38 completed. 38 Phase 2, 7 Phase 1, 4 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 38 | Completed 38 |
| Phase 1 | 7 | Completed 7 |
| Phase 3 | 4 | Completed 4 |
Follow Aplastic Anemia: new trials by email Literature Review of Aplastic Anemia trials Research Report on Aplastic Anemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety in Transfusion Independent Non-severe Aplastic Anemia Luspatercept, Cyclosporine - Aplastic Anemia | Phase 2 | Completed | Bing Han | 58 | 2022-12-19 | 2025-09-16 |
| Efficacy and Safety of Eltrombopag + Tacrolimus in Chinese Refractory or Relapsed Aplastic Anemia Patients Tacrolimus, Placebo (for Tacrolimus) - Aplastic Anemia, Drug Effect | Phase 2 | Completed | Peking Union Medical College Hospital | 114 | 2020-07-01 | 2023-01-19 |
| Study Assessed the Safety and Efficacy of Eltrombopag in Chinese Refractory or Relapsed Severe Aplastic Anemia (SAA) Subjects. Eltrombopag - Aplastic Anemia | Phase 2 | Completed | Novartis Pharmaceuticals | 20 | 2019-12-09 | 2025-12-30 |
| Study of AMG531 (Romiplostim) in Patients With Aplastic Anemia Romiplostim - Aplastic Anemia | Phase 2 / Phase 3 | Completed | Kyowa Kirin Co., Ltd. | 24 | 2019-12-03 | 2022-05-26 |
| Study of AMG531(Romiplostim) in Patients With Aplastic Anemia Romiplostim - Aplastic Anemia | Phase 2 / Phase 3 | Completed | Kyowa Kirin Co., Ltd. | 17 | 2019-04-25 | 2022-05-26 |
| Posaconazole Prophylaxis During ATG Treatment for hMDS/AA Patients Posaconazole - Aplastic Anemia, Myelodysplastic Syndromes | Phase 2 | Completed | Seoul National University Hospital | 20 | 2018-04-20 | 2024-12-20 |
| A Phase II Dose-escalation Study Characterizing the PK of Eltrombopag in Pediatric Patients With Previously Untreated or Relapsed Severe Aplastic Anemia or Recurrent Aplastic Anemia Eltrombopag, hATG, CsA - Aplastic Anemia | Phase 2 | Completed | Novartis Pharmaceuticals | 51 | 2017-09-30 | 2026-08-10 |
| NMA Haplo or MUD BMT for Newly Diagnosed Severe Aplastic Anemia Thymoglobulin, Fludarabine, Cyclophosphamide - Severe Aplastic Anemia, Aplastic Anemia | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 21 | 2016-09-01 | 2022-07-12 |
| Study of Romiplostim(AMG531) in Subjects With Aplastic Anemia Romiplostim - Aplastic Anemia | Phase 2 / Phase 3 | Completed | Kyowa Kirin Co., Ltd. | 46 | 2016-05-01 | 2024-07-16 |
| Reduced Intensity Chemotherapy and Radiation Therapy Before Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies Fludarabine, Total-Body Irradiation, T Cell-Depleted Donor Lymphocyte Infusion - Acute Myeloid Leukemia, Acute Myeloid Leukemia in Remission | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 35 | 2015-11-13 | 2025-04-24 |
| Phase IIA Open Label Study to Evaluate Efficacy and Safety of BL-8040 Followed by (hATG), Cyclosporine and Methyprednisolone in Adult Subjects With Aplastic Anemia or Hypoplastic Myelodysplastic Syndrome BL-8040, horse anti-thymocyte globulin (hATG), Methylprednisolone - Aplastic Anemia, Hypoplastic Myelodysplastic Syndrome | Phase 2 | Completed | BioLineRx, Ltd. | 11 | 2015-10-01 | 2020-12-29 |
| Eltrombopag in Combination With Rabbit Anti-thymocyte Globulin/Cyclosporine A in Naive Aplastic Anemia (AA) Subjects Eltrombopag, Rabbit ATG, CsA - Aplastic Anemia | Phase 2 | Completed | Novartis Pharmaceuticals | 10 | 2015-05-12 | 2019-07-26 |
| A Single-Arm Phase 2 Study With Optimized Standard Protocol for Severe Aplastic Anemia rabbit ATG, Cyclosporine, Levamisole - Aplastic Anemia | Phase 2 | Completed | Institute of Hematology & Blood Diseases Hospital, China | 40 | 2014-08-01 | 2026-02-11 |
| A Phase 2 Study to Evaluate the Efficacy and Safety of AMG531 in Aplastic Anemia AMG531 - Aplastic Anemia | Phase 2 | Completed | Kyowa Kirin Korea Co., Ltd. | 35 | 2014-04-14 | 2024-04-30 |
| Nandrolone Decanoate in the Treatment of Telomeropathies Nandrolone Decanoate - Aplastic Anemia, Bone Marrow Failure Syndromes | Phase 1 / Phase 2 | Completed | University of Sao Paulo | 20 | 2014-02-01 | 2023-08-31 |
| Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in With High-Risk Hematologic Malignancies Fludarabine phosphate, Busulfan, Total-Body Irradiation - Acute Myeloid Leukemia With FLT3/ITD Mutation, Acute Myeloid Leukemia With Gene Mutations | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 62 | 2012-12-24 | 2025-10-30 |
| Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies fludarabine phosphate, melphalan, total-body irradiation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Roswell Park Cancer Institute | 94 | 2012-02-28 | 2019-09-24 |
| A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies Fludarabine, Busulfan, Total Body Irradiation (TBI) - Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 40 | 2011-08-04 | 2026-04-15 |
| Danazol for Genetic Bone Marrow and Lung Disorders Danazol - Aplastic Anemia | Phase 1 / Phase 2 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 27 | 2011-07-19 | 2018-08-15 |
| Mesenchymal Stem Cells in the Treatment of Relapsed/Refractory Severe Acquired Aplastic Anemia Intravenous bone marrow mesenchymal stem cells infusion - Aplastic Anemia | Phase 1 / Phase 2 | Completed | University of Sao Paulo | 9 | 2011-02-01 | 2014-02-04 |
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Anemia, Aplastic (38) · Myelodysplastic Syndromes (9) · Hodgkin Disease (8) · Multiple Myeloma (7) · Leukemia, Myeloid, Acute (6) · Myeloproliferative Disorders (6) · Leukemia, Lymphocytic, Chronic, B-Cell (5) · Leukemia, Myelomonocytic, Chronic (5) · Lymphoma, Follicular (4) · Lymphoma, Non-Hodgkin (4) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (4) · Primary Myelofibrosis (4) · Recurrence (4) · Anemia, Refractory (3) · Autoimmune Diseases (3)
Bone Marrow Diseases (38) · Hemic and Lymphatic Diseases (38) · Anemia (36) · Bone Marrow Failure Disorders (35) · Hematologic Diseases (35) · Pathologic Processes (12) · Pathological Conditions, Signs and Symptoms (12) · Immune System Diseases (11) · Disease Attributes (10) · Neoplasms (9) · Neoplasms by Histologic Type (9) · Immunoproliferative Disorders (8) · Lymphatic Diseases (8) · Lymphoproliferative Disorders (8) · Blood Protein Disorders (7)
Cyclophosphamide (16) · Cyclosporine (13) · Antilymphocyte Serum (10) · fludarabine (9) · Mycophenolic Acid (8) · Tacrolimus (8) · fludarabine phosphate (8) · thymoglobulin (8) · Whole-Body Irradiation (7) · Methylprednisolone (5) · Peripheral Blood Stem Cell Transplantation (5) · Methotrexate (4) · romiplostim (4) · Alemtuzumab (3) · Busulfan (3)
National Heart, Lung, and Blood Institute (NHLBI) (5) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (4) · Kyowa Kirin Co., Ltd. (3) · Novartis Pharmaceuticals (3) · Beth Israel Deaconess Medical Center (2) · Roswell Park Cancer Institute (2) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2) · University of Sao Paulo (2) · Asan Medical Center (1) · Bing Han (1) · BioLineRx, Ltd. (1) · European Society for Blood and Marrow Transplantation (1) · Fred Hutchinson Cancer Center (1) · Institute of Hematology & Blood Diseases Hospital, China (1) · Joanne Kurtzberg, MD (1)
United States (23) · China (4) · Japan (4) · South Korea (4) · Brazil (2) · United Kingdom (2) · France (1) · Germany (1) · Hong Kong (1) · Italy (1) · Portugal (1) · Russia (1) · Saudi Arabia (1) · Switzerland (1) · Thailand (1)
Danielle M Townsley, M.D. (3) · David E Avigan, MD (2) · David F McDermott, MD (2) · Neal Flomenberg, MD (2) · Usama Gergis, MD (2) · Amy E DeZern, MD (1) · Ana Beatriz Hortense, MD (1) · Dolores Grosso, DNP, CRNP (1) · Dolores Grosso, RN, CRNP, DNP (1) · Faird Boulad, MD (1) · George Chen (1) · Ho Joon Im, MD & PhD (1) · Jakub Tolar, M.D., Ph.D. (1)
PMID 40593138, PMID 1090310, PMID 12622583, PMID 20383216, PMID 21606164, PMID 22055111, PMID 22067384, PMID 22544699, PMID 25185712, PMID 25310303, PMID 26589752, PMID 27192671, PMID 28179273, PMID 31474546, PMID 31851762, PMID 32343796, PMID 34724566, PMID 36579443, PMID 37084383, PMID 37919313, PMID 40315366, PMID 42057135
2015 (1), P01HL036444 (1)