17 completed, 3 unknown, 2 not yet recruiting, 2 recruiting. 18 Not applicable, 5 Phase 2, 1 Early Phase 1, 1 Phase 1, 1 Phase 3.
Follow Tryptophan: new trials by email Literature Review of Tryptophan trials Research Report on Tryptophan
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| MA of Tryptophan in Cornmeal in Healthy Adults>60y Tryptophan - Protein Absorption and Amino Acid Availability | Not applicable | Completed | The Hospital for Sick Children | 6 | 2025-11-29 | 2026-10-02 |
| Effects of Combined Administration of Calcium and L-tryptophan on Gut Functions and Blood Glucose in Healthy Humans L-tryptophan, Combination of L-tryptophan + Ca-500, Combination of L-tryptophan + Ca-1000 - Healthy | Not applicable | Not yet recruiting | University of Adelaide | 16 | 2025-06-28 | 2025-06-24 |
| Exploring the Influence of Trptophan on the Treatment of Pouchitis Tryptophan 25mg/kg bodyweight, Placebo - Pouchitis | Not applicable | Not yet recruiting | Universitätsklinikum Hamburg-Eppendorf | 20 | 2025-04-01 | 2025-03-06 |
| The Tryptophan Requirement in Healthy Adults Tryptophan - Healthy Aging | Not applicable | Recruiting | The Hospital for Sick Children | 40 | 2024-06-01 | 2025-05-30 |
| A Nutritional Intervention to Prevent Stress Induced Intestinal Hyper-Permeability Prebiotic, L-Tryptophan, Placebo - Stress, Psychological | Not applicable | Unknown | KU Leuven | 48 | 2023-10-10 | 2023-10-18 |
| Tryptophan for Impaired AhR Signaling in Celiac Disease L-Tryptophan, Freedom SimpleCap Powder - Tryptophan Metabolism Alterations, Celiac Disease | Not applicable | Recruiting | McMaster University | 50 | 2022-12-01 | 2025-01-10 |
| Anaesthesia and Tryptophan Pathway tryptophan - Tryptophan Pathway | Unknown | Assiut University | 48 | 2020-07-08 | 2020-07-16 | |
| The Effects of Kynurenine Aminotransferase Inhibition in People With Schizophrenia N-acetylcysteine (NAC), Placebo, Tryptophan - Schizophrenia, Schizoaffective Disorder | Phase 1 / Phase 2 | Completed | University of Maryland, Baltimore | 88 | 2020-01-20 | 2026-02-11 |
| Effect of the Quality of Dietary Proteins on the Sleep Young Elite Athletes and the Obese Adolescent tryptophan - Obese Adolescent, Elite Adolescent Athletes | Not applicable | Unknown | University Hospital, Clermont-Ferrand | 48 | 2019-11-04 | 2019-11-14 |
| Effects of Nutritional Strategies or Manual Therapies in Women With Fibromyalgia Mediterranean-diet enriched with a higher dose of tryptophan and magnesium, Isocaloric diet, Manual therapy - Fibromyalgia | Not applicable | Completed | University of Alicante | 24 | 2019-05-01 | 2020-05-12 |
| The Role of Dietary Tryptophan on Aryl Hydrocarbon Receptor Activation L-tryptophan, Placebo - Diet Modification | Not applicable | Completed | McMaster University | 20 | 2017-11-01 | 2023-04-13 |
| Tryptophan Depletion in PD Patients Treated With STN DBS Tryptophan (TRP) depletion, Placebo, Stimulator ON - Parkinson's Disease | Not applicable | Terminated | Maastricht University Medical Center | 7 | 2015-11-01 | 2018-08-22 |
| Pilot Study: Combining Nutritional Supplements With Standard Antidepressant to Treat Depression. L-tyrosine, L-Tryptophan, deplin - Depression | Not applicable | Withdrawn | John D. Dingell VA Medical Center | 2015-11-01 | 2020-02-21 | |
