37 completed, 6 terminated, 5 unknown, 2 active not recruiting. 31 Phase 2, 15 Phase 1, 11 Not applicable, 1 Phase 3.
Follow Adult Acute Lymphoblastic Leukemia in Remission: new trials by email Literature Review of Adult Acute Lymphoblastic Leukemia in Remission trials Research Report on Adult Acute Lymphoblastic Leukemia in Remission
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD22 anti-CD19/22-CAR vector-transduced T cells - Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Unknown | Chinese PLA General Hospital | 30 | 2017-08-01 | 2019-04-17 |
| Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD20 anti-CD19/20-CAR vector-transduced T cells - Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Completed | Chinese PLA General Hospital | 100 | 2017-04-01 | 2020-09-02 |
| Anti-CD19 CAR T Infusion Combined With Allogeneic Stem Cell Transplantation for B-cell Leukemia/Lymphoma anti-CD19 CAR-T, Fludarabine, Cyclophosphamide - B-cell Adult Acute Lymphoblastic Leukemia, B-cell Chronic Lymphocytic Leukemia | Phase 1 | Unknown | First Affiliated Hospital of Wenzhou Medical University | 20 | 2016-10-01 | 2019-11-27 |
| Competitive Transfer of αCD19-TCRz-CD28 and αCD19-TCRz-CD137 CAR-T Cells for B-cell Leukemia/Lymphoma anti-CD19 CAR-T, Fludarabine, Cyclophosphamide - Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Unknown | The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine | 20 | 2016-02-01 | 2017-03-16 |
| Organ-Sparing Marrow-Targeted Irradiation Before Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies radiation therapy, cyclophosphamide, anti-thymocyte globulin - Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission | Phase 1 | Completed | Sumithira Vasu | 33 | 2015-07-27 | 2023-09-21 |
| Vaccine Therapy in Reducing the Frequency of Cytomegalovirus Events in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant CMVpp65-A*0201 peptide vaccine, Placebo, Laboratory Biomarker Analysis - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | City of Hope Medical Center | 61 | 2015-05-21 | 2025-03-03 |
| Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts in Preventing GVHD in Children Allogeneic Hematopoietic Stem Cell Transplantation, Fludarabine Phosphate, Laboratory Biomarker Analysis - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 20 | 2014-04-10 | 2024-03-12 |
| Clofarabine and Melphalan Before Donor Stem Cell Transplant in Treating Patients With Myelodysplasia, Acute Leukemia in Remission, or Chronic Myelomonocytic Leukemia clofarabine, melphalan, allogeneic hematopoietic stem cell transplantation - Adult Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Phase 2 | Active not recruiting | City of Hope Medical Center | 72 | 2014-02-10 | 2026-08-27 |
| Single or Double Donor Umbilical Cord Blood Transplant in Treating Patients With High-Risk Hematologic Malignancies cyclophosphamide, fludarabine phosphate, mycophenolate mofetil - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 2 | Withdrawn | University of Medicine and Dentistry of New Jersey | 2014-01-01 | 2016-07-14 | |
| Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by CART19 anti-CD19-CAR vector-transduced T cells - Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Unknown | Chinese PLA General Hospital | 12 | 2013-04-01 | 2016-01-28 |
| Genetically Engineered Lymphocyte Therapy in Treating Patients With Lymphoma That is Resistant or Refractory to Chemotherapy anti-CD20-CAR vector-transduced autologous T cells, genetically engineered lymphocyte therapy - Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Unknown | Chinese PLA General Hospital | 50 | 2013-01-01 | 2015-09-29 |
| Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell Transplant tetanus-CMV fusion peptide vaccine, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 | Completed | City of Hope Medical Center | 36 | 2012-10-29 | 2024-04-02 |
| Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem Cell Transplant management of therapy complications, musculoskeletal complications management/prevention - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Withdrawn | Roswell Park Cancer Institute | 2012-05-01 | 2012-07-09 | |
| Safety and Efficacy of POL6326 for Mobilization/Transplant of Sibling Donor in Patients With Hematologic Malignancies POL6326, Leukapheresis, PBSC Transplant - Acute Myeloid Leukemia in Remission, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Completed | Polyphor Ltd. | 38 | 2012-04-01 | 2016-02-26 |
| Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies fludarabine phosphate, melphalan, total-body irradiation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Roswell Park Cancer Institute | 94 | 2012-02-28 | 2019-09-24 |
