21 completed, 5 unknown, 4 recruiting, 4 terminated. 38 Phase 2, 5 Phase 3, 4 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| 18F FES-PET/MRI for Tailoring Treatment of Luminal A and Lobular Breast Cancer FES, PET/MRI A, Translational analysis - Breast Cancer Female, Lobular Breast Carcinoma | Phase 2 | Recruiting | Università Vita-Salute San Raffaele | 119 | 2026-06-09 | 2026-06-12 |
| Pragmatic Study to Optimize Neoadjuvant Treatment and Surgical De-escalation in HR+/HER2- Early Breast Cancer Using Oncotype DX and Abemaciclib Abemaciclib - Breast Cancer, HER2 + Breast Cancer | Phase 2 | Not yet recruiting | Mario Negri Institute for Pharmacological Research | 150 | 2026-04-30 | 2026-03-05 |
| Cangrelor on Top of anticoagUlation in Patients With myocaRdial Infarction-related Cardiogenic Shock/Cardiac Arrest receiVIng VA-ECMO Cangrelor - Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication | Phase 2 | Recruiting | IRCCS San Raffaele | 50 | 2024-04-01 | 2025-01-27 |
| Fully Hybrid 18F-PSMA PET/MRI as One-stop Approach for the Diagnosis of Clinically Significant Prostate Cancer. PET/MRI - Clinical Suspicion of Prostate Cancer | Phase 2 | Recruiting | IRCCS San Raffaele | 167 | 2023-12-04 | 2026-04-01 |
| 18F-PSMA PET/MRI for the Diagnosis of Clinically Significant Prostate Cancer 18F-PSMA-1007 - Prostate Cancer | Phase 2 | Withdrawn | IRCCS San Raffaele | 2023-04-30 | 2025-04-13 | |
| Phase 2 Study of Neoadjuvant PEMbrolizumab Before Radical PROstatectomy in High-risk Prostate Cancer Patients Pembrolizumab - Prostate Cancer | Phase 2 | Withdrawn | IRCCS San Raffaele | 2023-04-10 | 2026-05-15 | |
| Open-label, Pivotal Clinical Trial to Confirm Efficacy and Safety of Autologous Grafts Containing Stem Cells Genetically Modified for Epidermis Restoration in Patients With Junctional Epidermolysis Bullosa Transplantation - Junctional Epidermolysis Bullosa Non-Herlitz Type | Phase 2 / Phase 3 | Terminated | Holostem s.r.l. | 2 | 2022-07-15 | 2025-02-19 |
| Sacituzumab Govitecan, Preceding Radical Cystectomy, in Treating Patients With Muscle-invasive Bladder Cancer Sacituzumab govitecan - Urothelial Carcinoma | Phase 2 | Completed | IRCCS San Raffaele | 44 | 2022-03-23 | 2026-03-27 |
| An Open Label, Single-arm, Phase 2 Study of Neoadjuvant Nivolumab and Nab-paclitaxel Before Radical Cystectomy for Patients With Muscle-invasive Bladder Cancer (NURE-Combo) Nivolumab + Nab-paclitaxel, Nivolumab - Muscle-Invasive Bladder Carcinoma | Phase 2 | Unknown | IRCCS San Raffaele | 29 | 2022-01-27 | 2022-04-06 |
| Imaging Guided Surgery to Improve the Detection of Lymph Node Metastases in Prostate Cancer Patients 99m-TC-PSMA-I&S - Prostate Cancer | Phase 2 | Completed | IRCCS San Raffaele | 81 | 2021-05-15 | 2025-03-14 |
| PET/MRI to Stage Prostate Cancer Patients 68Ga-PSMA, 68Ga-RM2 - Prostate Cancer | Phase 2 | Unknown | IRCCS San Raffaele | 50 | 2020-09-09 | 2024-07-03 |
| PET/MR for Prostate Cancer Restaging: a Phase II Prospective Monocentric Study 68Ga-PSMA, 68Ga-RM2 - Prostate Cancer | Phase 2 | Completed | IRCCS San Raffaele | 60 | 2020-06-03 | 2023-04-10 |
| Defibrotide in COVID-19 Pneumonia Defibrotide Injection - Patients With COVID-19 Pneumonia Will Allow to Detect an Absolute Reduction in the Rate of Respiratory-failure | Phase 2 | Completed | IRCCS San Raffaele | 50 | 2020-05-20 | 2022-07-19 |
