19 completed, 5 active not recruiting, 3 terminated, 2 recruiting. 15 Phase 1, 9 Phase 2, 4 Phase 4, 1 Early Phase 1, 1 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effectiveness of Nontraditional Hydroxyurea Algorithms: Novel and Clinical Evaluations (ENHANCE) PK-optimized oral hydroxyurea at MTD until 15 years of age. - Sickle Cell Anemia (HbSS), Sickle-β0-thalassemia (HbSβ0) | Phase 4 | Recruiting | Children's Hospital Medical Center, Cincinnati | 50 | 2024-12-19 | 2025-09-16 |
| Pharmacokinetic Study in the Biliary Complications During Liver Transplantation Pharmacokinetic - Liver Transplantation | Unknown | University Hospital, Grenoble | 10 | 2024-09-15 | 2024-09-19 | |
| sEphB4-HSA in Treating Participants With BCG-Unresponsive or Refractory Bladder Cancer Pharmacokinetic Study, Recombinant EphB4-HSA Fusion Protein - Recurrent Bladder Carcinoma, Bladder Cancer Stage 0 | Phase 1 | Withdrawn | University of Southern California | 2023-08-01 | 2023-06-26 | |
| Testing the Safety of the Anti-cancer Drugs Tazemetostat and Belinostat in Patients With Lymphomas That Have Resisted Treatment Belinostat, Biopsy Procedure, Biospecimen Collection - Recurrent B-Cell Non-Hodgkin Lymphoma, Recurrent Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 48 | 2023-03-01 | 2026-09-18 |
| 64 Cu-DOTA-alendronate PET Imaging in Localizing and Characterizing Breast Calcifications in Participants Before Undergoing Mastectomy Computed Tomography, Copper Cu-64-DOTA-alendronate, Pharmacokinetic Study - Breast Carcinoma, Calcification | Early Phase 1 | Completed | City of Hope Medical Center | 1 | 2021-11-03 | 2024-06-24 |
| Candidate Gene Association Study With Injury in Elite Male Youth Football Players Genetic variants - Injuries, Genetic Change | Completed | St Mary's University College | 123 | 2019-12-01 | 2021-07-07 | |
| Olaparib and High-Dose Chemotherapy in Treating Patients With Relapsed or Refractory Lymphomas Undergoing Stem Cell Transplant Busulfan, Gemcitabine, Melphalan - Recurrent Diffuse Large B-Cell Lymphoma, Recurrent T-Cell Non-Hodgkin Lymphoma | Phase 1 | Completed | M.D. Anderson Cancer Center | 50 | 2019-09-13 | 2026-07-30 |
| TAK-659 and Paclitaxel in Treating Patients With Advanced Solid Tumors Mivavotinib, Paclitaxel, Pharmacokinetic Study - Advanced Malignant Solid Neoplasm, Ovarian Carcinoma | Phase 1 | Completed | M.D. Anderson Cancer Center | 52 | 2019-03-05 | 2023-02-28 |
| Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial) Pharmacokinetic Study, Ulixertinib - Advanced Malignant Solid Neoplasm, Recurrent Ependymal Tumor | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 20 | 2018-11-14 | 2026-09-21 |
| JNJ-40346527 in Treating Participants With Relapsed or Refractory Acute Myeloid Leukemia Edicotinib, Pharmacokinetic Study - Recurrent Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia | Phase 2 | Terminated | OHSU Knight Cancer Institute | 3 | 2018-10-05 | 2021-12-02 |
| Nivolumab With or Without Ipilimumab in Treating Patients With Recurrent or High Grade Gynecologic Cancer With Metastatic Peritoneal Carcinomatosis Ipilimumab, Laboratory Biomarker Analysis, Nivolumab - Malignant Peritoneal Neoplasm, Malignant Retroperitoneal Neoplasm | Phase 1 | Completed | M.D. Anderson Cancer Center | 26 | 2018-09-21 | 2025-05-22 |
| Regorafenib and Methotrexate in Treating Participants With Recurrent or Metastatic KRAS Mutated Non-Small Cell Lung Cancer Methotrexate, Pharmacokinetic Study, Regorafenib - KRAS Gene Mutation, Metastatic Malignant Neoplasm in the Brain | Phase 2 | Completed | Stanford University | 22 | 2018-08-14 | 2023-08-01 |
| Ibrutinib and Ixazomib Citrate in Treating Newly Diagnosed, Relapsed or Refractory Waldenstrom Macroglobulinemia Ibrutinib, Ixazomib Citrate, Laboratory Biomarker Analysis - Recurrent Waldenstrom Macroglobulinemia, Refractory Waldenstrom Macroglobulinemia | Phase 2 | Terminated | Mayo Clinic | 21 | 2018-08-14 | 2026-05-05 |