| Nutrients to Enhance Sleep Quality and Quantity Tryptophan - Sleepiness in Athletes | Not applicable | Completed | PepsiCo Global R&D | 62 | 2015-06-01 | 2018-09-14 |
| Metabolic Availability of Tryptophan From White Maize Tryptophan - Healthy | Not applicable | Completed | The Hospital for Sick Children | 7 | 2015-03-01 | 2016-11-15 |
| Mechanistic Approach to Preventing Atrophy and Restoring Function in Older Adults Essential Amino Acids (EAA), Placebo (Alanine) - Muscle Atrophy, Quality of Life | Phase 2 | Completed | University of Oregon | 80 | 2014-12-01 | 2024-07-23 |
| Tryptophan MRI in People With Schizophrenia and Healthy Controls Tryptophan, Placebo - Schizophrenia | Phase 2 / Phase 3 | Completed | University of Maryland, Baltimore | 93 | 2014-08-14 | 2024-07-30 |
| Effect of Amino Acids and Sugar Alcohols on Satiation Peptides and Activation of Specific Brain Regions 1.56 g L-Tryptophan, 1.56 g L-Leucine, 50 g Xylitol - Endocrine System Diseases | Not applicable | Completed | University Hospital, Basel, Switzerland | 20 | 2014-05-01 | 2017-02-28 |
| Effect of Amino Acids and Sugar Alcohols on Gastric Emptying and Release of Satiation Peptides in Humans 0.52 g L-Tryptophan, 1.56 g L-Tryptophan, 1.56 g L-Leucine - Endocrine System Diseases | Not applicable | Completed | University Hospital, Basel, Switzerland | 20 | 2014-05-01 | 2015-09-30 |
| Tryptophan Requirement of Healthy School Age Children tryptophan - Healthy | Not applicable | Completed | The Hospital for Sick Children | 7 | 2013-12-01 | 2018-02-09 |
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Endocrine System Diseases (2) · Schizophrenia (2) · Alzheimer Disease (1) · Celiac Disease (1) · Chronic Disease (1) · Cocaine-Related Disorders (1) · Depression (1) · Fibromyalgia (1) · Irritable Bowel Syndrome (1) · Muscular Atrophy (1) · Obesity (1) · Parkinson Disease (1) · Pouchitis (1) · Psychotic Disorders (1) · Social Behavior (1)
The Hospital for Sick Children (4) · Maastricht University Medical Center (2) · McMaster University (2) · University Hospital, Basel, Switzerland (2) · University of Maryland, Baltimore (2) · Assiut University (1) · Fundació Sant Joan de Déu (1) · Gitte Moos Knudsen (1) · John D. Dingell VA Medical Center (1) · KU Leuven (1) · National Institute on Drug Abuse (NIDA) (1) · PepsiCo Global R&D (1) · Queen's University (1) · University Hospital, Clermont-Ferrand (1) · University of Adelaide (1)
Canada (7) · United States (5) · Netherlands (2) · Switzerland (2) · Australia (1) · Belgium (1) · Denmark (1) · Egypt (1) · France (1) · Spain (1)
Christoph Beglinger, Prof. (2) · Robert W Buchanan, M.D. (2) · A AM Masclee, Prof. Dr. (1) · Donald F Weaver, MD, PhD (1) · Eric C Strain, M.D. (1) · F Troost, PhD (1) · Gitte M Knudsen, DMSc (1) · Glenda Courtney Martin, PhD, RD (1) · Glenda Courtney-Martin, PhD, RD (1) · Livia Fantini (1) · Paul B Pencharz, MD, PhD (1) · Paul Pencharz, MD, PhD, (1) · Premysl Bercik, MD, PhD (1)
PMID 22301931, PMID 23731747, PMID 24943480, PMID 26733251, PMID 26829246, PMID 27158904, PMID 27875537, PMID 29741697, PMID 30280129, PMID 30753549, PMID 31343947, PMID 37118058, PMID 42727854
2009 (1), 2025 (1), P50MH103222 (1), R01AG046401 (1)