| Effects of Fractional CO2 Laser Treatment on Vaginal Symptoms and Sexual Dysfunction in Women With Systemic Sclerosis CO2 Vaginal Laser - Systemic Sclerosis, Vulvovaginal Signs and Symptoms | Phase 2 / Phase 3 | Completed | IRCCS San Raffaele | 16 | 2020-05-01 | 2024-01-30 |
| Neoadjuvant PRRT With 177Lu-DOTATATE Followed by Surgery for Resectable PanNET 177Lu-Dotatate - Neuroendocrine Tumors | Phase 2 | Completed | IRCCS San Raffaele | 31 | 2020-03-09 | 2023-06-27 |
| Colchicine for Amyotrophic Lateral Sclerosis Colchicine 1 MG Oral Tablet, Placebo Oral Tablet - Amyotrophic Lateral Sclerosis | Phase 2 | Completed | Azienda Ospedaliero-Universitaria di Modena | 54 | 2019-04-10 | 2023-03-01 |
| A Phase I/II Study Evaluating Temferon in Multiple Myeloma Patients With Early Relapse After Front Line Therapy (TEM-MM) Temferon - Multiple Myeloma | Phase 1 / Phase 2 | Terminated | Genenta Science | 9 | 2019-03-06 | 2022-01-28 |
| Effects of Ranolazine on Coronary Microvascular Dysfunction in Patients With Hypertrophic Cardiomyopathy Ranolazine PR (prolonged-release) 500 mg 1 tablet bis in die and 750 mg 1 tablet bis in die - HCM - Hypertrophic Non-Obstructive Cardiomyopathy | Phase 2 | Completed | IRCCS San Raffaele | 26 | 2016-10-01 | 2020-12-10 |
| Combination of Ibuprofen, G-CSF and Plerixafor as Stem Cells Mobilization Regimen in Patients Affected by X-CGD Ibuprofen, Myelostim, Mozobil - Chronic Granulomatous Disease X-linked (X-CGD) | Phase 2 | Recruiting | IRCCS San Raffaele | 3 | 2015-11-06 | 2025-09-18 |
| Allogeneic Stem Cell Transplantation in Chronic Myeloid Leukemia Failing TKIs Therapy Bosutinib, Bone Marrow Transplant, Bone Marrow cells - Leukemia, Myelogenous | Phase 2 | Completed | University of Milano Bicocca | 2 | 2015-11-01 | 2020-11-05 |
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Pancreatic Neoplasms (8) · Prostatic Neoplasms (5) · Leukemia (2) · Lymphoma, Large B-Cell, Diffuse (2) · Multiple Myeloma (2) · Acute Coronary Syndrome (1) · Amyotrophic Lateral Sclerosis (1) · Angina Pectoris (1) · Arrhythmias, Cardiac (1) · Biliary Tract Neoplasms (1) · Breast Neoplasms (1) · Bronchiolitis Obliterans Syndrome (1) · COVID-19 (1) · Carcinoma, Lobular (1) · Carcinoma, Transitional Cell (1)
Capecitabine (6) · Cisplatin (5) · Gemcitabine (5) · Epirubicin (4) · 130-nm albumin-bound paclitaxel (2) · Albumin-Bound Paclitaxel (2) · BAY 86-7548 (2) · Mitomycin (2) · gallium 68 PSMA-11 (2) · Atorvastatin (1) · Bone Marrow Transplantation (1) · Colchicine (1) · Docetaxel (1) · Docosahexaenoic Acids (1) · Fluorouracil (1)
Italy (36) · France (1)
Michele Reni, MD (8) · Fabio Ciceri, MD (2) · Alessandro Aiuti, MD, PhD (1) · Andrea Necchi, MD (1) · Antonio Colombo, MD (1) · Arturo Chiti, MD (1) · Bordignon Claudio, MD (1) · Carlo Gambacorti-Passerini, MD (1) · Cristina Magnoni, MD, Surgeon (1) · Emanuele Bosi, MD (1) · Fabio Ciceri, MD, PhD (1) · Fabio FC Ciceri, MD (1) · Francesco M Serino, MD (1) · Franco Locatelli, MD, PhD (1)
PMID 12213959, PMID 15834546, PMID 16973674, PMID 16990385, PMID 18218852, PMID 18403219, PMID 19179314, PMID 19633200, PMID 19652199, PMID 22184407, PMID 23410167, PMID 23652021, PMID 23834234, PMID 24184488, PMID 25446328, PMID 27404453, PMID 28219694, PMID 29357859, PMID 29625841, PMID 30149366, PMID 30220407, PMID 31152038, PMID 34568066, PMID 35879127, PMID 39241203, PMID 42218654
2005 (2), 2008 (2), 2014 (1), 2015 (1)