8 completed, 3 terminated. 5 Phase 1, 5 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 5 | Completed 5 |
| Phase 2 | 5 | Completed 4, Terminated 1 |
| Phase 3 | 2 | Terminated 2 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pivotal Study in Nosocomial Pneumonia Suspected or Confirmed to be Due to Pseudomonas Murepavadin, One anti-pseudomonal antibiotic - Pneumonia | Phase 3 | Terminated | Polyphor Ltd. | 2 | 2018-10-22 | 2019-08-28 |
| Pivotal Study in VAP Suspected or Confirmed to be Due to Pseudomonas Aeruginosa Murepavadin, Two anti-pseudomonal antibiotics - Pneumonia | Phase 3 | Terminated | Polyphor Ltd. | 41 | 2018-03-23 | 2019-08-28 |
| DDI Study to Investigate Interaction Between Amikacin and POL7080 POL7080, Amikacin, POL7080 + Amikacin - Healthy | Phase 1 | Completed | Polyphor Ltd. | 14 | 2016-04-01 | 2017-02-01 |
| Safety, Efficacy and PK/PD of POL7080 in Patients With Exacerbation of Non-cystic Fibrosis Bronchiectasis. POL7080 - Bronchiectasis, Lower Respiratory Infection | Phase 2 | Terminated | Polyphor Ltd. | 20 | 2013-12-01 | 2017-02-01 |
| Pharmacokinetics, Safety and Efficacy of POL7080 in Patients With Ventilator Associated Pseudomonas Aeruginosa Pneumonia POL7080 - Ventilator Associated Pneumonia, Lower Respiratory Infection | Phase 2 | Completed | Polyphor Ltd. | 25 | 2013-10-01 | 2017-11-28 |
| CXCR4 Antagonism for Cell Mobilisation and Healing in Acute Myocardial Infarction (CATCH-AMI) POL6326, Placebo - Large Reperfused ST-Elevation Myocardial Infarction | Phase 2 | Completed | Polyphor Ltd. | 120 | 2013-07-01 | 2016-06-10 |
| Dose Escalation of POL6326 in Combination With Eribulin in Patients With Metastatic Breast Cancer POL6326 - Metastatic Breast Cancer | Phase 1 | Completed | Polyphor Ltd. | 54 | 2013-06-01 | 2018-09-14 |
| Pharmacokinetics and Safety of POL7080 in Patients With Renal Impairment POL7080 - Renal Impairment | Phase 1 | Completed | Polyphor Ltd. | 48 | 2013-04-01 | 2016-06-17 |
| Safety and Efficacy of POL6326 for Mobilization/Transplant of Sibling Donor in Patients With Hematologic Malignancies POL6326, Leukapheresis, PBSC Transplant - Acute Myeloid Leukemia in Remission, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Completed | Polyphor Ltd. | 38 | 2012-04-01 | 2016-02-26 |
| Safety and Efficacy of POL6326 for Mobilization of Hematopoietic Stem Cells in Healthy Volunteers POL6326 - Healthy | Phase 1 | Completed | Polyphor Ltd. | 27 | 2012-02-01 | 2015-11-25 |
| Exploratory Study on POL6326 in Stem Cell Mobilization POL6326 - Multiple Myeloma | Phase 2 | Completed | Polyphor Ltd. | 21 | 2009-04-01 | 2014-04-23 |
Multiple Myeloma (2) · Pneumonia (2) · Pseudomonas Infections (2) · Breast Neoplasms (1) · Bronchiectasis (1) · Healthcare-Associated Pneumonia (1) · Hodgkin Disease (1) · Leukemia, Lymphocytic, Chronic, B-Cell (1) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (1) · Lymphoma, Non-Hodgkin (1) · Myelodysplastic Syndromes (1) · Myeloproliferative Disorders (1) · Pneumonia, Ventilator-Associated (1) · Renal Insufficiency (1) · ST Elevation Myocardial Infarction (1)
murepavadin (6) · balixafortide (5) · Amikacin (1) · Leukapheresis (1)
Germany (5) · Spain (4) · United States (4) · France (2) · Greece (2) · Hungary (2) · Israel (2) · United Kingdom (2) · Austria (1) · Brazil (1) · Croatia (1) · Czechia (1) · Estonia (1) · Mexico (1) · Poland (1)
Adam Hill, MD PhD (1) · Antoni Torres, MD PhD (1) · Atef Halabi, MD (1) · Daniel Couriel, M.D. (1) · Eva Polverino, MD (1) · Evangelos Giamarellos-Bourboulis, MD PhD (1) · Halvard Boenig, M.D. Ph.D (1) · Hartmut Goldschmidt, MD (1) · Kai C. Wollert, MD (1)