42 completed, 17 unknown, 15 terminated, 8 withdrawn. 95 Phase 2, 16 Phase 1, 12 Phase 3.
Follow Vitamin C: new trials by email Literature Review of Vitamin C trials Research Report on Vitamin C
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Vitamin C Administration on Intraoperative Bleeding in Patients Undergoing Sinusoscopy Ascorbic acid, Placebo - Chronic Rhinosinusitis, Intraoperative Bleeding | Phase 2 | Not yet recruiting | Assiut University | 78 | 2026-11-01 | 2026-10-08 |
| NCT + PD1 + Ketogenic Diet and/or Vitamin C for LARC Short-Course Radiotherapy, PD-1 monoclonal antibody, mFOLFOX6 regimen - Rectal Adenocarcinoma, High-Risk Cancer | Phase 2 | Not yet recruiting | Sixth Affiliated Hospital, Sun Yat-sen University | 100 | 2026-09-01 | 2026-08-14 |
| Renoprotective Role of Vitamin C and Coenzyme Q10 in Nephrotoxicity Vitamin C, Coenzyme Q 10 - Nephrotoxicity | Phase 2 / Phase 3 | Not yet recruiting | Ain Shams University | 75 | 2026-04-20 | 2026-03-17 |
| Ascorbate in Myelodysplastic Syndrome High-dose ascorbate, Azacitidine - Myelodysplastic Syndromes | Phase 2 | Suspended | Prajwal Dhakal | 38 | 2026-03-11 | 2026-10-09 |
| A Clinical Trial Evaluating the Effect of Pharmacological Ascorbate on Radiation Therapy for Pancreatic Cancer Patients Ascorbate, Gemcitabine, radiation therapy - Pancreatic Neoplasm | Phase 2 | Withdrawn | Joseph J. Cullen, MD, FACS | 2025-12-31 | 2025-03-10 | |
| Efficacy of Microneedling With Vitamin C in Performing Gingival Depigmentation Vitamin C, Microneedling, Diode laser - Gingival Pigmentation | Phase 1 / Phase 2 | Not yet recruiting | Fayoum University | 30 | 2025-07-01 | 2025-07-17 |
| Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation Metformin, Rapamycin, Naltrexone - Longevity, GLP-1 | Phase 2 / Phase 3 | Recruiting | AgelessRx | 150 | 2024-12-17 | 2025-07-30 |
| Reducing Frailty for Older Cancer Survivors Using Supplements II Epigallocatechin-3-Gallate (EGCG), Microcrystalline cellulose (MCC), Ascorbic Acid (Vitamin C) - Frailty, Inflammation | Phase 2 | Suspended | University of Rochester | 118 | 2024-10-25 | 2026-06-26 |
| Adjunctive Intravenous Ascorbic Acid for Advanced Non-Small Cell Lung Cancer Ascorbic acid, Normal Saline - Lung Cancer | Phase 2 | Terminated | The Canadian College of Naturopathic Medicine | 3 | 2024-10-01 | 2026-10-14 |
| Effect of Vitamin C on Postoperative Pulmonary Complications After Intracranial Tumor Surgery Ascorbic acid, Saline - Ascorbic Acid, Neurosurgical Procedures | Phase 2 | Unknown | Qianfoshan Hospital | 86 | 2024-06-01 | 2024-05-20 |
| Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty Vitamin C, Placebo - Chronic Pain, Knee Pain Chronic | Phase 2 | Recruiting | University Health Network, Toronto | 400 | 2024-04-16 | 2026-06-23 |
| Effect of Vitamin C Supplementation in Patients With Primary Hypothyroidism Vitamin C, Oral Rehydration Salt Formulations - Hypothyroidism, Primary Hypothyroidism | Phase 2 | Unknown | Dr Adnan Agha | 40 | 2023-11-01 | 2024-01-11 |
| Vitamin C Effectiveness in Preventing Urinary Tract Infections After Gynecological Surgeries Ascorbic Acid 1000 MG, Placebo - Catheter-Associated Urinary Tract Infection | Phase 2 | Completed | American University of Beirut Medical Center | 200 | 2023-09-19 | 2026-10-28 |
| Vitamin C to Quality of Life in Patients With Terminal Stage Pancreatic Cancer Ascorbate - Metastatic Pancreatic Cancer, Terminal Cancer | Phase 2 | Unknown | Fudan University | 20 | 2023-08-25 | 2024-06-06 |
