3 completed, 2 active not recruiting, 2 terminated, 1 withdrawn. 8 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Completed 3, Active not recruiting 2, Terminated 2, Withdrawn 1 |
Follow ATM Gene Mutation: new trials by email Literature Review of ATM Gene Mutation trials Research Report on ATM Gene Mutation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Low Dose TamOxifen and LifestylE Changes for bReast cANcer prevenTion Tamoxifen 10 mg Tablet, Intermittent caloric restriction, Step counter Device - BRCA Mutation, PALB2 Gene Mutation | Phase 2 | Completed | European Institute of Oncology | 110 | 2024-06-21 | 2026-09-11 |
| Niraparib Before Surgery in Treating Patients With High Risk Localized Prostate Cancer and DNA Damage Response Defects Niraparib, Niraparib Tosylate Monohydrate, Radical Prostatectomy - ATM Gene Mutation, BRCA1 Gene Mutation | Phase 2 | Terminated | University of California, Davis | 11 | 2020-02-25 | 2026-05-14 |
| Epacadostat and Pembrolizumab in Treating Participants With Advanced Pancreatic Cancer Epacadostat, Pembrolizumab - ATM Gene Mutation, Deleterious BRCA1 Gene Mutation | Phase 2 | Withdrawn | M.D. Anderson Cancer Center | 2019-07-31 | 2019-05-30 | |
| Effects of Vitamin B3 in Patients With Ataxia Telangiectasia Vitamin B3 - Ataxia Telangiectasia, ATM Gene Mutation | Phase 2 | Completed | Radboud University Medical Center | 24 | 2019-03-18 | 2022-07-25 |
| Docetaxel, Carboplatin, and Rucaparib Camsylate in Treating Patients With Metastatic Castration Resistant Prostate Cancer With Homologous Recombination DNA Repair Deficiency Carboplatin, Docetaxel, Laboratory Biomarker Analysis - ATM Gene Mutation, BRCA1 Gene Mutation | Phase 2 | Terminated | University of Washington | 18 | 2018-08-24 | 2026-08-26 |
| Olaparib In Metastatic Breast Cancer Olaparib - Metastatic Breast Cancer, Invasive Breast Cancer | Phase 2 | Active not recruiting | Beth Israel Deaconess Medical Center | 114 | 2018-04-01 | 2026-01-05 |
| Lung-MAP: Talazoparib in Treating Patients With HRRD Positive Recurrent Stage IV Squamous Cell Lung Cancer Laboratory Biomarker Analysis, Pharmacological Study, Talazoparib - ATM Gene Mutation, ATR Gene Mutation | Phase 2 | Completed | SWOG Cancer Research Network | 51 | 2017-03-03 | 2021-06-23 |
| Talazoparib in Treating Patients With Recurrent, Refractory, Advanced, or Metastatic Cancers and Alterations in the BRCA Genes Laboratory Biomarker Analysis, Pharmacological Study, Talazoparib - Advanced Malignant Neoplasm, ATM Gene Mutation | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 150 | 2014-12-22 | 2026-06-12 |
Ataxia Telangiectasia (1) · Breast Carcinoma In Situ (1) · Breast Neoplasms (1) · Carcinoma, Intraductal, Noninfiltrating (1) · Fanconi Anemia, Complementation Group D1 (1) · Hereditary Sensory and Autonomic Neuropathies (1) · Neoplasm Metastasis (1) · Neoplasms (1) · Pancreatic Neoplasms (1) · Prostatic Neoplasms (1) · Recurrence (1)
Neoplasms (4) · Neoplasms by Site (4) · Breast Diseases (2) · Skin Diseases (2) · Skin and Connective Tissue Diseases (2) · Adenocarcinoma (1) · Ataxia (1) · Brain Diseases (1) · Breast Neoplasms (1) · Carcinoma (1) · Carcinoma in Situ (1) · Cardiovascular Diseases (1) · Central Nervous System Diseases (1) · Cerebellar Ataxia (1) · Cerebellar Diseases (1)
talazoparib (2) · Carboplatin (1) · Docetaxel (1) · Niacinamide (1) · Tablets (1) · Tamoxifen (1) · epacadostat (1) · nicotinamide-beta-riboside (1) · niraparib (1) · olaparib (1) · pembrolizumab (1) · rucaparib (1)
M.D. Anderson Cancer Center (2) · Beth Israel Deaconess Medical Center (1) · European Institute of Oncology (1) · Radboud University Medical Center (1) · SWOG Cancer Research Network (1) · University of California, Davis (1) · University of Washington (1)
United States (5) · Canada (1) · Italy (1) · Netherlands (1)
Bernardo Bonanni, MD (1) · Heather H. Cheng (1) · Marc Dall'Era (1) · Michel Willemsen, Prof. (1) · Milind Javle (1) · Nadine Tung, MD (1) · Sarina A Piha-Paul (1) · Vassiliki Papadimitrakopoulou (1)
PMID 33119476, PMID 36710203, PMID 39226292, PMID 41604601
2023 (1), P30CA016672 (1), P30CA093373 (1), U10CA180888 (1)