| Panitumumab-IRDye800 in Detecting Cancer in Participants With Lung Cancer During Surgery Near-Infrared Fluorescence Imaging, Panitumumab-IRDye800, Pharmacokinetic Study - Lung Carcinoma, Metastatic Malignant Neoplasm in the Lung | Phase 1 / Phase 2 | Recruiting | Stanford University | 30 | 2018-07-19 | 2026-10-05 |
| Mirvetuximab Soravtansine and Rucaparib Camsylate in Treating Participants With Recurrent Endometrial, Ovarian, Fallopian Tube or Primary Peritoneal Cancer Laboratory Biomarker Analysis, Mirvetuximab Soravtansine, Pharmacokinetic Study - BRCA1 Gene Mutation, BRCA2 Gene Mutation | Phase 1 | Completed | Ohio State University Comprehensive Cancer Center | 25 | 2018-07-12 | 2025-02-13 |
| Pharmacokinetic and Pharmacodynamic Modelling of Norepinephrine in Patients Under Target Controlled Infusions (TCI) for Anaesthesia Pharmacokinetic - Neurosurgery, Intervention | Completed | Assistance Publique - Hôpitaux de Paris | 26 | 2018-06-27 | 2023-09-14 | |
| Ribociclib and Aromatase Inhibitor in Treating Older Participants With Hormone Receptor Positive Metastatic Breast Cancer Aromatase Inhibitor, Laboratory Biomarker Analysis, Pharmacokinetic Study - Estrogen Receptor and/or Progesterone Receptor Positive, HER2/Neu Negative | Phase 2 | Completed | City of Hope Medical Center | 2 | 2018-06-14 | 2024-02-20 |
| FID-007 in Treating Participants With Advanced Solid Tumors Laboratory Biomarker Analysis, PEOX-based Polymer Encapsulated Paclitaxel FID-007, Pharmacokinetic Study - Advanced Malignant Solid Neoplasm, Refractory Malignant Solid Neoplasm | Phase 1 | Active not recruiting | University of Southern California | 50 | 2018-05-25 | 2026-04-29 |
| BCMA-Specific CAR T-Cells Combined With a Gamma Secretase Inhibitor (JSMD194) to Treat Relapsed or Persistent Multiple Myeloma BCMA-specific CAR-expressing T Lymphocytes, Cyclophosphamide, Fludarabine - Recurrent Plasma Cell Myeloma, Refractory Plasma Cell Myeloma | Phase 1 | Terminated | Fred Hutchinson Cancer Center | 19 | 2018-05-23 | 2024-01-08 |
| Pevonedistat and Ibrutinib in Treating Participants With Relapsed or Refractory CLL or Non-Hodgkin Lymphoma Ibrutinib, Laboratory Biomarker Analysis, Pevonedistat - B-Cell Prolymphocytic Leukemia, Recurrent Chronic Lymphocytic Leukemia | Phase 1 | Active not recruiting | City of Hope Medical Center | 18 | 2018-04-27 | 2026-04-27 |
Showing 20 of 32. Sign in to see all of them.
Lymphoma, Non-Hodgkin (3) · Ovarian Neoplasms (3) · Carcinoma, Non-Small-Cell Lung (2) · Endometrial Neoplasms (2) · Fallopian Tube Neoplasms (2) · Glioma (2) · Hodgkin Disease (2) · Lung Neoplasms (2) · Lymphoma, Follicular (2) · Lymphoma, Large B-Cell, Diffuse (2) · Lymphoma, T-Cell (2) · Adrenal Cortex Neoplasms (1) · Anemia, Sickle Cell (1) · Brain Neoplasms (1) · Breast Neoplasms (1)
M.D. Anderson Cancer Center (6) · City of Hope Medical Center (4) · Assistance Publique - Hôpitaux de Paris (3) · National Cancer Institute (NCI) (3) · Stanford University (2) · University Hospital, Toulouse (2) · University of Southern California (2) · Centre Oscar Lambret (1) · Centro Internacional de Entrenamiento e Investigaciones Médicas (1) · Children's Hospital Medical Center, Cincinnati (1) · Fred Hutchinson Cancer Center (1) · Mayo Clinic (1) · OHSU Knight Cancer Institute (1) · Ohio State University Comprehensive Cancer Center (1) · St Mary's University College (1)
United States (23) · France (7) · Colombia (1) · Puerto Rico (1) · United Kingdom (1)
Alex F Herrera (1) · Alexey Danilov (1) · Amir A Jazaeri (1) · Andrew Cowan (1) · Anthony El-Khoueiry, MD (1) · Asher A. Chanan-Khan, M.D. (1) · Britt K Erickson (1) · Charles T. Quinn, Professor of Pediatrics, M.D., M.S. (1) · Elie Traer, MD (1) · Ferdinandos Skoulidis, MD,PHD (1) · Floor Backes, MD (1) · Heather Wakelee (1)
PMID 27956421, PMID 28379954, PMID 31401903, PMID 31558469, PMID 36510685, PMID 36631449, PMID 36658425, PMID 37414012, PMID 37974084, PMID 38471508, PMID 38608694, PMID 38935895
P30CA014089 (2), P30CA016672 (2), 2009 (1), N01CN00033 (1), P30CA014520 (1), P30CA069533 (1), R01CA155196 (1), U10CA180886 (1), UM1CA186689 (1)