8 completed, 5 unknown, 4 recruiting, 1 terminated. 7 Phase 4, 6 Phase 2, 3 Not applicable, 2 Phase 1, 1 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Changes in MTX-PG Concentrations During Subcutaneous MTX Therapy in Patients With Rheumatoid Arthritis(COSMOS Study) Methotrexate (MTX) - Rheumatoid Arthritis (RA) | Phase 4 | Recruiting | Keio University | 100 | 2025-04-10 | 2025-04-06 |
| Low-intensity Versus Medium-intensity Continuous Kidney Replacement Therapy for Critically Ill Patients Dialysate fluid, Filtration replacement fluid - Acute Kidney Injury Requiring Continuous Renal Replacement Therapy | Phase 2 / Phase 3 | Recruiting | Jikei University School of Medicine | 400 | 2023-10-30 | 2026-08-05 |
| Development and Evaluation of AI Program for Predicting Bacterial Species From Urine Gram Stain Specimens Bacterial Infections | Recruiting | GramEye | 15000 | 2023-09-25 | 2024-08-15 | |
| Development and Evaluation of Rapid Bacterial Species Identification for Acid-Fast Bacilli Smear Using Image Analysis AI Bacterial Infections | Recruiting | GramEye | 10000 | 2023-09-20 | 2024-07-26 | |
| Enhanced Human Sensorimotor Integration Via Self-modulation of the Somatosensory Activity Neurofeedback, Sham-feedback - Somatosensory Evoked Potentials, and Electroencephalography | Not applicable | Completed | Keio University | 39 | 2023-05-10 | 2025-02-07 |
| Satralizumab in the Treatment of Pulmonary Arterial Hypertension (SATISFY-JP Trial) Satralizumab (Genetical Recombination) - Pulmonary Arterial Hypertension | Phase 2 | Completed | International University of Health and Welfare | 20 | 2022-07-12 | 2026-07-15 |
| Imatinib Mesylate in Combination With Pembrolizumab in Patients With Melanoma Pembrolizumab and Imatinib mesylate - Melanoma | Phase 1 / Phase 2 | Unknown | Keio University | 22 | 2020-09-14 | 2023-10-03 |
| Cognitive Function Evaluation and Rehabilitation by a Digital Game: MentalPlus® MentalPlus® - Neuropsychological Test | Not applicable | Completed | University of Sao Paulo | 163 | 2020-07-08 | 2024-03-07 |
| Prospective Trial to Evaluate the Safety and Efficacy to Treat Esophageal Cancer Using 5-FU, Oxaliplatin, and Docetaxel FLOT therapy - Esophageal Squamous Cell Carcinoma | Phase 2 | Unknown | Keio University | 60 | 2020-06-25 | 2022-08-17 |
| Evaluation of the Optimal MTX Dose as an Add-on Therapy to Adalimumab for RA Patients in Japan, South Korea and Taiwan Methotrexate, Adalimumab - Rheumatoid Arthritis | Phase 4 | Completed | Keio University | 300 | 2018-04-18 | 2025-03-06 |
| CervIcal Cancer Screening Trial by Randomization of HPV Testing Intervention for Upcoming Screening （CITRUS Study） LBC, LBC plus HPV DNA testing - Cervical Cancer | Phase 4 | Completed | Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan | 18471 | 2013-06-07 | 2023-06-26 |
| Comparative Study of the Magnetically Guided Capsule Endoscopy Versus High Definition Gastroscopy Magnetically Guided Capsule (MGCE) - Gastric Focal Lesion | Not applicable | Completed | Universitätsklinikum Hamburg-Eppendorf | 189 | 2011-11-01 | 2019-06-18 |
| Efficacy and Safety of Adalimumab 80 mg Every Other Week With Methotrexate Adalimumab - Rheumatoid Arthritis | Phase 4 | Unknown | Keio University | 40 | 2011-01-01 | 2011-06-27 |
| Confocal Microscopy and Lacrimal Gland in Sjogren's Syndrome Primary Sjogren's Syndrome | Unknown | Keio University | 30 | 2007-10-01 | 2009-06-15 | |
| Bucillamine Study of Holding Remission After Infliximab Dose-off bucillamine, methotrexate - Rheumatoid Arthritis | Phase 4 | Unknown | Saitama Medical University | 40 | 2007-01-01 | 2011-01-05 |
| Safety and Efficacy of Unrelated Cord Blood Transplantation for Adult Patients With Hematologic Malignancies Cord blood transplantation, TBI, cyclophosphamide - Acute Myelogenous Leukemia, Acute Lymphoblastic Leukemia | Phase 1 / Phase 2 | Completed | Keio University | 33 | 2006-01-01 | 2012-04-06 |
| Comparison of Intravenous Omeprazole to Ranitidine on Recurrent Bleeding After Endoscopic Treatment of Bleeding Ulcer Omeprazole, Ranitidine - Peptic Ulcers | Phase 4 | Withdrawn | Keio University | 2005-10-01 | 2015-04-03 | |
| Safety and Efficacy Study of Salvage Chemotherapy (R-ESHAP) to Treat Relapsed and Refractory Aggressive Non-Hodgkin's Lymphoma Rituximab, Etoposide, Methylprednisolone, Cytarabine, Cisplatin - Lymphoma, Non-Hodgkin | Phase 2 | Terminated | Keio University | 5 | 2005-08-01 | 2007-11-20 |
| Combination of Glinides With Premixed Insulin nateglinide(drug) mitiglinide(drug) - Type 2 Diabets Mellitus | Phase 4 | Completed | Keio University | 60 | 2004-07-01 | 2009-08-26 |
Arthritis, Rheumatoid (4) · Bacterial Infections (2) · Autoimmune Diseases (1) · Connective Tissue Diseases (1) · Dry Eye Syndromes (1) · Esophageal Squamous Cell Carcinoma (1) · Hematologic Neoplasms (1) · Hypertension (1) · Inflammation (1) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (1) · Leukemia, Myeloid, Acute (1) · Lymphoma, Non-Hodgkin (1) · Melanoma (1) · Myelodysplastic Syndromes (1) · Peptic Ulcer (1)
Methotrexate (3) · Adalimumab (2) · Cytarabine (2) · AKAP13 protein, human (1) · Cisplatin (1) · Cord Blood Stem Cell Transplantation (1) · Cyclophosphamide (1) · Etoposide (1) · Imatinib Mesylate (1) · Methylprednisolone (1) · Neurofeedback (1) · Omeprazole (1) · Ranitidine (1) · Rituximab (1) · bucillamine (1)
Japan (17) · Brazil (1) · France (1) · South Korea (1) · Taiwan (1)
Akira Shimada, MD, PhD (1) · Hidekazu Suzuki, M.D., Ph.D. (1) · Hisashi Sakamaki, M.D., Ph.D. (1) · J F Rey, MD (1) · Kazuo Tsubota, Professor (1) · Livia S Valentin, Ph.D (1) · Norihiro Awaya, MD, PhD (1) · Satoshi Kutsuna, PhD,MD (1) · Takeru Funakoshi, MD (1) · Tomoko Fujii, MD,PhD (1) · Toshifumi Hibi, M.D., Ph.D. (1) · Yoshihito Atsumi, MD (1) · Yuichi Tamura (1) · Yuko Kaneko, MD, PhD (1)
PMID 24618504, PMID 28818742, PMID 34889232, PMID 38251524, PMID 39874232, PMID 40779331