12 completed. 12 Phase 1, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 12 | Completed 12 |
| Phase 2 | 7 | Completed 7 |
Follow Aplastic Anemia: new trials by email Literature Review of Aplastic Anemia trials Research Report on Aplastic Anemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Daratumumab to Overcome Platelet Transfusion Refractoriness in Patients with Aplastic Anemia Daratumumab - Aplastic Anemia, Platelet Transfusion Refractoriness | Phase 1 | Completed | Institute of Hematology & Blood Diseases Hospital, China | 10 | 2023-04-17 | 2025-01-03 |
| Ibrutinib for the Treatment of COVID-19 in Patients Requiring Hospitalization Best Practice, Ibrutinib - Aplastic Anemia, Hematopoietic and Lymphoid Cell Neoplasm | Phase 1 | Completed | Jennifer Woyach | 10 | 2020-10-23 | 2023-12-26 |
| Engineered Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies Cyclophosphamide, Filgrastim, Fludarabine Phosphate - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 1 | Completed | M.D. Anderson Cancer Center | 11 | 2017-01-18 | 2023-02-16 |
| Nandrolone Decanoate in the Treatment of Telomeropathies Nandrolone Decanoate - Aplastic Anemia, Bone Marrow Failure Syndromes | Phase 1 / Phase 2 | Completed | University of Sao Paulo | 20 | 2014-02-01 | 2023-08-31 |
| Danazol for Genetic Bone Marrow and Lung Disorders Danazol - Aplastic Anemia | Phase 1 / Phase 2 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 27 | 2011-07-19 | 2018-08-15 |
| Mesenchymal Stem Cells in the Treatment of Relapsed/Refractory Severe Acquired Aplastic Anemia Intravenous bone marrow mesenchymal stem cells infusion - Aplastic Anemia | Phase 1 / Phase 2 | Completed | University of Sao Paulo | 9 | 2011-02-01 | 2014-02-04 |
| Cyclophosphamide Plus Cyclosporine in Treatment-Naive Severe Aplastic Anemia Cyclophosphamide, Cyclosporine - Aplastic Anemia, Neutropenia | Phase 1 / Phase 2 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 22 | 2010-08-01 | 2017-05-22 |
| A Pilot Study of Fludarabine Plus Cyclophosphamide in Refractory Severe Aplastic Anemia Cyclophosphamide, Fludarabine - Aplastic Anemia, Neutropenia | Phase 1 / Phase 2 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 1 | 2010-08-01 | 2021-07-02 |
| Human Leukocyte Antigen (HLA)-Haploidentical Hematopoietic Stem Cell Transplantation for Patients With Aplastic Anemia anti-thymocyte globulin, filgrastim, Fludarabine - Aplastic Anemia | Phase 1 / Phase 2 | Completed | Asan Medical Center | 12 | 2009-07-01 | 2013-01-03 |
| Unrelated Cord Blood Transplant Plus a Haplo-Identical (Half-Matched), T-Cell Depleted Stem Transplant From a Related Donor for Subjects With High Risk Malignancies haplo/cord transplant - Hematologic Malignancy, Myelodysplastic Syndrome (MDS) | Phase 1 / Phase 2 | Completed | Joanne Kurtzberg, MD | 3 | 2007-08-01 | 2015-04-03 |
| Stem Cell Mobilization Potential in Patients With Aplastic Anemia in Remission G-CSF, Apheresis - Aplastic Anemia | Phase 1 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 20 | 2001-02-01 | 2008-03-04 |
| Stem Cell Factor Medication for Aplastic Anemia Recombinant Methionyl Human Stem Cell Factor (r-metHuSCF) - Aplastic Anemia, Pancytopenia | Phase 1 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 40 | 1993-10-01 | 2008-03-04 |
Anemia, Aplastic (12) · Myelodysplastic Syndromes (3) · Pancytopenia (3) · Bone Marrow Failure Disorders (2) · Hematologic Neoplasms (2) · Neutropenia (2) · Autoimmune Diseases (1) · Blast Crisis (1) · Hodgkin Disease (1) · Idiopathic Pulmonary Fibrosis (1) · Leukemia, Lymphocytic, Chronic, B-Cell (1) · Leukemia, Myeloid, Acute (1) · Leukemia, Myeloid, Chronic-Phase (1) · Leukemia, Myelomonocytic, Chronic (1) · Liver Cirrhosis (1)
Anemia (12) · Bone Marrow Diseases (12) · Hematologic Diseases (12) · Hemic and Lymphatic Diseases (12) · Bone Marrow Failure Disorders (10) · Cytopenia (3) · Immune System Diseases (3) · Neoplasms (3) · Agranulocytosis (2) · Blood Protein Disorders (2) · Immunoproliferative Disorders (2) · Leukocyte Disorders (2) · Leukopenia (2) · Lung Diseases (2) · Lung Diseases, Interstitial (2)
Cyclophosphamide (4) · Filgrastim (2) · Granulocyte Colony-Stimulating Factor (2) · fludarabine (2) · Antilymphocyte Serum (1) · Blood Component Removal (1) · CT-P10 (1) · Cyclosporine (1) · Cyclosporins (1) · Danazol (1) · Influenza Vaccines (1) · Melphalan (1) · Nandrolone Decanoate (1) · Peripheral Blood Stem Cell Transplantation (1) · Practice Guidelines as Topic (1)
National Heart, Lung, and Blood Institute (NHLBI) (5) · University of Sao Paulo (2) · Asan Medical Center (1) · Institute of Hematology & Blood Diseases Hospital, China (1) · Jennifer Woyach (1) · Joanne Kurtzberg, MD (1) · M.D. Anderson Cancer Center (1)
United States (8) · Brazil (2) · China (1) · South Korea (1)
Danielle M Townsley, M.D. (2) · Ana Beatriz Hortense, MD (1) · Ho Joon Im, MD & PhD (1) · Jennifer A Woyach, MD (1) · Joanne Kurtzberg, MD (1) · Neal S Young, M.D. (1) · Rodrigo T Calado, MD (1) · Rodrigo T Calado, MD, PhD (1) · Samer Srour (1)
PMID 22055111, PMID 25185712, PMID 25310303, PMID 26589752, PMID 27192671, PMID 34724566, PMID 36579443, PMID 40331918