21 completed, 6 terminated, 5 unknown, 4 withdrawn. 43 Phase 1, 16 Phase 2.
Follow Vitamin C: new trials by email Literature Review of Vitamin C trials Research Report on Vitamin C
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| High-Dose Vitamin C in G6PDA and Pyruvate Kinase Deficiency: A Safety Study Vitamin C - Pyruvate Kinase Deficiency, Glucose 6 Phosphate Dehydrogenase Deficiency | Phase 1 | Not yet recruiting | University of Utah | 3 | 2026-07-15 | 2026-05-28 |
| High-dose Ascorbate (HDA) in Combination With Standard of Care Azacitidine and Venetoclax in Acute Myeloid Leukemia (AML) Azacitidine, Venetoclax, High-dose ascorbate - Acute Myeloid Leukemia | Phase 1 | Recruiting | Kittika Poonsombudlert | 30 | 2026-03-18 | 2026-08-31 |
| Efficacy of Microneedling With Vitamin C in Performing Gingival Depigmentation Vitamin C, Microneedling, Diode laser - Gingival Pigmentation | Phase 1 / Phase 2 | Not yet recruiting | Fayoum University | 30 | 2025-07-01 | 2025-07-17 |
| Botensilimab Plus Balstilimab and Fasting Mimicking Diet Plus Vitamin C for Patients With KRAS-Mutant Metastatic Colorectal Cancer Balstilimab, Biospecimen Collection, Botensilimab - Metastatic Colorectal Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8 | Phase 1 | Recruiting | University of Southern California | 15 | 2025-01-15 | 2026-03-17 |
| Evaluation of Ascorbate-Meglumine Therapeutic for SRS Ascorbate-Meglumine - Safety | Phase 1 | Unknown | LadeRx LLC | 12 | 2024-09-09 | 2024-09-19 |
| A Safety Study of Pharmacologic Ascorbate and Ferumoxytol in Addition to Standard of Care Chemoradiation in Glioblastoma Ferumoxytol injection, Pharmacological ascorbate, External beam radiation therapy - Glioblastoma, Glioblastoma Multiforme | Phase 1 | Active not recruiting | Bryan Allen | 16 | 2023-02-28 | 2026-07-20 |
| Assessment of Gastric pH Changes Induced by Ascorbic Acid Tablets Omeprazole 20mg, Vitamin C - Hypochlorhydria | Phase 1 | Completed | Indiana University | 11 | 2021-10-01 | 2025-09-22 |
| SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem Cells Melphalan, BCNU, Vitamin B12B - Pancreatic Adenocarcinoma Metastatic, BRCA1 Mutation | Phase 1 | Recruiting | General Oncology, Inc. | 24 | 2021-01-13 | 2026-01-29 |
| Trial of Combination Therapy to Treat COVID-19 Infection Ivermectin, Doxycycline Hcl, Zinc - COVID, Covid-19 | Phase 1 | Completed | ProgenaBiome | 31 | 2020-12-09 | 2024-09-24 |
| Intravenous (IV) Vitamin C With Chemotherapy for Cisplatin Ineligible Bladder Cancer Patients Ascorbic Acid - Bladder Cancer | Phase 1 / Phase 2 | Active not recruiting | University of Kansas Medical Center | 12 | 2019-10-17 | 2025-03-25 |
| High Dose Ascorbate With Preoperative Radiation in Patients With Locally Advanced Soft Tissue Sarcomas Ascorbate - Soft Tissue Sarcoma | Phase 1 / Phase 2 | Completed | Mohammed Milhem | 25 | 2019-06-27 | 2026-06-18 |
| High Dose Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin + Gemcitabine (AA NABPLAGEM) in Patients Who Have Metastatic Pancreatic Cancer Ascorbic Acid, Paclitaxel protein-bound, Cisplatin - Metastatic Pancreatic Cancer, Pancreatic Cancer | Phase 1 / Phase 2 | Withdrawn | Hitendra Patel | 2019-06-01 | 2019-06-11 | |
| High Dose Ascorbic Acid and Nanoparticle Paclitaxel Protein Bound and Cisplatin and Gemcitabine (AA NABPLAGEM) in Patients Who Have Metastatic Pancreatic Cancer Ascorbic Acid, Paclitaxel protein-bound, Cisplatin - Metastatic Pancreatic Cancer, Pancreatic Cancer | Phase 1 / Phase 2 | Withdrawn | Medical College of Wisconsin | 2019-05-01 | 2019-05-30 | |
