37 completed, 7 terminated, 2 active not recruiting, 2 withdrawn. 24 Phase 2, 18 Phase 1, 8 Not applicable, 1 Phase 3.
Follow Accelerated Phase Chronic Myelogenous Leukemia: new trials by email Literature Review of Accelerated Phase Chronic Myelogenous Leukemia trials Research Report on Accelerated Phase Chronic Myelogenous Leukemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Bosutinib in Pediatric Patients With Newly Diagnosed Chronic Phase or Resistant/Intolerant Ph + Chronic Myeloid Leukemia Bosutinib - Philadelphia Chromosome Positive CML, Accelerated Phase Chronic Myelogenous Leukemia | Phase 1 / Phase 2 | Active not recruiting | Children's Oncology Group | 60 | 2020-07-06 | 2026-10-01 |
| CALLS: CML and Ph+ALL Low Level Mutation Prevalence Survey Chronic Phase Chronic Myelogenous Leukemia, Accelerated Phase Chronic Myelogenous Leukemia | Completed | Incyte Biosciences UK | 427 | 2017-12-18 | 2021-08-16 | |
| Single or Double Donor Umbilical Cord Blood Transplant in Treating Patients With High-Risk Hematologic Malignancies cyclophosphamide, fludarabine phosphate, mycophenolate mofetil - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 2 | Withdrawn | University of Medicine and Dentistry of New Jersey | 2014-01-01 | 2016-07-14 | |
| Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies vorinostat, tacrolimus, cyclosporine - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | National Cancer Institute (NCI) | 12 | 2013-06-01 | 2018-07-24 |
| Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies therapeutic allogeneic lymphocytes, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Phase 2 | Completed | University of Chicago | 77 | 2013-04-04 | 2019-08-07 |
| Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell Transplant tetanus-CMV fusion peptide vaccine, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 | Completed | City of Hope Medical Center | 36 | 2012-10-29 | 2024-04-02 |
| Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem Cell Transplant management of therapy complications, musculoskeletal complications management/prevention - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Withdrawn | Roswell Park Cancer Institute | 2012-05-01 | 2012-07-09 | |
| Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies fludarabine phosphate, melphalan, total-body irradiation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Roswell Park Cancer Institute | 94 | 2012-02-28 | 2019-09-24 |
| Dasatinib and Cyclosporine in Treating Patients With Chronic Myelogenous Leukemia Refractory or Intolerant to Imatinib Mesylate dasatinib, diagnostic laboratory biomarker analysis, pharmacological study - Accelerated Phase Chronic Myelogenous Leukemia, Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Phase 1 | Terminated | National Cancer Institute (NCI) | 4 | 2011-09-01 | 2014-04-02 |
| Cyclophosphamide for Prevention of Graft-Versus-Host Disease After Allogeneic Peripheral Blood Stem Cell Transplantation in Patients With Hematological Malignancies cyclophosphamide, cyclosporine, peripheral blood stem cell transplantation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Fred Hutchinson Cancer Center | 43 | 2011-09-01 | 2017-05-19 |
| Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant infection prophylaxis and management, laboratory biomarker analysis, flow cytometry - Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia | Active not recruiting | City of Hope Medical Center | 153 | 2011-01-11 | 2026-10-22 | |
| MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Leukemia Akt inhibitor MK2206, diagnostic laboratory biomarker analysis, pharmacological study - Accelerated Phase Chronic Myelogenous Leukemia, Acute Leukemias of Ambiguous Lineage | Phase 1 | Completed | National Cancer Institute (NCI) | 45 | 2011-01-01 | 2014-04-29 |
| Palifermin in Preventing Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer palifermin, flow cytometry, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Completed | Martin, Paul | 6 | 2010-09-01 | 2014-04-02 |
| Infusion of Off-the-Shelf Expanded Cord Blood Cells to Augment Cord Blood Transplant in Patients With Hematologic Malignancies umbilical cord blood transplantation, fludarabine phosphate, cyclophosphamide - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | Nohla Therapeutics, Inc. | 15 | 2010-08-01 | 2019-03-05 |
| Deferasirox for Treating Patients Who Have Undergone Allogeneic Stem Cell Transplant and Have Iron Overload deferasirox - Iron Overload, Accelerated Phase Chronic Myelogenous Leukemia | Phase 2 | Terminated | City of Hope Medical Center | 1 | 2010-07-01 | 2019-06-18 |
