2 completed, 2 recruiting, 1 active not recruiting, 1 not yet recruiting. 6 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 6 | Completed 2, Recruiting 2, Active not recruiting 1, Not yet recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| RB-PDT for Fusarium Keratitis: The LUMIERE Study Rose Bengal Photodynamic Therapy, Sham RB-PDT - Fusarium Keratitis | Phase 3 | Not yet recruiting | Stanford University | 434 | 2027-01-01 | 2026-08-17 |
| Fungal Ulcer Treatment Augmented With Natamycin and Cyclosporine A Cyclosporine A, Placebo Comparator: Placebo - Fungal Keratitis, Corneal Ulcer | Phase 3 | Recruiting | University of California, San Francisco | 150 | 2025-09-01 | 2026-06-05 |
| Parasitic Ulcer Treatment Trial Polyhexamethylene biguanide (PHMB), Topical corticosteroid, Topical placebo - Acanthamoeba Keratitis | Phase 3 | Recruiting | Jeremy Keenan, MD, MPH | 232 | 2024-07-01 | 2026-10-01 |
| Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction II Difluprednate Ophthalmic, Rose Bengal, Moxifloxacin Ophthalmic - Bacterial Keratitis | Phase 3 | Active not recruiting | University of California, San Francisco | 60 | 2024-07-01 | 2026-08-17 |
| Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction Moxifloxacin Ophthalmic, Chlorhexidine Gluconate, Natamycin - Acanthamoeba Keratitis, Fungal Keratitis | Phase 3 | Completed | University of California, San Francisco | 330 | 2022-08-03 | 2026-09-03 |
| Steroids and Cross-linking for Ulcer Treatment Moxifloxacin Ophthalmic, Difluprednate Ophthalmic, Riboflavin Ophthalmic - Keratitis Bacterial | Phase 3 | Completed | Thomas M. Lietman | 280 | 2020-09-24 | 2025-02-03 |
Acanthamoeba Keratitis (2) · Corneal Ulcer (2)
Corneal Cross-Linking (3) · Rose Bengal (2) · Adrenal Cortex Hormones (1) · Cyclosporine (1) · Natamycin (1) · chlorhexidine gluconate (1) · polihexanide (1)
India (6) · Brazil (4) · United States (4) · United Kingdom (1)
Jennifer Rose-Nussbaumer, MD (3) · Nicole Varnado, MPH (3) · Tom Lietman, MD (2) · Gerami D Seitzman, MD (1) · Gerami Seitzman, MD (1) · Jeremy Keenan, MD, MPH (1) · Thomas Lietman, MD (1)
PMID 34901464, PMID 38112645, PMID 39011096, PMID 39192339, PMID 40705354, PMID 41561665, PMID 42348235
UG1EY028518 (2), UG1EY033284 (1)