9 recruiting, 4 completed, 3 unknown, 2 active not recruiting. 21 Not applicable, 2 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 21 | Recruiting 9, Completed 4, Unknown 3, Active not recruiting 2, Not yet recruiting 2, Enrolling by invitation 1 |
| Phase 2 | 2 | Terminated 1, Withdrawn 1 |
| Phase 1 | 1 | Withdrawn 1 |
Follow tVNS: new trials by email Literature Review of tVNS trials Research Report on tVNS
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Investigating the Neurophysiology of the Motor System and the Feasibility of Vagus Nerve Stimulation in Functional Neurological Disorder (FND) Vagial Nerve Stimulation (VNS) active stimulation, Vagial Nerve Stimulation (VNS) sham stimulation - Functional Neurological Disorder, Motor Symptoms | Not applicable | Not yet recruiting | University of Fribourg | 68 | 2026-07-01 | 2026-07-17 |
| Effects of Transcutaneous Vagus Nerve Stimulation in Parkinson´s Disease Transcutaneous Electrical Nerve Stimulation (TENS) of Vagus Nerve, Conventional Physical therapy, Conventional Speech Therapy - Transcutaneous Vagal Nerve Stimulation (tVNS), Parkinson Disease (PD) | Not applicable | Active not recruiting | Universidade da Coruña | 46 | 2026-05-25 | 2026-08-07 |
| Transcutaneous Auricular Vagus Nerve Stimulation for Insomnia in Survivors of Childhood Acute Lymphoblastic Leukemia Soterix tVNS device, Soterix tVNS device (sham programmed), Sleep Quality - Survivor of Childhood Cancer, Insomnia | Not applicable | Recruiting | St. Jude Children's Research Hospital | 40 | 2026-03-31 | 2026-08-14 |
| tVNS and Approach-Avoidance Behavior in Anhedonia and Anxiety tVNS, Sham - Healthy Participants, Anxiety Disorders (With High Anxiety Symptoms) | Not applicable | Recruiting | Dr. Nils B. Kroemer | 104 | 2026-03-23 | 2026-04-23 |
| Association of VAgus Nerve Stimulation and Treadmill Training for GAit Rehabilitation in DE Novo Parkinson's Disease Transcutaneous Auricular Vagus Nerve Stimulation (taVNS), Sham Transcutaneous Auricular Vagus Nerve Stimulation (Sham taVNS), Conventional Physical Therapy (cPT) - Idiopathic Parkinson's Disease (PD) | Not applicable | Recruiting | Fondazione Policlinico Universitario Campus Bio-Medico | 60 | 2026-02-14 | 2026-07-16 |
| The Effect of Transcutaneous Vagal Nerve Stimulation (tVNS) on Cerebral Vasospasm Secondary to Aneurysmal Subarachnoid Hemorrhage Transcutaneous Vagal Nerve Stimulation - Aneurysmal Subarachnoid Hemorrhage, Vasospasm, Cerebral | Not applicable | Recruiting | Marshall Holland | 10 | 2026-02-06 | 2026-08-11 |
| Effects of Transcutaneous Vagus Nerve Stimulation in Older Adults Active location tVNS, Sham Comparator - Older Adults Without Any Specific Clinical Condition, Autonomic Nervous System Imbalance | Not applicable | Completed | Universidade da Coruña | 12 | 2025-12-19 | 2026-03-02 |
| WISE-2B Brain Study (Weight Loss Intervention Surgical Effects on Brain Function) tVNS, Complete Vagotomy, Anterior Vagotomy - Diabetes, Weight Loss | Not applicable | Recruiting | University of Florida | 120 | 2025-11-10 | 2026-02-10 |
| Low-frequency Electrical Stimulation for Cognitive Enhancement in Atrial Fibrillation tVNS - Cognitive Function Abnormal, Atrial Fibrillation (AF) | Not applicable | Enrolling by invitation | Bakulev Scientific Center of Cardiovascular Surgery | 60 | 2025-09-09 | 2026-05-08 |
| Vagus Nerve Stimulation to the Ear to Improve Symptoms in Post-COVID-19 and ME/CFS transcutaneous vagus nerve stimulation - Post-COVID / Long-COVID, ME/CFS | Not applicable | Active not recruiting | University of Luxembourg | 48 | 2025-07-18 | 2025-08-08 |
