11 completed, 2 recruiting, 2 terminated. 7 Phase 2, 5 Phase 3, 3 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 5, Terminated 2 |
| Phase 3 | 5 | Completed 3, Recruiting 2 |
| Phase 1 | 3 | Terminated 2, Completed 1 |
| Phase 4 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of MACI in Patients Aged 17 to 65 Years With Symptomatic Chondral or Osteochondral Defects of the Ankle autologous cultured chondrocytes on porcine collagen membrane, Bone Marrow Stimulation - Chondral Defect, Articular Cartilage Defect | Phase 3 | Recruiting | Vericel Corporation | 309 | 2026-05-28 | 2026-07-23 |
| A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee MACI, microfracture - Chondral Defect, Osteochondritis Dissecans (OCD) | Phase 3 | Recruiting | Vericel Corporation | 45 | 2018-10-24 | 2026-10-13 |
| An Efficacy, Safety and Tolerability Study of Ixmyelocel-T Administered Via Transendocardial Catheter-based Injections to Subjects With Heart Failure Due to Ischemic Dilated Cardiomyopathy (IDCM) ixmyelocel-T, Placebo - Ischemic Dilated Cardiomyopathy (IDCM) | Phase 2 | Completed | Vericel Corporation | 114 | 2013-02-20 | 2021-05-27 |
| An Efficacy and Safety Study of Ixmyelocel-T in Patients With Critical Limb Ischemia (CLI) Ixmyelocel-T, Placebo - Critical Limb Ischemia | Phase 3 | Completed | Vericel Corporation | 41 | 2012-02-01 | 2021-05-27 |
| Extension Study for Participants of MACI00206 Study of MACI® for the Treatment of Symptomatic Articular Cartilage Defects of the Knee autologous cultured chondrocytes on porcine collagen membrane, Microfracture - Articular Cartilage Defects | Completed | Vericel Corporation | 128 | 2010-12-01 | 2021-05-12 | |
| Use of Ixmyelocel-T (Formerly Catheter-based Cardiac Repair Cell [CRC]) Treatment in Patients With Heart Failure Due to Dilated Cardiomyopathy Ixmyelocel-T, Vehicle Control - Dilated Cardiomyopathy | Phase 2 | Completed | Vericel Corporation | 22 | 2009-12-01 | 2021-05-27 |
| Use of Ixmyelocel-T (Formerly Cardiac Repair Cell [CRC] Treatment) in Patients With Heart Failure Due to Dilated Cardiomyopathy (IMPACT-DCM) Ixmyelocel-T, Standard of Care - Dilated Cardiomyopathy | Phase 2 | Completed | Vericel Corporation | 40 | 2008-09-01 | 2021-05-27 |
| Superiority of MACI® Versus Microfracture Treatment in Patients With Symptomatic Articular Cartilage Defects in the Knee autologous cultured chondrocytes on porcine collagen membrane, Microfracture - Articular Cartilage Defect | Phase 3 | Completed | Vericel Corporation | 144 | 2008-07-01 | 2021-05-12 |
| Treatment of Alveolar Bone Defects Using Aastrom Biosciences Autologous Tissue Repair Cell Therapy Tissue Repair Cells (TRC), Control - Alveolar Bone Loss | Phase 1 / Phase 2 | Completed | University of Michigan | 24 | 2008-06-01 | 2015-07-03 |
| Ixmyelocel-T Treatment of Patients With Osteonecrosis of the Femoral Head Ixmyelocel-T, Standard of Care Only - Osteonecrosis | Phase 3 | Completed | Vericel Corporation | 11 | 2007-09-01 | 2019-10-21 |
| Use of Ixmyelocel-T (Formerly Vascular Repair Cells [VRC]) in Patients With Peripheral Arterial Disease to Treat Critical Limb Ischemia Ixmyelocel-T, Placebo - Peripheral Arterial Disease | Phase 2 | Completed | Vericel Corporation | 86 | 2007-04-01 | 2020-05-20 |
| Use of TRC Autologous Bone Marrow Cells in Posterolateral Lumbar Spine Fusion Bone Repair Cells (BRCs), Autologous bone graft - Single Level Posterolateral Spinal Fusion | Phase 1 / Phase 2 | Terminated | Vericel Corporation | 2 | 2006-04-01 | 2021-05-11 |
| Feasibility Study of Aastrom Tissue Repair Cells to Treat Non-Union Fractures. Fracture surgery, Cultured Bone Marrow Tissue - Fracture, Ununited, Pseudarthrosis | Phase 1 / Phase 2 | Terminated | Vericel Corporation | 36 | 2003-10-01 | 2021-05-11 |
| Study of the Treatment of Articular Repair (STAR) Carticel (autologous cultured chondrocyte) implantation - Articular Cartilage | Phase 4 | Completed | Vericel Corporation | 126 | 2000-03-01 | 2021-05-11 |
| The Objectives of the Cartilage Repair Registry is to Report Long Term Efficacy and Safety of Cartilage Repair Procedures in Registry Patients Carticel (autologous cultured chondrocyte) implantation - Articular Cartilage, Cartilage Diseases | Completed | Vericel Corporation | 2233 | 1995-03-01 | 2021-05-11 |
Cardiomyopathy, Dilated (2) · Cartilage Diseases (2) · Chronic Limb-Threatening Ischemia (2) · Fractures, Stress (2) · Peripheral Vascular Diseases (2) · Alveolar Bone Loss (1) · Bone Diseases (1) · Connective Tissue Diseases (1) · Fractures, Bone (1) · Fractures, Ununited (1) · Heart Failure (1) · Ischemia (1) · Musculoskeletal Diseases (1) · Osteochondritis (1) · Osteochondritis Dissecans (1)
Arthroplasty, Subchondral (3) · Drug Implants (2) · Gelatin Sponge, Absorbable (1) · Standard of Care (1)
United States (12) · Canada (2) · Czechia (2) · France (2) · Netherlands (2) · Norway (2) · Poland (2) · Sweden (2) · United Kingdom (2)
Amit Patel, MD (1) · Anthony J Comerota, MD (1) · Darnell Kaigler, DDS, MS, PhD (1) · Harry Herkowitz, MD (1) · James Goulet, MD (1) · Jonathan Hopper, BSc (Hons), MB ChB, FRCSEd (1) · Marc Hungerford, MD (1) · Matthew Jimenez, MD (1) · Steven Goldstein, PhD (1) · Thomas Lyon, MD (1) · Timothy Henry, MD (1) · William V Giannobile, DDS, DMedSc (1)
PMID 25142002, PMID 18927254, PMID 21684715, PMID 22453769, PMID 22776413, PMID 24714783, PMID 27059887, PMID 35802393
2009 (1)