169 completed. 169 Phase 2, 25 Phase 1, 10 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 169 | Completed 169 |
| Phase 1 | 25 | Completed 25 |
| Phase 3 | 10 | Completed 10 |
Follow Adenoma: new trials by email Literature Review of Adenoma trials Research Report on Adenoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Trial of Nab-sirolimus in Patients With Well-differentiated Neuroendocrine Tumors (NETs) of the Gastrointestinal Tract, Lung, or Pancreas Who Have Not Received Prior Treatment With mTOR Inhibitors nab-sirolimus - Neuroendocrine Tumors, NET | Phase 2 | Completed | Aadi Bioscience, Inc. | 12 | 2023-10-20 | 2026-08-25 |
| Switch-Maintenance Gemcitabine After First-Line Chemotherapy In Patients With Malignant Pleural Mesothelioma Gemcitabine, supportive care - Malignant Pleural Mesothelioma | Phase 2 | Completed | Ain Shams University | 40 | 2023-04-01 | 2024-08-27 |
| A Safety and Efficacy Study Evaluating CTX131 in Adult Subjects With Relapsed or Refractory Solid Tumors CTX131 - Clear Cell Renal Cell Carcinoma, Cervical Carcinoma | Phase 1 / Phase 2 | Completed | CRISPR Therapeutics AG | 19 | 2023-03-13 | 2025-11-26 |
| Niraparib Efficacy in Patient With Unresectable Mesothelioma Niraparib Oral Product, Active Symptom Control - Mesothelioma, Malignant | Phase 2 | Completed | University Hospital Southampton NHS Foundation Trust | 88 | 2022-07-11 | 2025-05-15 |
| The CHAMP-study: The CHemopreventive Effect of Lithium in Familial AdenoMatous Polyposis Lithium Carbonate - Familial Adenomatous Polyposis | Phase 2 | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 12 | 2022-06-02 | 2024-10-04 |
| A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations ENV-101 (taladegib) - Solid Tumors With PTCH1 Loss-of-function Mutations | Phase 2 | Completed | Endeavor Biomedicines, Inc. | 20 | 2022-05-24 | 2026-03-05 |
| ......SMARTEST Trial...... Cyclophosphamide, Tremelimumab, Durvalumab - Mesothelioma, Malignant | Phase 2 | Completed | University Health Network, Toronto | 30 | 2022-05-03 | 2025-12-29 |
| Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including Mesothelioma RSO-021 - Malignant Pleural Effusion, Malignant Pleural Mesothelioma | Phase 1 / Phase 2 | Completed | RS Oncology LLC | 50 | 2022-03-31 | 2026-07-24 |
| A Study to Evaluate Nivolumab in Combination With Ipilimumab Versus Pemetrexed With Cisplatin or Carboplatin for Unresectable Pleural Mesothelioma in Chinese Participants Nivolumab, Ipilimumab, Pemetrexed - Mesothelioma, Malignant | Phase 2 | Completed | Bristol-Myers Squibb | 102 | 2022-01-25 | 2026-01-23 |
| A Study of Immunotherapy Drugs Nivolumab and Ipilimumab in Patients w/Resectable Malignant Peritoneal Mesothelioma Nivolumab, Ipilimumab - Mesothelioma, Peritoneal Mesothelioma | Phase 2 | Completed | University of Chicago | 2 | 2021-12-01 | 2024-01-03 |
| Study of the Efficacy and Safety of the Bintrafusp Alfa in Previously Treated Advanced Malignant Pleural Mesothelioma Bintrafusp alfa - Mesothelioma; Lung | Phase 2 | Completed | Fundación GECP | 47 | 2021-09-20 | 2025-12-23 |
| Oral Cryotherapy Plus Acupressure and Acupuncture Versus Oral Cryotherapy for Decreasing Chemotherapy-Induced Peripheral Neuropathy From Oxaliplatin-Based Chemotherapy in Patients With Gastrointestinal Cancer Acupuncture Therapy, Acupressure Therapy, Oral Cryotherapy - Appendix Carcinoma, Colon Carcinoma | Phase 2 | Completed | University of Washington | 78 | 2021-06-01 | 2026-01-21 |
| SAKK 17/18 (ORIGIN) MPM & NSCLC >1st Line Gemci & Atezo Ph II Gemcitabine, Atezolizumab - Malignant Pleural Mesothelioma, Non-small Cell Lung Cancer | Phase 2 | Completed | Swiss Cancer Institute | 68 | 2021-03-17 | 2024-07-01 |
| Trial of eRapa to Prevent Progression in Familial Adenomatous Polyposis Patients Under Active Surveillance Encapsulated Rapamycin (eRapa) - Familial Adenomatous Polyposis | Phase 2 | Completed | Rapamycin Holdings Inc. | 30 | 2021-01-18 | 2026-10-22 |
| Feasibility of the LUM Imaging System for Peritoneal Surface Malignancies LUM Imaging System - Peritoneal Metastases | Phase 1 / Phase 2 | Completed | Lumicell, Inc. | 18 | 2019-03-18 | 2026-01-16 |