| Etoposide, Filgrastim, and Plerixafor in Improving Stem Cell Mobilization in Treating Patients With Non-Hodgkin Lymphoma plerixafor, filgrastim, etoposide - Adult Acute Lymphoblastic Leukemia in Remission, Adult Grade III Lymphomatoid Granulomatosis | Not applicable | Terminated | Case Comprehensive Cancer Center | 25 | 2011-10-01 | 2019-06-14 |
| Cyclophosphamide for Prevention of Graft-Versus-Host Disease After Allogeneic Peripheral Blood Stem Cell Transplantation in Patients With Hematological Malignancies cyclophosphamide, cyclosporine, peripheral blood stem cell transplantation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Fred Hutchinson Cancer Center | 43 | 2011-09-01 | 2017-05-19 |
| A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies Fludarabine, Busulfan, Total Body Irradiation (TBI) - Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 40 | 2011-08-04 | 2026-04-15 |
| Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant infection prophylaxis and management, laboratory biomarker analysis, flow cytometry - Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia | Active not recruiting | City of Hope Medical Center | 153 | 2011-01-11 | 2026-10-22 | |
| Deferasirox in Treating Iron Overload Caused By Blood Transfusions in Patients With Hematologic Malignancies deferasirox, laboratory biomarker analysis, enzyme-linked immunosorbent assay - Acute Undifferentiated Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Wake Forest University Health Sciences | 16 | 2011-01-01 | 2018-09-07 |
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Leukemia, Lymphocytic, Chronic, B-Cell (42) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (41) · Lymphoma, Follicular (38) · Lymphoma, Large B-Cell, Diffuse (36) · Lymphoma, Mantle-Cell (36) · Lymphoma, Non-Hodgkin (33) · Leukemia, Myeloid, Acute (32) · Lymphoma, B-Cell, Marginal Zone (32) · Burkitt Lymphoma (30) · Congenital Abnormalities (30) · Hodgkin Disease (30) · Lymphoma, T-Cell, Cutaneous (30) · Leukemia, Myeloid, Accelerated Phase (29) · Lymphoma, Large-Cell, Immunoblastic (29) · Multiple Myeloma (28)
Hematologic Diseases (51) · Hemic and Lymphatic Diseases (51) · Neoplasms (51) · Neoplasms by Histologic Type (51) · Leukemia (50) · Chronic Disease (49) · Disease Attributes (49) · Immune System Diseases (49) · Immunoproliferative Disorders (49) · Leukemia, Lymphoid (49) · Lymphatic Diseases (49) · Lymphoproliferative Disorders (49) · Pathologic Processes (49) · Pathological Conditions, Signs and Symptoms (49) · Leukemia, B-Cell (42)
Whole-Body Irradiation (21) · fludarabine phosphate (20) · Peripheral Blood Stem Cell Transplantation (18) · Mycophenolic Acid (17) · Cyclophosphamide (14) · Tacrolimus (14) · Cyclosporine (11) · Methotrexate (7) · Transplantation (7) · merphos (7) · Busulfan (6) · Therapeutics (5) · Antilymphocyte Serum (4) · Melphalan (4) · thymoglobulin (4)
Fred Hutchinson Cancer Center (19) · City of Hope Medical Center (5) · National Cancer Institute (NCI) (5) · Chinese PLA General Hospital (4) · Roswell Park Cancer Institute (4) · Case Comprehensive Cancer Center (3) · Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium (2) · First Affiliated Hospital of Wenzhou Medical University (1) · Martin, Paul (1) · Polyphor Ltd. (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1) · Sumithira Vasu (1) · The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine (1) · University of Medicine and Dentistry of New Jersey (1) · University of Nebraska (1)
United States (45) · China (6) · Germany (4) · Italy (4) · Denmark (1)
Brenda Sandmaier (4) · Paul Martin (3) · David Maloney (2) · George Chen (2) · George Georges (2) · Philip McCarthy (2) · Ryotaro Nakamura (2) · Ann Woolfrey (1) · B. Smith (1) · Boglarka Gyurkocza (1) · Brenda Cooper, MD (1) · Colleen Delaney (1) · Daniel Couriel, M.D. (1) · Hillard Lazarus (1) · John Deeken (1)
PMID 32499241, PMID 34515338, PMID 10204198, PMID 18698002, PMID 21508120, PMID 22259028, PMID 24077846, PMID 24474568, PMID 25085357, PMID 25317870, PMID 25444722, PMID 26451310, PMID 26764356, PMID 26853648, PMID 28817727, PMID 29263894, PMID 29599530, PMID 30562587, PMID 31076448, PMID 31815579, PMID 32245502, PMID 32628342, PMID 33420905, PMID 34162404, PMID 34935483, PMID 35007144, PMID 36282798, PMID 37939122, PMID 41804087
P30CA015704 (10), P01CA018029 (8), P01CA078902 (2), K23CA154532 (1), N01CM62202 (1), P01CA044991 (1), P01HL036444 (1), P30CA016056 (1), P30CA036727 (1), P30CA043703 (1), P30CA072720 (1), R01CA112631 (1), R01CA181045 (1), R01HL121568 (1), R24HL074445 (1)