioblastoma | Early Phase 1 | Recruiting | Eben Rosenthal | 30 | 2026-07-07 | 2026-10-16 |
| Living Well With Brain Cancer: A Group-Based Intervention to Promote Whole-Person Well-Being Group Self-Management Sessions, Educational Materials Only - Brain Cancer | Not applicable | Recruiting | University of Colorado, Denver | 64 | 2026-06-10 | 2026-11-03 |
| Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII silevertinib in combination with temozolomide, temozolomide (TMZ) - Glioblastoma (GBM), Newly Diagnosed Glioblastoma | Phase 2 | Recruiting | Black Diamond Therapeutics, Inc. | 162 | 2026-05-05 | 2026-11-12 |
| Precision Radiotherapy Enabled by Molecular MRI Amide proton transfer radiotherapy, Standard radiotherapy - Brain Cancer | Not applicable | Recruiting | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 20 | 2026-04-29 | 2026-05-06 |
| Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG) Nivolumab, Nivolumab-IRDye800 - Brain Cancer, HGG | Early Phase 1 | Recruiting | Eben Rosenthal | 38 | 2026-03-27 | 2026-07-01 |
| Observational Study of Responses to Treatments in Advanced Central Nervous System (CNS) Tumors SmartMatch testing - Recurrent CNS Tumors, Brain Cancer | Completed | National Cancer Institute (NCI) | 4 | 2026-02-04 | 2026-09-29 | |
| Measuring the Feasibility and Effect of a Virtual Reality Cognitive Training Intervention for Brain Cancer Survivors. Virtual Reality System, Word Search Puzzles - Brain Cancer | Not applicable | Not yet recruiting | University of Cincinnati | 40 | 2026-01-01 | 2026-01-02 |
| Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma Ruxolitinib, Temozolomide, Radiation Therapy - Glioblastoma, Brain Cancer | Phase 2 | Recruiting | Baptist Health South Florida | 190 | 2025-12-03 | 2026-10-02 |
| HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer) HOBSCOTCH-CA - Brain Cancer, Brain Tumor | Not applicable | Recruiting | Dartmouth-Hitchcock Medical Center | 125 | 2025-11-03 | 2025-11-21 |
| Head Stabilization in Whole Brain RT Freedom Pursuit Robotic Platform - Brain Cancer | Not applicable | Withdrawn | Abramson Cancer Center at Penn Medicine | 2025-10-14 | 2025-11-25 | |
| Head-to-Head Evaluation of the Cancer Ontology Supervised Multimodal Orchestration (COSMO) AI System Versus Pathologist-Only Review Digital Pathology Evaluation - Brain Cancer, Lung Cancer (Diagnosis) | Enrolling by invitation | Harvard Medical School (HMS and HSDM) | 30 | 2025-06-12 | 2025-12-29 | |
| Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial Riluzole, Placebo - Breast Cancer, Sarcoma | Phase 2 | Recruiting | University of California, Irvine | 75 | 2024-12-02 | 2026-07-14 |
| TIL Therapy Combined With Pembrolizumab for Advanced Brain Cancer Including Gliomas and Meningiomas Tumor Infiltrating Lymphocytes (TIL), Cyclophosphamide, Fludarabine - Brain Tumor, Brain Metastases | Phase 1 / Phase 2 | Recruiting | Essen Biotech | 85 | 2024-10-20 | 2024-11-05 |
| Enhanced Assistance During Radiotherapy for Unmet Essential Needs Standard assistance, Enhanced assistance - Bone Cancer, Brain Cancer | Not applicable | Completed | Washington University School of Medicine | 33 | 2024-10-04 | 2025-08-26 |
| Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent RVP-001 - Central Nervous System (CNS) Lesions, Brain Metastases | Phase 2 | Completed | Reveal Pharmaceuticals Inc. | 18 | 2024-08-15 | 2025-12-26 |
