15 unknown. 15 Phase 1, 10 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 15 | Unknown 15 |
| Phase 2 | 10 | Unknown 10 |
Follow Anemia, Aplastic: new trials by email Literature Review of Anemia, Aplastic trials Research Report on Anemia, Aplastic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sirolimus+Abatacept+Mycophenolate Mofetil for Prophylaxis of aGVHD in Patients Receiving Haplo-HSCT Who Are Intolerant to Calcineurin Inhibitors Sirolimus, Abatacept, MMF - Acute Leukemia, Myelodysplastic Syndromes | Phase 1 / Phase 2 | Unknown | Peking University People's Hospital | 6 | 2024-03-01 | 2024-03-21 |
| Autologous Tregs for Aplastic Anaemia Expanded autologous T regulatory cells - Aplastic Anemia | Phase 1 | Unknown | King's College Hospital NHS Trust | 12 | 2022-07-14 | 2023-10-05 |
| Transfer of Effector Memory T Cells (Tem) Following Allogeneic Stem Cell Transplantation CD62L- Tem - Lymphoma, Leukemia | Phase 1 | Unknown | University College, London | 18 | 2019-10-21 | 2019-10-25 |
| Umbilical Cord Derived Mesenchymal Stem Cells Therapy in Aplastic Anemia mesenchymal stem cells - Aplastic Anemia | Phase 1 | Unknown | Hebei Medical University | 10 | 2017-01-01 | 2017-04-07 |
| Safety and Efficacy of Patient's Own AD-MSC and AD-HSC Transplantation in Patients With Severe Aplastic Anemia Rabbit antithymoglobulin (ATG), Adipose derived mesenchymal stem cells ( AD-MSCs), AD-MSC transdifferentiated HSCs (AD-HSCs) - Severe Aplastic Anemia | Phase 1 / Phase 2 | Unknown | Navy General Hospital, Beijing | 90 | 2015-01-01 | 2015-04-03 |
| Effectiveness and Safety of MMSCs for Enhancing Hematopoietic Recovery and Prophylaxis of Neutropenic Enterocolitis Peripheral blood stem cell mobilisation and collection, High-dose chemotherapy, Bone marrow derived allogeneic MMSCs infusion - Neutropenic Enterocolitis, Myeloablative Chemotherapy Induced Bone Marrow Aplasia | Phase 1 / Phase 2 | Unknown | Burnasyan Federal Medical Biophysical Center | 16 | 2014-05-01 | 2015-06-10 |
| Open-label Clinical Trial to Investigate the Safety and Tolerability of Allogeneic B-cell Concentrates for Immune Reconstitution After Allogeneic Stem Cell Transplantation Measured as Response to a Antedated Single Vaccination allogeneic donor derived B-lymphocytes - Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia | Phase 1 / Phase 2 | Unknown | University of Erlangen-Nürnberg Medical School | 15 | 2013-11-01 | 2014-03-26 |
| CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant CliniMACS CD34+ Reagent System, Thiotepa, Cyclophosphamide - Chronic Myeloid Leukemia (CML), Acute Myelogenous Leukemia (AML) | Phase 1 / Phase 2 | Unknown | Diane George | 14 | 2013-06-03 | 2024-06-04 |
| Mesenchymal Stem Cells Transplantation to Patients With Relapsed/Refractory Aplastic Anemia. bone marrow derived mesenchymal stem cells - Aplastic Anemia | Phase 1 / Phase 2 | Unknown | Guangzhou General Hospital of Guangzhou Military Command | 50 | 2011-02-01 | 2011-03-01 |
| Study of Fludarabine + Cyclophosphamide + TBI Conditioning Regimen for Double Units Cord Blood Transplantation(CBT)in Severe Aplastic Anemia(SAA) Cyclophosphosphamide, TBI - Aplastic Anemia | Phase 1 / Phase 2 | Unknown | The Korean Society of Pediatric Hematology Oncology | 5 | 2008-11-01 | 2012-03-26 |
| Sirolimus and Cyclosporine for Treatment-Resistant Aplastic Anemia Sirolimus, Cyclosporine - Anemia, Aplastic | Phase 1 / Phase 2 | Unknown | Office of Rare Diseases (ORD) | 52 | 2006-05-01 | 2008-10-07 |