| High Resolution Gastric Mapping and Gastroduodenal Manometry Alimetry, tVNS, Gastroduodenal Manometry - Dyspepsia | Not applicable | Recruiting | Mayo Clinic | 100 | 2025-07-11 | 2026-09-11 |
| Effects of Transcranial Electrical Stimulation in Chronic Stress tDCS, tVNS - Stress, Sleep | Not applicable | Not yet recruiting | Egas Moniz - Cooperativa de Ensino Superior, CRL | 100 | 2025-03-01 | 2025-02-06 |
| Transcutaneous Vagus Nerve Stimulation on Fibromyalgia- Double-blind, Sham-controlled Randomized Clinical Trial tVNS - Transcutaneous Vagus Nerve Stimulation on Fibromyalgia | Not applicable | Recruiting | National and Kapodistrian University of Athens | 120 | 2024-10-15 | 2025-04-04 |
| Neuromodulation of the Autonomic Nervous System in Athletes tVNS - Efficacy, Self, Fatigue; Muscle, Heart | Not applicable | Completed | Bakulev Scientific Center of Cardiovascular Surgery | 121 | 2024-04-01 | 2026-07-20 |
| Effects of Transcutaneous Electrical Nerve Stimulation on Cognitive Function and Upper Limb Motor Function in People With Chronic Stroke tSCS, tVNS, Control - Chronic Stroke | Not applicable | Recruiting | The Hong Kong Polytechnic University | 90 | 2023-11-01 | 2026-10-16 |
| Transcutaneous Cervical Vagus Nerve Stimulation (tcVNS) in JIA Active tcVNS, Sham tcVNS - Juvenile Idiopathic Arthritis (JIA) | Phase 2 | Terminated | National Institute of Allergy and Infectious Diseases (NIAID) | 18 | 2023-06-27 | 2025-11-25 |
| Paired tVNS With ERP in OCD Sham, tVNS - OCD | Not applicable | Recruiting | University of Florida | 56 | 2022-06-27 | 2026-07-09 |
| Neuromodulation of Inhibitory Control in Tic Disorders tVNS - Tic Disorders | Not applicable | Unknown | IRCCS Eugenio Medea | 26 | 2022-06-01 | 2022-03-02 |
| Stress and Sleep Study tVNS, Mindfulness, sham tVNS - Stress, Psychological, Sleep | Not applicable | Completed | University of Florida | 76 | 2022-02-09 | 2024-04-04 |
| Bulimia Nervosa and Binge Eating Disorder: Comparing Therapeutic Strategies tVNS, rTMS, CBT-E - Bulimia Nervosa, Binge-Eating Disorder | Not applicable | Unknown | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 30 | 2022-01-01 | 2022-04-22 |
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Fatigue (3) · Depression (2) · Parkinson Disease (2) · Tremor (2) · Anhedonia (1) · Anxiety Disorders (1) · Arthritis, Juvenile (1) · Atrial Fibrillation (1) · Binge-Eating Disorder (1) · Bulimia Nervosa (1) · Cognition Disorders (1) · Combat Disorders (1) · Communication Disorders (1) · Conversion Disorder (1) · Cough (1)
University of Florida (3) · Bakulev Scientific Center of Cardiovascular Surgery (2) · Universidade da Coruña (2) · Dr. Nils B. Kroemer (1) · Egas Moniz - Cooperativa de Ensino Superior, CRL (1) · Eindhoven University of Technology (1) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (1) · Fondazione Policlinico Universitario Campus Bio-Medico (1) · Georgia Institute of Technology (1) · IRCCS Eugenio Medea (1) · Marshall Holland (1) · Mayo Clinic (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · National and Kapodistrian University of Athens (1) · St. Jude Children's Research Hospital (1)
United States (8) · Italy (3) · Russia (2) · Spain (2) · Germany (1) · Greece (1) · Hong Kong (1) · Luxembourg (1) · Netherlands (1) · Portugal (1) · Switzerland (1)
Beth Gottlieb, MD (1) · Betty Diamond, MD (1) · Cristina Concetti, PhD (1) · Cynthia Aranow, MD (1) · Eric Porges, PhD (1) · John Williamson, PhD (1) · Justin E Tanner, PhD (1) · Liva LaMontagne, Dr. Psych. (1) · Marian M Majoie, Prof. Dr. (1) · Marshall Holland, MD (1) · Massimo Marano, MD, PhD (1) · Minoru Shinohara, PhD (1)
PMID 22037126, PMID 25874165, PMID 33799722, PMID 41397750, PMID 42287562
R01DK099334 (1), R03NS106088 (1)