3 terminated. 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 3 | Terminated 3 |
Follow Acidosis, Lactic: new trials by email Literature Review of Acidosis, Lactic trials Research Report on Acidosis, Lactic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Open-label Extension Safety Study of MELAS Patients Who Completed TIS6463-203 (PRIZM) zagociguat 15mg - Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome) | Phase 2 | Terminated | Tisento Therapeutics | 37 | 2025-08-18 | 2026-11-06 |
| Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest Thiamine, placebo - Cardiac Arrest, Shock | Phase 2 | Terminated | Beth Israel Deaconess Medical Center | 41 | 2017-05-01 | 2025-04-10 |
| A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial Disease Cysteamine Bitartrate - Mitochondrial Diseases | Phase 2 | Terminated | Amgen | 22 | 2015-05-19 | 2024-12-27 |
Beriberi (1) · Epilepsies, Myoclonic (1) · Heart Arrest (1) · Leigh Disease (1) · MELAS Syndrome (1) · Mitochondrial Diseases (1) · Mitochondrial Encephalomyopathies (1) · Mitochondrial encephalopathy (1) · Ophthalmoplegia, Chronic Progressive External (1) · Optic Atrophy, Hereditary, Leber (1) · Shock (1) · Visceral myopathy familial external ophthalmoplegia (1)
Acid-Base Imbalance (3) · Acidosis (3) · Metabolic Diseases (3) · Nutritional and Metabolic Diseases (3) · Brain Diseases (2) · Brain Diseases, Metabolic (2) · Brain Diseases, Metabolic, Inborn (2) · Cardiovascular Diseases (2) · Central Nervous System Diseases (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Genetic Diseases, Inborn (2) · Metabolism, Inborn Errors (2) · Mitochondrial Myopathies (2) · Muscular Diseases (2) · Musculoskeletal Diseases (2)
Cysteamine (1) · Saline Solution (1) · Thiamine (1)
Amgen (1) · Beth Israel Deaconess Medical Center (1) · Tisento Therapeutics (1)
United States (3) · Australia (1) · Germany (1) · Italy (1) · United Kingdom (1)
K23HL128814 (1)