| Safety Study of CD3/CD19 Depleted Haploidentical Stem Cells Transplantation of CD3/CD19 depleted stem cells - Acute Leukemias, Aplastic Anemia | Phase 1 / Phase 2 | Unknown | University Children's Hospital Tuebingen | 120 | 2004-03-01 | 2014-10-08 |
| Safety and Efficacy Study of Ex Vivo Immunotherapy for Treatment of Aplastic Anemia Ex Vivo Immunotherapy, Ex vivo immunotherapy - Anemia, Aplastic | Phase 1 / Phase 2 | Unknown | Shenzhen Zhongxing Yangfan Biotech Co. Ltd. | 100 | 2002-11-01 | 2008-11-11 |
| Phase I Study of Amifostine in Patients With Bone Marrow Failure Related to Fanconi's Anemia amifostine - Fanconi's Anemia | Phase 1 | Unknown | Dana-Farber Cancer Institute | 21 | 2000-04-01 | 2005-06-24 |
| Phase I Pilot Study of CD34 Enriched, Fanconi's Anemia Complementation Group C Gene Transduced Autologous Peripheral Blood Stem Cell Transplantation in Patients With Fanconi's Anemia filgrastim, Autologous stem cells transduced with FACC retroviral vector, Autologous Stem Cell Transplantation - Fanconi's Anemia | Phase 1 | Unknown | University of Minnesota | 6 | 2000-03-01 | 2005-06-24 |
Myelodysplastic Syndromes (4) · Fanconi Anemia (2) · Graft vs Host Disease (2) · Hematologic Diseases (2) · Hodgkin Disease (2) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (2) · Leukemia, Myeloid, Acute (2) · Lymphoma (2) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (2) · Primary Immunodeficiency Diseases (2) · Rare Diseases (2) · Acquired Immunodeficiency Syndrome (1) · Anemia, Diamond-Blackfan (1) · Anemia, Sickle Cell (1)
Anemia (15) · Bone Marrow Diseases (15) · Hemic and Lymphatic Diseases (15) · Bone Marrow Failure Disorders (14) · Hematologic Diseases (13) · Immune System Diseases (5) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (4) · Disease Attributes (4) · Genetic Diseases, Inborn (4) · Immunoproliferative Disorders (4) · Lymphatic Diseases (4) · Lymphoproliferative Disorders (4) · Neoplasms (4) · Neoplasms by Histologic Type (4) · Pathologic Processes (4)
Sirolimus (2) · Abatacept (1) · Alemtuzumab (1) · Amifostine (1) · Busulfan (1) · Cyclophosphamide (1) · Cyclosporine (1) · Drug Therapy (1) · Filgrastim (1) · Melphalan (1) · Methylprednisolone (1) · Methylprednisolone Hemisuccinate (1) · Tacrolimus (1) · Thiotepa (1) · Whole-Body Irradiation (1)
Burnasyan Federal Medical Biophysical Center (1) · Dana-Farber Cancer Institute (1) · Diane George (1) · Guangzhou General Hospital of Guangzhou Military Command (1) · Hebei Medical University (1) · King's College Hospital NHS Trust (1) · Navy General Hospital, Beijing (1) · Office of Rare Diseases (ORD) (1) · Peking University People's Hospital (1) · Shenzhen Zhongxing Yangfan Biotech Co. Ltd. (1) · The Korean Society of Pediatric Hematology Oncology (1) · University Children's Hospital Tuebingen (1) · University College, London (1) · University of Erlangen-Nürnberg Medical School (1) · University of Minnesota (1)
China (4) · United States (3) · Germany (2) · United Kingdom (2) · Austria (1) · Russia (1) · South Korea (1)
Baoyong Yan, Doctor (1) · Bing Ma, Master (1) · Bojian Sun, Master (1) · Dan Zhao, Master (1) · Demao Yang, PhD (1) · Diane George, MD (1) · Fan Zhang, Bachelor (1) · Ghulam Mufti (1) · Hyo Seop Ahn, M.D, Ph.D (1) · Ilya I Eremin, MD, PhD (1) · John E. Wagner, Jr. (1) · Julia Winkler, MD (1) · Peter Lang, MD (1) · Qingchi Liu, Doctor (1) · Quanhai Li, Doctor (1)
PMID 23731760, PMID 38467031, PMID 41742894
U54RR019397 (1)