| Nivolumab With Chemotherapy in Pleural Mesothelioma After Surgery Carboplatin AUC 5, Cisplatin 75 mg/m2, Pemetrexed 500 mg/m2 - Pleural Mesothelioma Malignant | Phase 2 | Completed | Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest | 92 | 2019-02-04 | 2025-02-06 |
| Mesothelioma Stratified Therapy (MiST) : A Multi-drug Phase II Trial in Malignant Mesothelioma Rucaparib, Abemaciclib, pembrolizumab & bemcentinib - Mesothelioma, Malignant | Phase 2 | Completed | University of Leicester | 186 | 2019-01-28 | 2026-08-17 |
| Diadem to Investigate the Activity and Safety of Durvalumab Durvalumab - Pleura Mesothelioma | Phase 2 | Completed | Mario Negri Institute for Pharmacological Research | 57 | 2018-10-17 | 2023-03-15 |
| A Trial of Niraparib in BAP1 and Other DNA Damage Response (DDR) Deficient Neoplasms (UF-STO-ETI-001) Niraparib - Mesothelioma, Uveal Melanoma | Phase 2 | Completed | University of Florida | 37 | 2018-08-13 | 2023-09-15 |
| Olaparib in People With Malignant Mesothelioma Olaparib, ClinOmics - Mesothelioma | Phase 2 | Completed | National Cancer Institute (NCI) | 23 | 2018-07-11 | 2021-04-09 |
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Mesothelioma, Malignant (82) · Mesothelioma (50) · Adenoma, Islet Cell (19) · Solitary Fibrous Tumor, Pleural (18) · Insulinoma (13) · Glucagonoma (12) · Somatostatinoma (12) · Adenomatous Polyposis Coli (11) · Carcinoma, Islet Cell (11) · Carcinoma, Non-Small-Cell Lung (11) · Colorectal Neoplasms (11) · Gastrinoma (11) · Adenomatous Polyps (9) · Neoplasms (9) · Carcinoma, Renal Cell (8)
Neoplasms by Histologic Type (169) · Neoplasms, Glandular and Epithelial (169) · Neoplasms (160) · Neoplasms by Site (148) · Neoplasms, Mesothelial (116) · Respiratory Tract Diseases (94) · Respiratory Tract Neoplasms (94) · Thoracic Neoplasms (94) · Lung Diseases (93) · Lung Neoplasms (86) · Pleural Neoplasms (82) · Mesothelioma (66) · Digestive System Diseases (57) · Digestive System Neoplasms (57)
Cisplatin (26) · Pemetrexed (22) · Gemcitabine (12) · Nivolumab (8) · Bevacizumab (7) · Carboplatin (6) · Ipilimumab (6) · Erlotinib Hydrochloride (5) · Capecitabine (4) · Chemotherapy, Adjuvant (4) · Cyclophosphamide (4) · Temozolomide (4) · Vinorelbine (4) · durvalumab (4) · Bortezomib (3)
National Cancer Institute (NCI) (25) · Alliance for Clinical Trials in Oncology (5) · Dana-Farber Cancer Institute (5) · Eli Lilly and Company (4) · Memorial Sloan Kettering Cancer Center (4) · Swiss Cancer Institute (4) · European Organisation for Research and Treatment of Cancer - EORTC (3) · H. Lee Moffitt Cancer Center and Research Institute (3) · Novartis Pharmaceuticals (3) · The Netherlands Cancer Institute (3) · University Health Network, Toronto (3) · AGC Biologics S.p.A. (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · Armando Santoro, MD (2) · Columbia University (2)
United States (98) · Italy (20) · Netherlands (15) · United Kingdom (15) · Canada (13) · France (13) · Belgium (11) · Germany (9) · Spain (9) · Switzerland (6) · Australia (4) · Japan (4) · Puerto Rico (3) · Brazil (2) · China (2)
Armando Santoro, MD (3) · Hedy Kindler (3) · Raffit Hassan, M.D. (3) · Antonio Lambiase, MD (2) · Arkadiusz Dudek, MD (2) · Arnaud Scherpereel, MD, PhD (2) · John E. Janik, MD (2) · Linda Garland (2) · Nicholas J West, MB BS FRCS (2) · Paul Baas, MD, PhD (2) · Quincy Chu (2) · Scott Okuno, MD (2) · Timothy Hobday (2) · Abanoub Samir (1)
PMID 31576173, PMID 33358660, PMID 34289971, PMID 37119510, PMID 37279993, PMID 10500494, PMID 11165136, PMID 12565988, PMID 12621133, PMID 14673042, PMID 15084390, PMID 17429100, PMID 17551129, PMID 18006112, PMID 18224661, PMID 18541589, PMID 19258546, PMID 19451433, PMID 19556318, PMID 19652065, PMID 19861511, PMID 19923375, PMID 20056649, PMID 20332274, PMID 20348368, PMID 20406925, PMID 20516268, PMID 20525721, PMID 20530048, PMID 20647340, PMID 21084270, PMID 21684151, PMID 21724580, PMID 21831734, PMID 22149065, PMID 22197613, PMID 22831987, PMID 22964475, PMID 23170065, PMID 23516312, PMID 23791541, PMID 23860535, PMID 23919274, PMID 24014734, PMID 24166893, PMID 24245549, PMID 24445595, PMID 24560453, PMID 24942404, PMID 25070320
U10CA031946 (6), U10CA032102 (4), 2015 (2), 2016 (2), N01CM17102 (2), N01CM62205 (2), N01CN35160 (2), P30CA014599 (2), P30CA015083 (2), P30CA016672 (2), U10CA021115 (2), 2004 (1), 2008 (1), 2014 (1), 2017 (1)