141 completed, 54 unknown, 31 terminated, 17 withdrawn. 95 Phase 2, 90 Not applicable, 43 Phase 1, 41 Phase 3, 26 Phase 4.
Follow Vitamin C: new trials by email Literature Review of Vitamin C trials Research Report on Vitamin C
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Vitamin C Administration on Intraoperative Bleeding in Patients Undergoing Sinusoscopy Ascorbic acid, Placebo - Chronic Rhinosinusitis, Intraoperative Bleeding | Phase 2 | Not yet recruiting | Assiut University | 78 | 2026-11-01 | 2026-10-08 |
| Injectable Platelet-Rich Fibrin and Microneedling With or Without Vitamin C for Gingival Phenotype Augmentation. Microneedling, Injectable Platelet-Rich Fibrin (i-PRF), Vitamin C - Thin Gingival Phenotype | Not applicable | Not yet recruiting | University of Science and Technology, Yemen | 27 | 2026-10-01 | 2026-10-06 |
| NCT + PD1 + Ketogenic Diet and/or Vitamin C for LARC Short-Course Radiotherapy, PD-1 monoclonal antibody, mFOLFOX6 regimen - Rectal Adenocarcinoma, High-Risk Cancer | Phase 2 | Not yet recruiting | Sixth Affiliated Hospital, Sun Yat-sen University | 100 | 2026-09-01 | 2026-08-14 |
| Parenteral Ascorbic Acid Repletion in TransplantatIon Ascorbic acid, Placebo - Liver Transplant Failure and Rejection | Phase 4 | Withdrawn | University of Wisconsin, Madison | 2026-09-01 | 2026-09-18 | |
| High-Dose Vitamin C in G6PDA and Pyruvate Kinase Deficiency: A Safety Study Vitamin C - Pyruvate Kinase Deficiency, Glucose 6 Phosphate Dehydrogenase Deficiency | Phase 1 | Not yet recruiting | University of Utah | 3 | 2026-07-15 | 2026-05-28 |
| Renoprotective Role of Vitamin C and Coenzyme Q10 in Nephrotoxicity Vitamin C, Coenzyme Q 10 - Nephrotoxicity | Phase 2 / Phase 3 | Not yet recruiting | Ain Shams University | 75 | 2026-04-20 | 2026-03-17 |
| Vitamin C for Acute Kidney Injury in ACLF With Septic Shock: A Randomized Controlled Trial Vitamin C, Standard of Care (SOC) - Acute-on-Chronic Liver Failure (ACLF) | Not applicable | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 110 | 2026-04-01 | 2026-03-25 |
| High-dose Ascorbate (HDA) in Combination With Standard of Care Azacitidine and Venetoclax in Acute Myeloid Leukemia (AML) Azacitidine, Venetoclax, High-dose ascorbate - Acute Myeloid Leukemia | Phase 1 | Recruiting | Kittika Poonsombudlert | 30 | 2026-03-18 | 2026-08-31 |
| Ascorbate in Myelodysplastic Syndrome High-dose ascorbate, Azacitidine - Myelodysplastic Syndromes | Phase 2 | Suspended | Prajwal Dhakal | 38 | 2026-03-11 | 2026-10-09 |
| Effect of Co-enzyme Q10 and Vitamin C Alone or in Combination After a Surgical Gingival Depigmentation surgical depigmentation, Coenzyme Q10, Vitamin C - Depigmentation Treatment, Depigmentation | Not applicable | Recruiting | Al-Azhar University | 20 | 2026-03-02 | 2026-07-01 |
| A Clinical Trial Evaluating the Effect of Pharmacological Ascorbate on Radiation Therapy for Pancreatic Cancer Patients Ascorbate, Gemcitabine, radiation therapy - Pancreatic Neoplasm | Phase 2 | Withdrawn | Joseph J. Cullen, MD, FACS | 2025-12-31 | 2025-03-10 | |
| Effect of Vitamin C on Pain Reduction After an Emergency Department Visit Vitamin C, Placebo - Pain, Acute | Not applicable | Recruiting | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | 204 | 2025-09-01 | 2026-03-02 |
| Effect of Vitamin C on Length of Hospital Stay in Children With Severe Pneumonia Antibiotics administration, Vitamin C - Pneumonia Childhood, Vitamin C | Phase 4 | Recruiting | Children's Hospital and Institute of Child Health, Multan | 90 | 2025-08-28 | 2026-02-17 |
| Impact of Vitamin C on Pain Detection and Tolerance Threshold Vitamin C, Placebo - Pain, Acute | Not applicable | Completed | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | 38 | 2025-07-18 | 2026-03-31 |