| Phase II Study of PARP Inhibitor Olaparib and IV Ascorbate in Castration Resistant Prostate Cancer Olaparib, Vitamin C - Prostate Cancer, Castration-resistant Prostate Cancer | Phase 2 | Terminated | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 4 | 2023-06-30 | 2025-01-29 |
| Perioperative Vitamin C Lung Transplant Vitamin C - Primary Graft Dysfunction, Lung Transplant; Complications | Phase 2 | Withdrawn | University of Wisconsin, Madison | 2023-04-01 | 2023-05-01 | |
| Immunonutrition for Diabetic Foot Ulcers Lovaza, L-Arginine Powder, Vitamin C - Diabetes Mellitus, Diabetic Peripheral Neuropathy | Phase 2 / Phase 3 | Terminated | Prisma Health-Midlands | 1 | 2023-02-08 | 2024-12-27 |
| Efficacy of Megadose Vitamin C in Severe and Critical Ill COVID-19 Patients. Vitamin C, Placebo - Vitamin C, COVID-19 Pneumonia | Phase 2 / Phase 3 | Unknown | Zhujiang Hospital | 608 | 2023-01-13 | 2023-01-23 |
| Clinical Efficacy of Megadose Vitamin C in Sepsis Vitamin C, 5% glucose injection - Sepsis, Septic Shock | Phase 2 | Completed | Zhujiang Hospital | 234 | 2022-02-08 | 2026-05-13 |
| Evaluation of Safety and Dosing of a Vitamin C Bundle for Sepsis Treatment in Africa Vitamin C, Vitamin B1 - Sepsis, Septic Shock | Phase 2 | Unknown | Liverpool School of Tropical Medicine | 60 | 2021-09-01 | 2021-09-08 |
Showing 20 of 95. Sign in to see all of them.
Pancreatic Neoplasms (10) · Sepsis (10) · Neoplasms (7) · Shock, Septic (7) · COVID-19 (6) · Carcinoma, Non-Small-Cell Lung (4) · Colorectal Neoplasms (4) · Myelodysplastic Syndromes (4) · Acute Lung Injury (3) · Leukemia, Myelomonocytic, Chronic (3) · Multiple Myeloma (3) · Ascorbic Acid Deficiency (2) · Breast Neoplasms (2) · Cardiovascular Diseases (2) · Coronavirus Infections (2)
Ain Shams University (4) · Thomas Jefferson University (4) · Virginia Commonwealth University (4) · Joseph J. Cullen, MD, FACS (3) · Clifford Hospital, Guangzhou, China (2) · Jeanne Drisko, MD, CNS, FACN (2) · ProgenaBiome (2) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2) · Zhujiang Hospital (2) · Academic Emergency County Hospital Sibiu (1) · Academic and Community Cancer Research United (1) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Aga Khan University (1) · AgelessRx (1) · American University of Beirut Medical Center (1)
United States (44) · China (10) · Canada (5) · Egypt (5) · Netherlands (3) · Spain (3) · Australia (2) · Brazil (1) · Denmark (1) · France (1) · Germany (1) · India (1) · Iran (1) · Mexico (1) · New Zealand (1)
Channing Paller, MD (2) · Daniel A Monti, MD (2) · Joseph J. Cullen, MD, FACS (2) · Junwen Ou, PhD (2) · Sabine Hazan, MD (2) · Adnan Agha (1) · Adolfo D. Rodriguez-Carrizalez, M.Sc. (1) · Ali Al-Mousawi, MD (1) · Alpha B. Fowler, MD (1) · Alpha Fowler, MD (1) · Amira B Kassem, PHD (1) · Andraes Pinter, Dr. (1) · Andrej Markota, MD, PhD, Assist. Prof. (1) · Angelique ME Spoelstra-de Man, Dr. (1)
PMID 37916745, PMID 17698683, PMID 18460663, PMID 18984888, PMID 19064521, PMID 19116389, PMID 19237716, PMID 19451353, PMID 19491213, PMID 19491386, PMID 19909499, PMID 22595020, PMID 23066166, PMID 23493062, PMID 24484547, PMID 24500406, PMID 28366679, PMID 29776960, PMID 31142242, PMID 31366980, PMID 31573637, PMID 31950979, PMID 31987106, PMID 32013700, PMID 32194058, PMID 32641343, PMID 34039021, PMID 34407846, PMID 34866234, PMID 34982738, PMID 35525024, PMID 36974245, PMID 37773633, PMID 38100226, PMID 38752063, PMID 39076107, PMID 39352751, PMID 39369582, PMID 40719561, PMID 41210509, PMID 42301311, PMID 5948222
P30CA086862 (3), P01CA217797 (2), U01CA140206 (2), 1UM1HL116885-01 (1), 2014 (1), 2016 (1), 2018 (1), P30CA006973 (1), P30CA015083 (1), P50CA097274 (1), R01HL046959 (1), U01AA026966 (1), U01HL052073 (1), UL1TR002366 (1)