12 completed, 6 unknown, 3 terminated, 2 recruiting. 25 Phase 1, 16 Phase 2.
Follow Aplastic Anemia: new trials by email Literature Review of Aplastic Anemia trials Research Report on Aplastic Anemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase I/II Study of Anti-CD38 Monoclonal Antibody in Refractory Severe Aplastic Anemia Isatuximab - Aplastic Anemia | Phase 1 / Phase 2 | Recruiting | Institute of Hematology & Blood Diseases Hospital, China | 32 | 2026-06-30 | 2026-09-21 |
| The Safety and Efficacy of Daratumumab in Patients With Refractory Aplastic Anemia Daratumumab - Aplastic Anemia, Refractory | Phase 1 / Phase 2 | Recruiting | Institute of Hematology & Blood Diseases Hospital, China | 37 | 2025-12-17 | 2026-11-06 |
| Study of CM313(SC) Injection in Subjects With Relapsed/Refractory Aplastic Anemia CM313(SC) injection - Aplastic Anemia | Phase 1 / Phase 2 | Not yet recruiting | Keymed Biosciences Co.Ltd | 125 | 2025-03-01 | 2025-02-18 |
| Efficacy of Daratumumab to Overcome Platelet Transfusion Refractoriness in Patients with Aplastic Anemia Daratumumab - Aplastic Anemia, Platelet Transfusion Refractoriness | Phase 1 | Completed | Institute of Hematology & Blood Diseases Hospital, China | 10 | 2023-04-17 | 2025-01-03 |
| Autologous Tregs for Aplastic Anaemia Expanded autologous T regulatory cells - Aplastic Anemia | Phase 1 | Unknown | King's College Hospital NHS Trust | 12 | 2022-07-14 | 2023-10-05 |
| Ibrutinib for the Treatment of COVID-19 in Patients Requiring Hospitalization Best Practice, Ibrutinib - Aplastic Anemia, Hematopoietic and Lymphoid Cell Neoplasm | Phase 1 | Completed | Jennifer Woyach | 10 | 2020-10-23 | 2023-12-26 |
| Cytokine-Treated Veto Cells in Treating Patients With Hematologic Malignancies Following Stem Cell Transplant Anti-Thymocyte Globulin, Cyclophosphamide, Cytokine-treated Veto Cells - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 1 / Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 16 | 2019-08-08 | 2026-06-11 |
| Engineered Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies Cyclophosphamide, Filgrastim, Fludarabine Phosphate - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 1 | Completed | M.D. Anderson Cancer Center | 11 | 2017-01-18 | 2023-02-16 |
| Umbilical Cord Derived Mesenchymal Stem Cells Therapy in Aplastic Anemia mesenchymal stem cells - Aplastic Anemia | Phase 1 | Unknown | Hebei Medical University | 10 | 2017-01-01 | 2017-04-07 |
| Nandrolone Decanoate in the Treatment of Telomeropathies Nandrolone Decanoate - Aplastic Anemia, Bone Marrow Failure Syndromes | Phase 1 / Phase 2 | Completed | University of Sao Paulo | 20 | 2014-02-01 | 2023-08-31 |
| Open-label Clinical Trial to Investigate the Safety and Tolerability of Allogeneic B-cell Concentrates for Immune Reconstitution After Allogeneic Stem Cell Transplantation Measured as Response to a Antedated Single Vaccination allogeneic donor derived B-lymphocytes - Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia | Phase 1 / Phase 2 | Unknown | University of Erlangen-Nürnberg Medical School | 15 | 2013-11-01 | 2014-03-26 |
| Danazol for Genetic Bone Marrow and Lung Disorders Danazol - Aplastic Anemia | Phase 1 / Phase 2 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 27 | 2011-07-19 | 2018-08-15 |
| Alefacept in Patients With Relapsed/Refractory Aplastic Anemia Alefacept - Aplastic Anemia | Phase 1 | Terminated | The Cleveland Clinic | 4 | 2011-05-01 | 2018-01-26 |
| Mesenchymal Stem Cells in the Treatment of Relapsed/Refractory Severe Acquired Aplastic Anemia Intravenous bone marrow mesenchymal stem cells infusion - Aplastic Anemia | Phase 1 / Phase 2 | Completed | University of Sao Paulo | 9 | 2011-02-01 | 2014-02-04 |
| Mesenchymal Stem Cells Transplantation to Patients With Relapsed/Refractory Aplastic Anemia. bone marrow derived mesenchymal stem cells - Aplastic Anemia | Phase 1 / Phase 2 | Unknown | Guangzhou General Hospital of Guangzhou Military Command | 50 | 2011-02-01 | 2011-03-01 |