| Efficacy of Microneedling With Vitamin C in Performing Gingival Depigmentation Vitamin C, Microneedling, Diode laser - Gingival Pigmentation | Phase 1 / Phase 2 | Not yet recruiting | Fayoum University | 30 | 2025-07-01 | 2025-07-17 |
| Exploratory Study on the Role of Vitamin C in Promoting Health in Middle-Aged and Elderly Adults Vitamin C, Placebo - Ageing | Not applicable | Recruiting | Peking University Third Hospital | 400 | 2025-04-02 | 2025-06-27 |
| Does Vitamin C Increase the Body Heat Generated By The Nervous System? Vitamin C - Metabolism Changes, Vitamin D | Not applicable | Active not recruiting | Colorado State University | 20 | 2025-03-17 | 2026-07-02 |
| The Effect of VitC on IVF Outcome of DOR Patients Vitamin C, Placebo - Diminished Ovarian Reserve, IVF Outcomes | Not applicable | Recruiting | Peking University Third Hospital | 1100 | 2025-03-17 | 2025-06-17 |
| Analgesic and Anti-inflamatory Effect of Vit. B Vitamin B Complex, vitamin C, Placebo - Postoperative Pain, Acute | Not applicable | Not yet recruiting | Benha University | 90 | 2025-03-01 | 2025-03-04 |
| Impact of Vitamin C Supplementation on Hospital Outcomes in Children Undergoing Corrective Heart Surgery for Congenital Heart Diseases Vitamin C, Placebo - Congenital Heart Disease (CHD) | Not applicable | Not yet recruiting | Cairo University | 20 | 2025-02-19 | 2025-02-17 |
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Sepsis (22) · COVID-19 (20) · Shock, Septic (16) · Pancreatic Neoplasms (13) · Diabetes Mellitus, Type 2 (10) · Colorectal Neoplasms (8) · Coronavirus Infections (8) · Neoplasms (8) · Cardiovascular Diseases (7) · Diabetes Mellitus (7) · Anemia (6) · Ascorbic Acid Deficiency (6) · Acute Lung Injury (5) · Atrial Fibrillation (5) · Myelodysplastic Syndromes (5)
Ain Shams University (7) · Cairo University (7) · Virginia Commonwealth University (5) · Joseph J. Cullen, MD, FACS (4) · Thomas Jefferson University (4) · Augusta University (3) · Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal (3) · Fudan University (3) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (3) · ProgenaBiome (3) · Universitas Sriwijaya (3) · University of Kansas Medical Center (3) · Amsterdam UMC, location VUmc (2) · Benha University (2) · Brigham and Women's Hospital (2)
United States (114) · China (21) · Egypt (18) · Canada (17) · Netherlands (6) · Slovenia (6) · Spain (6) · United Kingdom (6) · Germany (5) · Mexico (5) · Belgium (4) · Israel (4) · Italy (4) · South Korea (4) · Turkey (Türkiye) (4)
Sabine Hazan, MD (3) · Channing Paller, MD (2) · Daniel A Monti, MD (2) · Guopei Luo, MD (2) · In-Young Choi, PhD (2) · John M. Buatti, MD (2) · Joseph J Cullen, MD, FACS (2) · Joseph J. Cullen, MD, FACS (2) · Junwen Ou, PhD (2) · Mark A Levine, M.D. (2) · Raoul Daoust, MD MSc (2) · Rui-hua Xu, MD.,PhD. (2) · Umesh Jain, MD (2) · Adele Diamond, PhD (1) · Adnan Agha (1)
PMID 19237716, PMID 28366679, PMID 31573637, PMID 33620405, PMID 37877585, PMID 37916745, PMID 1, PMID 10488881, PMID 10924859, PMID 11005733, PMID 11445675, PMID 11689441, PMID 14605526, PMID 15179561, PMID 15365964, PMID 15635556, PMID 15829878, PMID 16953900, PMID 17698683, PMID 17998490, PMID 18455517, PMID 18460663, PMID 18984888, PMID 18993042, PMID 18997197, PMID 19028251, PMID 19056591, PMID 19064521, PMID 19066368, PMID 19116389, PMID 19446899, PMID 19451353, PMID 19491213, PMID 19491386, PMID 19909499, PMID 20629665, PMID 20639713, PMID 21060040, PMID 21159788, PMID 21358394, PMID 21457291, PMID 21600541, PMID 21752095, PMID 21813807, PMID 22176653, PMID 22503302, PMID 22595020, PMID 22923162, PMID 23066166, PMID 23117775
P30CA086862 (4), U01CA140206 (3), 2014 (2), 2015 (2), P01CA217797 (2), 1UM1HL116885-01 (1), 2005 (1), 2016 (1), 2018 (1), 2023 (1), K23HL080231 (1), P01AT002620 (1), P01HL069999 (1), P30CA006973 (1), P30CA014089 (1)