5 completed, 2 unknown, 1 active not recruiting, 1 suspended. 4 Phase 2, 2 Phase 1, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Completed 4 |
| Phase 1 | 2 | Terminated 1, Unknown 1 |
| Early Phase 1 | 1 | Unknown 1 |
Follow Amyotrophic lateral sclerosis 1: new trials by email Literature Review of Amyotrophic lateral sclerosis 1 trials Research Report on Amyotrophic lateral sclerosis 1
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of VRG50635 in Participants With Amyotrophic Lateral Sclerosis (ALS) VRG50635 - Amyotrophic Lateral Sclerosis | Phase 1 | Terminated | Verge Genomics | 54 | 2024-01-15 | 2025-12-15 |
| ALS Diagnosis From a Saliva Sample: a Non-coding RNA Analysis Approach Saliva sample - Amyotrophic Lateral Sclerosis, Sporadic, Amyotrophic Lateral Sclerosis | Active not recruiting | ZIWIG | 653 | 2023-07-11 | 2026-03-27 | |
| A Study to Evaluate, Safety, Tolerability, and PK of AP-101 in Participants With ALS AP-101, Placebo - Amyotrophic Lateral Sclerosis | Phase 2 | Completed | AL-S Pharma | 73 | 2021-09-02 | 2026-09-30 |
| A Study to Evaluate AP-101 in Familial and Sporadic Amyotrophic Lateral Sclerosis (ALS) AP-101 - Amyotrophic Lateral Sclerosis | Phase 1 | Unknown | AL-S Pharma | 18 | 2019-10-10 | 2020-10-27 |
| Bioenergetics and Protein Metabolism in Sporadic Amyotrophic Lateral Sclerosis Skin Biopsy - Sporadic Amyotrophic Lateral Sclerosis | Early Phase 1 | Unknown | University Hospital, Angers | 30 | 2016-11-01 | 2016-11-23 |
| Mexiletine in Sporadic Amyotrophic Lateral Sclerosis Mexiletine, Placebo - Sporadic Amyotrophic Lateral Sclerosis | Phase 2 | Completed | University of Washington | 20 | 2016-10-01 | 2019-12-05 |
| Dual Treatment With Lithium and Valproate in ALS. Active treatment with dual therapy, Placebos - Amyotrophic Lateral Sclerosis, Amyotrophic Lateral Sclerosis, Sporadic | Phase 2 | Completed | El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez | 43 | 2016-05-01 | 2020-08-10 |
| Understanding Clinical Phenotype and Collecting Biomarker Samples in C9ORF72 ALS C9ORF72 Amyotrophic Lateral Sclerosis (ALS) | Completed | Washington University School of Medicine | 128 | 2015-02-01 | 2021-07-08 | |
| Mexiletine in Sporadic Amyotrophic Lateral Sclerosis (SALS) Mexiletine, Placebo - Sporadic Amyotrophic Lateral Sclerosis | Phase 2 | Completed | University of Washington | 75 | 2013-07-01 | 2021-09-29 |
| SOD1 Kinetics Measurements in ALS Patients Amyotrophic Lateral Sclerosis, Familial, Amyotrophic Lateral Sclerosis, Sporadic | Suspended | Washington University School of Medicine | 86 | 2012-12-01 | 2024-07-25 | |
| Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular Disorders Amyotrophic Lateral Sclerosis, Frontotemporal Dementia | Withdrawn | University of Massachusetts, Worcester | 2009-01-01 | 2024-09-19 |
Amyotrophic Lateral Sclerosis (8) · Frontotemporal Dementia (1) · Frontotemporal Dementia With Motor Neuron Disease (1) · Miyoshi myopathy (1) · Motor Neuron Disease (1) · Muscular Dystrophies (1)
Central Nervous System Diseases (8) · Metabolic Diseases (8) · Nervous System Diseases (8) · Neurodegenerative Diseases (8) · Neuromuscular Diseases (8) · Nutritional and Metabolic Diseases (8) · Proteostasis Deficiencies (8) · Spinal Cord Diseases (8) · TDP-43 Proteinopathies (8) · Motor Neuron Disease (7) · Brain Diseases (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Dementia (1) · Frontotemporal Lobar Degeneration (1) · Genetic Diseases, Inborn (1)
Mexiletine (2)
AL-S Pharma (2) · University of Washington (2) · Washington University School of Medicine (2) · El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez (1) · University Hospital, Angers (1) · University of Massachusetts, Worcester (1) · Verge Genomics (1) · ZIWIG (1)
United States (6) · Canada (3) · Belgium (2) · Netherlands (2) · Finland (1) · France (1) · Germany (1) · Mexico (1) · South Korea (1) · Sweden (1)
Diego Cadavid, MD (1) · Michael D Weiss, MD (1) · Michael Weiss, MD (1) · Robert H Brown Jr., D Phil,MD (1) · Timothy M Miller, MD, PhD (1)
PMID 19251627, PMID 19734901, PMID 20582942, PMID 20685689, PMID 20801717, PMID 21438137, PMID 22801503, PMID 23152587, PMID 37119480
2023 (1)