19 completed, 11 recruiting, 5 unknown, 4 not yet recruiting. 48 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 48 | Completed 19, Recruiting 11, Unknown 5, Not yet recruiting 4, Terminated 4, Withdrawn 3, Active not recruiting 1, Enrolling by invitation 1 |
Follow Anemia: new trials by email Literature Review of Anemia trials Research Report on Anemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CS-206 in Patients With Sickle Cell Disease CS-206 - Sickle Cell Disease | Early Phase 1 | Not yet recruiting | Children's Hospital of Fudan University | 5 | 2026-09-30 | 2026-05-15 |
| META 10-19 in Patients With Relapsed/Refractory Autoimmune Hemolytic Anemia Metabolically Armed Autologous CD19 CAR T-Cell therapy - Autoimmune Hemolytic Anemia (AIHA) | Early Phase 1 | Not yet recruiting | Institute of Hematology & Blood Diseases Hospital, China | 18 | 2026-09-20 | 2026-09-21 |
| A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CTX001 in Healthy Adults. CTX001 With and Without Iron, CTX001 With Iron, CTX001 Multiple Dose - Anemia, Iron Deficiencies | Early Phase 1 | Recruiting | Cajal Therapeutics Inc. | 72 | 2026-06-01 | 2026-06-12 |
| Evaluation of Safety, Pharmacokinetics and Pharmacodynamics of Arnovie101, an mRNA-LNP-Based In Vivo CAR-T Therapy, for the Treatment of B Cell-Mediated Autoimmune Diseases (SLE and AIHA) Arnovie101 Infusion Intravenous - Systemic Lupus Erythematosus, Autoimmune Hemolytic Anemia (AIHA) | Early Phase 1 | Recruiting | Circunited BioPharma (Shenzhen) Co., Ltd. | 5 | 2026-04-07 | 2026-06-05 |
| UCAR-T Targeting CD19/BCMA in Subjects With Autoantibody-Mediated Autoimmune Benign Hematological Diseases CART Infusion - Autoimmune Hemolytic Anemia, Primary Immune Thrombocytopenic Purpura | Early Phase 1 | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 27 | 2026-02-03 | 2026-03-02 |
| YOLT-204 in Patients With Hemoglobinopathies YOLT-204 - Hemoglobinopathies (Transfusion-dependent β-thalassemia and Sickle Cell Disease) | Early Phase 1 | Not yet recruiting | Guangzhou Women and Children's Medical Center | 18 | 2025-09-30 | 2025-09-24 |
| A Clinical Study Evaluating the Safety and Efficacy of GT801 Injection in Adult Patients With Relapsed/Refractory CD19-positive B-cell Hematologic Malignancies and Autoimmune Hemolytic Anemia GT801 Injection - B-cell Acute Lymphoblastic Leukemia (B-ALL), Chronic Lymphocytic Leukemia (CLL) | Early Phase 1 | Recruiting | Grit Biotechnology | 28 | 2025-09-26 | 2026-07-20 |
| UCAR T-cell Therapy Targeting CD19/BCMA in Patients With r/r Autoimmune Hemolytic Anemia UCAR T-cell group - Relapsed / Refractory Autoimmune Hemolytic Anemia | Early Phase 1 | Not yet recruiting | Zhejiang University | 18 | 2025-04-03 | 2025-04-09 |
| A Study of LCAR-AIO in Subjects With Relapsed/Refractory Systemic Lupus Erythematosus LCAR-AIO T cells - Systemic Lupus Erythematosus (SLE) | Early Phase 1 | Completed | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 3 | 2025-01-08 | 2026-10-14 |
| Safety Study of CC312 in Autoimmune Disease Patients CC312 - Systemic Lupus Erythematosus (SLE), Idiopathic Inflammatory Myopathy (IIM) | Early Phase 1 | Recruiting | CytoCares Inc | 18 | 2024-11-08 | 2025-09-17 |
| CD7 CAR-T Bridging to alloHSCT for Severe Aplastic Anemia CD7 CAR-T cells injection, Allogeneic hematopoietic stem cell transplantation - Aplastic Anemia | Early Phase 1 | Recruiting | Zhejiang University | 30 | 2024-10-20 | 2024-10-09 |
| Darzalex Faspro (Daratumumab and Hyaluronidase-fihj) Before Standard Desensitization and Allogeneic Bone Marrow or Peripheral Blood Stem Cell Transplantation in Adult Patients at High-risk for Primary Graft Failure Secondary to Donor Specific Antibodies Darzalex Faspro (Daratumumab and hyaluronidase-fihj), JH-DSA Semi-Quant Screen and Response Score - Hematologic Malignancy, Bone Marrow Transplant Rejection | Early Phase 1 | Recruiting | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 8 | 2024-09-19 | 2026-10-05 |
| CS-206 in Patients With Sickle Cell Disease CS-206 - Sickle Cell Disease | Early Phase 1 | Recruiting | CorrectSequence Therapeutics Co., Ltd | 5 | 2024-09-02 | 2026-02-10 |
| Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling Biotin-labeled red blood cells - Sickle Cell Disease, Thalassemia | Early Phase 1 | Recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 100 | 2024-05-17 | 2026-09-28 |