| High Dose Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin + Gemcitabine (AA NABPLAGEM) in Patients Who Have Metastatic Pancreatic Cancer Ascorbic Acid, nab paclitaxel, Cisplatin - Metastatic Pancreatic Cancer | Phase 1 / Phase 2 | Withdrawn | Piedmont Cancer Institute | 2019-01-01 | 2019-05-31 | |
| Vitamin C and Tyrosine Kinase Inhibitor in Lung Cancer Patients With Epidermal Growth Factor Receptor Mutations Vitamin C, Tyrosine kinase inhibitor - Carcinoma, Non-Small-Cell Lung | Phase 1 / Phase 2 | Unknown | Clifford Hospital, Guangzhou, China | 150 | 2018-12-05 | 2019-01-10 |
| Intravenous Ascorbic Acid Supplementation in Neoadjuvant Chemotherapy for Breast Cancer Ascorbic Acid, Placebos - Breast Cancer | Phase 1 / Phase 2 | Unknown | Academic Emergency County Hospital Sibiu | 30 | 2018-10-01 | 2018-06-27 |
| UVB-Induced MVP Release in Human Skin Vitamin C, Vitamin E - Ultraviolet B Radiation, Microvesicle Particles | Phase 1 | Completed | Wright State University | 8 | 2018-07-16 | 2023-02-24 |
| A Phase Ib Study Evaluating the Safety and Tolerability of Vitamin C in Patients With Intermediate or High Risk Myelodysplastic Syndrome With TET2 Mutations Vitamin C - Myelodysplastic Syndromes | Phase 1 / Phase 2 | Completed | NYU Langone Health | 4 | 2018-05-01 | 2024-03-27 |
| Differences by Sex and Genotype in the Effects of Stress on Executive Functions Methylphenidate, Vitamin C - Stress | Phase 1 | Unknown | University of British Columbia | 146 | 2018-04-28 | 2024-05-08 |
| Effects of Vitamin C Administration on Extravascular Lung Water in Patients With Severe Features of Preeclampsia Vitamin C, placebo - Preeclampsia Severe, Preeclampsia Postpartum | Phase 1 | Completed | University Medical Centre Ljubljana | 34 | 2018-04-07 | 2019-06-28 |
Showing 20 of 43. Sign in to see all of them.
Neoplasms (5) · Pancreatic Neoplasms (5) · Glioblastoma (3) · Asthma (2) · Breast Neoplasms (2) · Carcinoma, Non-Small-Cell Lung (2) · Colorectal Neoplasms (2) · Diabetes Mellitus, Type 2 (2) · Glioma (2) · Multiple Myeloma (2) · Recurrence (2) · Achlorhydria (1) · Acute Lung Injury (1) · Anemia, Hemolytic (1) · Atrial Fibrillation (1)
Clifford Hospital, Guangzhou, China (2) · Indiana University (2) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (2) · Thomas Jefferson University (2) · Virginia Commonwealth University (2) · Academic Emergency County Hospital Sibiu (1) · Al-Neelain University (1) · Boston University (1) · Bryan Allen (1) · Cedars-Sinai Medical Center (1) · Fayoum University (1) · Geisinger Clinic (1) · General Oncology, Inc. (1) · Hitendra Patel (1) · Jeanne Drisko, MD, CNS, FACN (1)
United States (35) · China (2) · Canada (1) · Israel (1) · Romania (1) · Slovenia (1) · Sudan (1)
John M. Buatti, MD (2) · Junwen Ou, PhD (2) · Mark A Levine, M.D. (2) · Adele Diamond, PhD (1) · Alpha Fowler, MD (1) · Arnold Glazier, M.D. (1) · Ben George, MD (1) · Daniel A Monti, MD (1) · Daniel A Monti, MD, MBA (1) · David B. Peden, MD, MS (1) · Deepak Singh, MD (1) · Diana Hanna, MD (1) · Donald F Brophy, PharmD (1) · Eunice Wang, MD (1) · Florin Grosu, MD,PhD (1)
PMID 23493062, PMID 24484547, PMID 24500406, PMID 28366679, PMID 30254147, PMID 31495886, PMID 31821172, PMID 33184629, PMID 33453456, PMID 35135310, PMID 36974245, PMID 38752063, PMID 39702045, PMID 5948222
P01AT002620 (1), P30CA014089 (1), P30CA036727 (1), P30CA086862 (1), R01DA037285 (1), R21CA270742 (1), R21DA041596 (1), U01CA140206 (1), UL1TR002366 (1)