12 completed, 2 not yet recruiting, 2 unknown, 1 recruiting. 11 Not applicable, 2 Phase 1, 2 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 11 | Completed 7, Unknown 2, Not yet recruiting 1, Recruiting 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 3 | 2 | Completed 2 |
| Phase 4 | 1 | Completed 1 |
Follow Toothpaste: new trials by email Literature Review of Toothpaste trials Research Report on Toothpaste
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Using Miswak in Addition to Oral Hygiene Products in Patients With Gingivitis Miswak, Toothpaste - Gingivitis; Chronic | Not yet recruiting | Mustafa Kemal University | 36 | 2026-07-04 | 2026-07-08 | |
| The Purpose of This Research Study is to Compare the Effectiveness of a Non-fluoride Sensitive Whitening Toothpaste, Containing 5% KNO3 (Test) to That of a Non-whitening Fluoride Toothpaste (Negative Control) in Improving Tooth Whiteness (Removal of Extrinsic Stains Over 4 Weeks of Unsupervised Use. Toothpaste - Teeth Staining | Not applicable | Completed | Boka LLC | 100 | 2026-05-11 | 2026-08-13 |
| The Purpose of This Research Study is to Compare the Effectiveness of a Non-fluoride Whitening Toothpaste (Test) to That of a Non-whitening Fluoride Toothpaste (Negative Control) in Improving Tooth Whiteness (Removal of Extrinsic Stains) Over 8 Weeks of Unsupervised Use. Toothpaste - Teeth Staining | Not applicable | Completed | Boka LLC | 109 | 2025-09-11 | 2026-08-11 |
| A Clinical Study to Evaluate the Stain Reduction Efficacy of a Non-Fluoride Tooth Whitening Dentifrice Containing Nano-Hydroxyapatite (nHAP) and a High Cleaning Silica Abrasive System Compared to a Commercial Fluoride Non-Whitening Dentifrice as a Negative Control toothpaste - Teeth Color, Teeth Staining | Not applicable | Completed | Boka LLC | 120 | 2025-09-01 | 2026-08-11 |
| A Pilot Study to Test the Efficacy of a Commercial Toothpaste (Cosmetic Product) Toothpaste - Periodontitis | Not applicable | Recruiting | Periotrap Pharmaceuticals GmbH | 28 | 2025-07-28 | 2026-09-01 |
| Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and Gingivitis Mouthwash, Floss, Toothbrush - Dental Plaque, Gingivitis | Phase 4 | Completed | Colgate Palmolive | 228 | 2025-07-07 | 2025-10-30 |
| Effectiveness of Calcium Silicate and Sodium Fluoride Nanoparticles in The Management of Dentin Hypersensitivity toothpaste - Dentin Hypersensitivity | Not applicable | Not yet recruiting | Minia University | 60 | 2025-05-01 | 2025-05-11 |
| Comparative Study of CPC+Zn Mouthwash, Dental Floss, and Essential Oils Mouthwash on Plaque and Gingivitis Reduction Mouthwash CPC+Zn+F, Essential oils mouthrinse, Dental floss - Gingival Bleeding, Plaque Induced Gingival Disease | Phase 3 | Completed | Colgate Palmolive | 120 | 2024-09-16 | 2025-04-14 |
| Evaluation of Toothpaste on Dental Plaque Toothpaste - Dental Plaque | Not applicable | Unknown | Marmara University | 50 | 2023-05-26 | 2023-05-22 |
| Measurement of Viral Load Reduction in the Oral Cavity After a Regimental Use of OC Toothpaste Products Colgate Total Clean Mint, Tom's Botanically Bright Peppermint - Covid19 | Phase 3 | Completed | Colgate Palmolive | 46 | 2020-12-28 | 2022-01-18 |
| Dentifrice With Innovative Remineralizing Technology DENTIFRICE - Initial Dental Caries | Not applicable | Unknown | Federal University of Paraíba | 20 | 2020-02-03 | 2023-02-08 |
| Oral Health Promotion Interventions Amongst Stroke Survivors During Rehabilitation Powered toothbrush, Manual toothbrush, Toothpaste - Stroke | Not applicable | Completed | The University of Hong Kong | 94 | 2013-04-01 | 2017-04-17 |
| Impact of Milk on Erosion/Abrasion of Enamel and Dentin - an in Situ Study Toothpaste, Milk, Fluoridated Milk - Erosion Protection | Not applicable | Completed | University of Zurich | 15 | 2012-01-01 | 2013-07-18 |
| Fluoride Availability in Saliva After Use of Sodium Fluoride or Monofluorophosphate Toothpastes Toothpaste - Dental Caries | Phase 1 | Completed | University of Campinas, Brazil | 12 | 2011-08-01 | 2012-05-02 |
| Anticaries Potential and Fluorosis Risk From Different Fluoride Toothpastes Toothpaste - Dental Caries, Dental Fluorosis | Phase 1 | Completed | University of Campinas, Brazil | 24 | 2011-01-01 | 2013-10-28 |
| Chlorhexidine Gluconate Oral Care for Adults Experiencing Trauma Chlorhexidine gluconate, Toothpaste - Ventilator Associated Pneumonia | Not applicable | Completed | St. Joseph's Hospital and Medical Center, Phoenix | 66 | 2010-07-01 | 2017-02-06 |
| Experimental Denture Pastes Dentifrice - Dental Plaque, Denture Stomatitis | Not applicable | Completed | Raphael Freitas de Souza | 36 | 2008-02-01 | 2014-07-28 |
Dental Plaque (4) · Gingivitis (3) · Tooth Discoloration (3) · Dental Caries (2) · Periodontal Diseases (2) · Bronchiolitis Obliterans Syndrome (1) · COVID-19 (1) · Candidiasis, Oral (1) · Dentin Sensitivity (1) · Fluorosis, Dental (1) · Gingival Hemorrhage (1) · Mouth, Edentulous (1) · Periodontitis (1) · Pneumonia, Ventilator-Associated (1) · Stomatitis, Denture (1)
Boka LLC (3) · Colgate Palmolive (3) · University of Campinas, Brazil (2) · Federal University of Paraíba (1) · Marmara University (1) · Minia University (1) · Mustafa Kemal University (1) · Periotrap Pharmaceuticals GmbH (1) · Raphael Freitas de Souza (1) · St. Joseph's Hospital and Medical Center, Phoenix (1) · The University of Hong Kong (1) · University of Zurich (1)
Brazil (5) · United States (5) · Germany (1) · India (1) · Switzerland (1) · Turkey (Türkiye) (1)
Livia MA Tenuta, PhD (2) · Annette Wiegand, PD Dr. med. dent. (1) · Cassiano K Rosing, PhD (1) · Colman McGrath, PhD (1) · Hasan Burak Sen, DDs (1) · Helena FO Paranhos, DDS, PhD (1) · Jeffery L Milleman, DDS, MPA (1) · Jeffery Milleman, DDS, MPA (1) · Thomas Attin, Prof. Dr. med. dent. (1) · Tracy Thomas, MSN (1)