| Plerixafor and Filgrastim For Mobilization of Donor Peripheral Blood Stem Cells Before A Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies plerixafor, filgrastim, peripheral blood stem cell transplantation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Terminated | Fred Hutchinson Cancer Center | 1 | 2010-06-01 | 2017-06-28 |
| Massage Therapy Given by Caregiver in Treating Quality of Life of Young Patients Undergoing Treatment for Cancer massage therapy, questionnaire administration, quality-of-life assessment - Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia | Not applicable | Completed | Wake Forest University Health Sciences | 80 | 2010-04-01 | 2018-07-02 |
| Rituximab in Preventing Acute Graft-Versus-Host Disease in a Donor Stem Cell Transplant for Hematologic Cancer rituximab, mycophenolate mofetil, tacrolimus - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Terminated | University of Nebraska | 20 | 2009-12-10 | 2023-09-06 |
| Sunitinib Malate in Treating HIV-Positive Patients With Cancer Receiving Antiretroviral Therapy sunitinib malate, pharmacological study, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 1 | Completed | National Cancer Institute (NCI) | 42 | 2009-08-01 | 2014-03-17 |
| Treosulfan, Fludarabine Phosphate, and Total-Body Irradiation Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Myelodysplastic Syndrome, Acute Lymphoblastic Leukemia treosulfan, fludarabine phosphate, total-body irradiation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Fred Hutchinson Cancer Center | 96 | 2009-02-01 | 2021-06-22 |
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Leukemia, Myeloid, Accelerated Phase (48) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (37) · Leukemia, Myeloid, Chronic-Phase (36) · Blast Crisis (35) · Congenital Abnormalities (33) · Leukemia, Myeloid, Acute (33) · Leukemia, Lymphocytic, Chronic, B-Cell (29) · Burkitt Lymphoma (28) · Lymphoma, B-Cell, Marginal Zone (27) · Lymphoma, Follicular (27) · Lymphoma, Large B-Cell, Diffuse (27) · Lymphoma, Mantle-Cell (26) · Leukemia, Myelomonocytic, Chronic (25) · Lymphoma, Non-Hodgkin (25) · Lymphoma, T-Cell, Cutaneous (25)
Bone Marrow Diseases (48) · Chronic Disease (48) · Disease Attributes (48) · Hematologic Diseases (48) · Hemic and Lymphatic Diseases (48) · Leukemia, Myeloid (48) · Neoplasms (48) · Neoplasms by Histologic Type (48) · Pathologic Processes (48) · Pathological Conditions, Signs and Symptoms (48) · Leukemia (47) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (39) · Immune System Diseases (37) · Immunoproliferative Disorders (37) · Leukemia, Lymphoid (37)
fludarabine phosphate (15) · Whole-Body Irradiation (12) · Mycophenolic Acid (10) · Peripheral Blood Stem Cell Transplantation (10) · Cyclosporine (9) · Tacrolimus (9) · Cyclophosphamide (7) · Methotrexate (6) · Transplantation (6) · merphos (6) · Busulfan (4) · Imatinib Mesylate (4) · Therapeutics (4) · Antilymphocyte Serum (3) · Cytarabine (3)
National Cancer Institute (NCI) (16) · Fred Hutchinson Cancer Center (15) · City of Hope Medical Center (3) · Roswell Park Cancer Institute (3) · Children's Oncology Group (2) · Case Comprehensive Cancer Center (1) · Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium (1) · Incyte Biosciences UK (1) · Martin, Paul (1) · Nohla Therapeutics, Inc. (1) · University of Chicago (1) · University of Medicine and Dentistry of New Jersey (1) · University of Nebraska (1) · Wake Forest University Health Sciences (1)
United States (46) · Germany (3) · Italy (3) · United Kingdom (2) · Canada (1) · France (1) · Ireland (1) · Netherlands (1) · Spain (1) · Switzerland (1)
Paul Martin (3) · Brenda Sandmaier (2) · Colleen Delaney (2) · George Chen (2) · Ryotaro Nakamura (2) · Ann Woolfrey (1) · B. Smith (1) · Boglarka Gyurkocza (1) · Christopher Porter (1) · David Maloney (1) · Douglas Ross (1) · Gregory Yanik, MD (1) · Gunnar Ragnarsson (1) · H. Joachim Deeg (1) · Hillard Lazarus (1)
PMID 32499241, PMID 18698002, PMID 21791475, PMID 22259028, PMID 23443507, PMID 24362550, PMID 24474568, PMID 26764356, PMID 26853648, PMID 28817727, PMID 30562587, PMID 32628342, PMID 33420905, PMID 35445027, PMID 36282798, PMID 38033284
P30CA015704 (8), P01CA018029 (5), N01CM62202 (2), P01HL036444 (2), RC2HL101844 (2), U01CA070095 (2), 2015 (1), 2023 (1), P01CA015396 (1), P01CA078902 (1), P30CA006973 (1), P30CA036727 (1), P30CA046592 (1), P30CA046934 (1), P30CA072720 (1)