| 18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery 18F fluciclovine - Brain Metastases, Brain Metastases, Adult | Phase 1 | Recruiting | Baptist Health South Florida | 46 | 2024-04-11 | 2026-05-20 |
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Brain Neoplasms (179) · Glioblastoma (53) · Glioma (46) · Breast Neoplasms (23) · Lung Neoplasms (23) · Neoplasms (23) · Head and Neck Neoplasms (19) · Astrocytoma (16) · Central Nervous System Neoplasms (16) · Prostatic Neoplasms (14) · Meningioma (12) · Oligodendroglioma (12) · Kidney Neoplasms (11) · Pancreatic Neoplasms (9) · Colorectal Neoplasms (8)
Neoplasms by Site (179) · Nervous System Neoplasms (178) · Central Nervous System Diseases (177) · Nervous System Diseases (177) · Brain Diseases (176) · Central Nervous System Neoplasms (163) · Neoplasms (156) · Neoplasms by Histologic Type (92) · Neoplasms, Nerve Tissue (83) · Neoplasms, Germ Cell and Embryonal (80) · Neuroectodermal Tumors (80) · Neoplasms, Glandular and Epithelial (77) · Neoplasms, Neuroepithelial (73) · Astrocytoma (39) · Glioma (29)
Temozolomide (13) · Radiotherapy (8) · Bevacizumab (7) · Surveys and Questionnaires (7) · Cyclophosphamide (5) · Radiosurgery (5) · Dianhydrogalactitol (4) · Magnetic Resonance Spectroscopy (4) · Radiation (4) · pembrolizumab (4) · Aminolevulinic Acid (3) · Erlotinib Hydrochloride (3) · Nivolumab (3) · fluciclovine F-18 (3) · Afatinib (2)
Memorial Sloan Kettering Cancer Center (21) · M.D. Anderson Cancer Center (15) · National Cancer Institute (NCI) (12) · Northwell Health (8) · Baptist Health South Florida (5) · Stanford University (5) · Duke University (3) · Kintara Therapeutics, Inc. (3) · Washington University School of Medicine (3) · Assistance Publique - Hôpitaux de Paris (2) · DNAtrix, Inc. (2) · Dana-Farber Cancer Institute (2) · Dartmouth-Hitchcock Medical Center (2) · Eben Rosenthal (2) · H. Lee Moffitt Cancer Center and Research Institute (2)
United States (143) · Canada (10) · France (8) · United Kingdom (7) · China (6) · Australia (4) · Germany (4) · Italy (4) · Netherlands (4) · Belgium (3) · Denmark (3) · Israel (2) · Spain (2) · Austria (1) · Brazil (1)
John Boockvar, MD (7) · Robert Young, MD (4) · Thomas Kaley, MD (3) · Giles W. Robinson, MD (2) · John DeGroot, MD (2) · Katherine E Warren, M.D. (2) · Nelson Moss, MD (2) · Nicholas Butowski, M.D. (2) · Ronald Blasberg, MD (2) · Santosh Kesari, MD, PhD (2) · Aaron Simon, MD (1) · Abi Vainstein-Haras, MD (1) · Adam Dicker, MD, PhD (1) · Alejandro Berlin, <D (1)
PMID 23545055, PMID 16648043, PMID 19167838, PMID 19801201, PMID 22109661, PMID 22780919, PMID 23341526, PMID 23560574, PMID 26428319, PMID 26939629, PMID 28686124, PMID 28870792, PMID 29432077, PMID 29843811, PMID 29914796, PMID 29948397, PMID 30579270, PMID 31676314, PMID 32078016, PMID 32270710, PMID 32373649, PMID 32477016, PMID 32691060, PMID 32977309, PMID 33014774, PMID 33865382, PMID 34081125, PMID 34214495, PMID 34290067, PMID 34670228, PMID 34981300, PMID 35022322, PMID 35191738, PMID 35419607, PMID 35507403, PMID 35569489, PMID 36394838, PMID 36617554, PMID 36705597, PMID 37188783, PMID 37853118, PMID 38311852, PMID 38537315, PMID 38664311, PMID 38796495, PMID 38853689, PMID 39142829, PMID 39737895, PMID 39969230, PMID 40110060
2015 (2), 1RC2CA148491-01 (1), 2017 (1), P50CA221747 (1), P50NS020023 (1), R01CA176659 (1), R01CA187202 (1), R01CA212638 (1), R01CA236034 (1), R01NS052274 (1), R03CA201684 (1), R21CA137896 (1), R21CA186169 (1), R44CA261240 (1)