Effect of Non-Surgical Periodontal Therapy on Serum Asprosin in Patients With Stable Angina
| Registry | NCT07591844 |
|---|---|
| Status | Not yet recruiting |
| Phase | Not applicable |
| Study type | Interventional; randomized, parallel, masking: none, treatment |
| Enrollment | 60 (Estimated) |
| Sponsor | Ondokuz Mayıs University (Other) |
| Conditions | Stable Angina Pectoris, Periodontitis |
| Interventions | Non-surgical periodontal therapy (scaling and root planing), Non-surgical periodontal therapy (Professional dental cleaning) (Procedure) |
| Dates | start 2026-05-20 (estimated), primary completion 2026-08-20 (estimated), completion 2026-10-20 (estimated), first posted 2026-05-18, last updated 2026-05-18 |
| Locations | 1 site in Turkey (Türkiye) |
Related Papers Related Patents Related Grants Related Experts
All trials for Stable Angina Pectoris All trials for Periodontitis All trials of Non-surgical periodontal therapy (scaling and root planing) All trials of Non-surgical periodontal therapy (Professional dental cleaning)
This study aims to evaluate the effect of non-surgical periodontal therapy on serum asprosin levels in patients with stable angina and periodontitis. Asprosin is a novel metabolic biomarker reported to have potential protective roles in cardiovascular diseases and inflammatory processes. The study also investigates the relationship between periodontal parameters and serum asprosin levels before and after periodontal therapy.
Periodontitis is a chronic inflammatory disease characterized by the destruction of the tooth-supporting tissues and has been associated with increased systemic inflammation and cardiovascular diseases. Stable angina, a clinical manifestation of coronary artery disease, is closely linked to inflammatory and metabolic pathways. Increasing evidence suggests that periodontal inflammation may contribute to cardiovascular pathology through systemic dissemination of inflammatory mediators and oxidative stress mechanisms.
Asprosin is a recently identified adipokine secreted mainly from white adipose tissue and is involved in glucose metabolism, inflammatory regulation, and cardiovascular homeostasis. Previous studies have reported altered serum asprosin levels in patients with atherosclerosis, myocardial infarction, and periodontitis. However, the effect of periodontal therapy on serum asprosin levels in patients with stable angina has not yet been clinically investigated.
In this clinical study, 60 individuals will be allocated into three groups: healthy controls, periodontitis patients, and patients with stable angina and periodontitis. Non-surgical periodontal therapy will be performed in periodontitis groups, while supragingival scaling and oral hygiene instructions will be provided for controls. Clinical periodontal parameters and serum asprosin levels will be evaluated at baseline and at 3-month follow-up using ELISA analysis.
The study aims to determine whether periodontal therapy may influence serum asprosin levels and to evaluate the possible relationship between periodontal inflammation and metabolic-inflammatory pathways in cardiovascular disease. To the best of our knowledge, this is the first clinical study evaluating the effect of periodontal therapy on serum asprosin levels in patients with stable angina.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| Stable angina and periodontitis group (SAP group) | Experimental | Procedure: Non-surgical periodontal therapy (scaling and root planing) | Individuals with angiographically confirmed stable angina and periodontitis who will receive non-surgical periodontal therapy, including scaling and root planing |
| Periodontitis group (P group) | Experimental | Procedure: Non-surgical periodontal therapy (scaling and root planing) | Individuals with angiographically confirmed cardiovascular health and periodontitis who will receive non-surgical periodontal therapy, including scaling and root planing |
| Control group (C group) | Active comparator | Procedure: Non-surgical periodontal therapy (Professional dental cleaning) | Periodontally healthy individuals with angiographically confirmed absence of coronary artery disease who will receive routine professional dental cleaning and standardized oral hygiene instruction |
Sex: All, ages: 18 Years to 65 Years, accepts healthy volunteers
Inclusion Criteria: * Willingness to participate in the study and provide written informed consent * Age 18 years or older * No periodontal treatment within the past 6 months * No use of local or systemic antibiotics within the past 3 months Exclusion Criteria: * Unwillingness to participate in the study or to provide informed consent * Age under 18 years * Use of local or systemic antibiotics for the treatment of widespread infection within the past 3 months * Receipt of periodontal treatment within the past 6 months * Pregnancy or lactation (for female participants) * History of acute myocardial infarction within the past 6 months
| Facility | City | Country | Status |
|---|---|---|---|
| Ondokuz Mayis University | Samsun, Atakum | Turkey (Türkiye) |