| CS-101 in Patients With β-thalassemia CS-101 - Beta-Thalassemia | Early Phase 1 | Enrolling by invitation | CorrectSequence Therapeutics Co., Ltd | 10 | 2024-03-19 | 2026-06-09 |
| Base-edited Autologous Hematopoietic Stem Cell Transplantation in Treating Patients With β-thalassemia Major CS-101 injection - Beta-Thalassemia | Early Phase 1 | Completed | Children's Hospital of Fudan University | 2 | 2023-11-07 | 2026-05-15 |
| Safety and Efficacy of RM-004 Cells for Hemoglobin H-Constant Spring Disease RM-004 - Alpha Thalassemia Hemoglobin H Constant Spring, Hemoglobinopathies | Early Phase 1 | Recruiting | The 923rd Hospital of Joint Logistics Support Force of People's Liberation Army | 5 | 2023-10-08 | 2024-06-03 |
| A Clinical Study Evaluating the Safety and Efficacy of CS-101 in Treating Subjects With β-thalassemia CS-101 - Beta-Thalassemia | Early Phase 1 | Completed | CorrectSequence Therapeutics Co., Ltd | 5 | 2023-08-26 | 2026-02-12 |
| A Study Evaluating the Safety and Efficacy of LentiRed Drug Product in Transfusion-dependent β-Thalassemia [TDT] GMCN-508B (LentiRed) - Transfusion Dependent Beta-Thalassemia | Early Phase 1 | Recruiting | First Affiliated Hospital of Guangxi Medical University | 5 | 2023-02-22 | 2023-05-09 |
| Effects of N-acetyl Cystein (NAC) Supplementation in G6PD Deficient Individuals After Acute Exercise N-acetyl cystein, Placebo - G6PD Deficiency | Early Phase 1 | Unknown | University of Thessaly | 12 | 2023-02-01 | 2022-01-05 |
Showing 20 of 48. Sign in to see all of them.
Anemia, Sickle Cell (15) · Anemia, Hemolytic, Autoimmune (8) · beta-Thalassemia (5) · Anemia, Aplastic (4) · Anemia, Iron-Deficiency (4) · Hemoglobinopathies (4) · Anemia, Refractory, with Excess of Blasts (3) · Lupus Erythematosus, Systemic (3) · Myelodysplastic Syndromes (3) · Thalassemia (3) · Genetic Diseases, Inborn (2) · Hematologic Diseases (2) · Iron Deficiencies (2) · Lymphoma (2)
Hemic and Lymphatic Diseases (47) · Hematologic Diseases (46) · Anemia, Hemolytic (31) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (26) · Anemia, Hemolytic, Congenital (23) · Genetic Diseases, Inborn (23) · Hemoglobinopathies (18) · Immune System Diseases (11) · Bone Marrow Diseases (8) · Metabolic Diseases (8) · Nutritional and Metabolic Diseases (8) · Autoimmune Diseases (7) · Pathological Conditions, Signs and Symptoms (7) · Pathologic Processes (6)
ferrous sulfate (3) · Hydroxyurea (2) · Iron (2) · ferrous fumarate (2) · Alemtuzumab (1) · Antilymphocyte Serum (1) · Biopsy (1) · Blood Transfusion (1) · Bortezomib (1) · Busulfan (1) · CT-P10 (1) · Calcitriol (1) · Calcium Dobesilate (1) · Cord Blood Stem Cell Transplantation (1) · Cyclophosphamide (1)
CorrectSequence Therapeutics Co., Ltd (3) · Medical Research Council (3) · Zhejiang University (3) · Baylor College of Medicine (2) · Children's Hospital Medical Center, Cincinnati (2) · Children's Hospital of Fudan University (2) · Emory University (2) · National Heart, Lung, and Blood Institute (NHLBI) (2) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2) · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (2) · Agnes LePort (1) · Allife Medical Science and Technology Co., Ltd. (1) · Anjali Sharathkumar (1) · Cairo University (1) · Cajal Therapeutics Inc. (1)
China (17) · United States (17) · Australia (2) · United Kingdom (2) · Bangladesh (1) · Egypt (1) · Greece (1) · Senegal (1) · The Gambia (1) · Uganda (1)
Yongrong Lai, M.D. (3) · John F Tisdale, M.D. (2) · Jonathan Powell, PhD (2) · Xiaowen Zhai, M.D. (2) · Aarthy Joseph, Dr (1) · Ahmed M Sayed, professor (1) · Alex George, MD, PhD (1) · Amina Khambalia, MSc (1) · Anjali A. Sharathkumar, MBBS, MD, MS (1) · Ann Haight, M.D. (1) · Arthur L Burnett, MD, MBA (1) · Athanasios Z Jamurtas, PhD (1) · B. Douglas Smith, MD (1) · Bhupesh Panwar, MD (1) · Brady Stein, MD (1)
PMID 42705233, PMID 19793860, PMID 19819109, PMID 22094494, PMID 24034070, PMID 24899360, PMID 28245227, PMID 29426300, PMID 29616857, PMID 32611669, PMID 35576529, PMID 38181784, PMID 39172743, PMID 39265169, PMID 40222814, PMID 40441700, PMID 41809202, PMID 41951736, PMID 42376265
P30CA006973 (1), P30CA060553 (1), R01HL147879 (1)