| Cyclophosphamide Plus Cyclosporine in Treatment-Naive Severe Aplastic Anemia Cyclophosphamide, Cyclosporine - Aplastic Anemia, Neutropenia | Phase 1 / Phase 2 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 22 | 2010-08-01 | 2017-05-22 |
| A Pilot Study of Fludarabine Plus Cyclophosphamide in Refractory Severe Aplastic Anemia Cyclophosphamide, Fludarabine - Aplastic Anemia, Neutropenia | Phase 1 / Phase 2 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 1 | 2010-08-01 | 2021-07-02 |
| Human Leukocyte Antigen (HLA)-Haploidentical Hematopoietic Stem Cell Transplantation for Patients With Aplastic Anemia anti-thymocyte globulin, filgrastim, Fludarabine - Aplastic Anemia | Phase 1 / Phase 2 | Completed | Asan Medical Center | 12 | 2009-07-01 | 2013-01-03 |
| Study of Fludarabine + Cyclophosphamide + TBI Conditioning Regimen for Double Units Cord Blood Transplantation(CBT)in Severe Aplastic Anemia(SAA) Cyclophosphosphamide, TBI - Aplastic Anemia | Phase 1 / Phase 2 | Unknown | The Korean Society of Pediatric Hematology Oncology | 5 | 2008-11-01 | 2012-03-26 |
| Treatment of Menorrhagia in Women With Thrombocytopenia Using Platelets or Platelets and Hormones Lo-Ovral Oral Contraceptive Pills, Placebo - sugar pill - Aplastic Anemia, Menorrhagia | Phase 1 / Phase 2 | Terminated | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 1 | 2007-11-01 | 2013-07-19 |
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Anemia, Aplastic (25) · Myelodysplastic Syndromes (5) · Bone Marrow Failure Disorders (3) · Hodgkin Disease (3) · Leukemia, Myeloid, Acute (3) · Lymphoma, Non-Hodgkin (3) · Multiple Myeloma (3) · Pancytopenia (3) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (3) · Hematologic Neoplasms (2) · Leukemia, Lymphocytic, Chronic, B-Cell (2) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (2) · Myeloproliferative Disorders (2) · Neutropenia (2) · Amenorrhea (1)
Anemia (25) · Bone Marrow Diseases (25) · Hematologic Diseases (25) · Hemic and Lymphatic Diseases (25) · Bone Marrow Failure Disorders (22) · Pathologic Processes (6) · Pathological Conditions, Signs and Symptoms (6) · Immune System Diseases (5) · Neoplasms (5) · Blood Protein Disorders (4) · Cytopenia (4) · Disease Attributes (4) · Immunoproliferative Disorders (4) · Paraproteinemias (4) · Cardiovascular Diseases (3)
Cyclophosphamide (6) · Whole-Body Irradiation (4) · Antilymphocyte Serum (3) · Filgrastim (3) · Granulocyte Colony-Stimulating Factor (3) · fludarabine (3) · Cyclosporine (2) · Cyclosporins (2) · Peripheral Blood Stem Cell Transplantation (2) · daratumumab (2) · Alefacept (1) · Blood Component Removal (1) · CT-P10 (1) · Cord Blood Stem Cell Transplantation (1) · Danazol (1)
National Heart, Lung, and Blood Institute (NHLBI) (5) · Institute of Hematology & Blood Diseases Hospital, China (3) · M.D. Anderson Cancer Center (2) · University of Sao Paulo (2) · Asan Medical Center (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Fred Hutchinson Cancer Center (1) · Guangzhou General Hospital of Guangzhou Military Command (1) · Hebei Medical University (1) · Jennifer Woyach (1) · Joanne Kurtzberg, MD (1) · Keymed Biosciences Co.Ltd (1) · King's College Hospital NHS Trust (1) · The Cleveland Clinic (1) · The Korean Society of Pediatric Hematology Oncology (1)
United States (12) · China (6) · Brazil (2) · Germany (2) · South Korea (2) · Austria (1) · United Kingdom (1)
Danielle M Townsley, M.D. (2) · Ana Beatriz Hortense, MD (1) · Ann Woolfrey (1) · Baoyong Yan, Doctor (1) · Bing Ma, Master (1) · Bojian Sun, Master (1) · Dan Zhao, Master (1) · Fan Zhang, Bachelor (1) · Ghulam Mufti (1) · Ho Joon Im, MD & PhD (1) · Hyo Seop Ahn, M.D, Ph.D (1) · Jennifer A Woyach, MD (1) · Joanne Kurtzberg, MD (1)
PMID 22055111, PMID 23731760, PMID 25185712, PMID 25310303, PMID 26589752, PMID 27192671, PMID 34724566, PMID 36579443, PMID 38467031, PMID 40331918, PMID 41742894