4 completed, 3 unknown, 2 recruiting, 1 active not recruiting. 4 Phase 2, 4 Phase 3, 2 Phase 4, 1 Not applicable, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Recruiting 2, Completed 1, Withdrawn 1 |
| Phase 3 | 4 | Unknown 2, Active not recruiting 1, Terminated 1 |
| Phase 4 | 2 | Completed 2 |
| Not applicable | 1 | Unknown 1 |
| Phase 1 | 1 | Completed 1 |
Follow tocopherol: new trials by email Literature Review of tocopherol trials Research Report on tocopherol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose) Pravastatin (drug), Pentoxifylline, ketoprofen - Fibrosis Syndrome, Lymphedema | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 250 | 2025-08-08 | 2026-07-24 |
| Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE) Pravastatin, Pentoxifylline, Tocopherol - Lymphedema, Fibrosis | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 295 | 2025-02-13 | 2026-09-11 |
| The Effect of Vitamin C and E Therapy on Restless Leg Syndrome in Patients With End Stage Renal Disease on Haemodialysis Ascorbic acid, Tocopherol, Placebo capsule - Restless Legs Syndrome, End Stage Renal Disease | Phase 3 | Unknown | King Abdulaziz University | 160 | 2022-11-01 | 2022-08-24 |
| Clinical Efficacy Analysis of Resveratrol in the Treatment of Primary Ovarian Insufficiency Resveratrol, Vitamin E - Primary Ovarian Insufficiency | Not applicable | Unknown | Affiliated Hospital of Nantong University | 150 | 2022-02-01 | 2022-06-08 |
| Role of Vitamin E in Reducing Dry Socket Vitamin E application - Dry Socket | Phase 4 | Completed | Ain Shams University | 40 | 2022-01-01 | 2023-08-09 |
| Lipid Peroxidation and Options Antioxidant Therapy for Secondary Lymphedema of the Lower Extremities Micronised purified flavonoid fraction (diosmin+flavonoids expressed as hesperidin), Tocopherol, Elastic compression - Lower Extremity Lymphedema | Phase 4 | Completed | Ryazan State Medical University | 120 | 2019-09-01 | 2022-08-04 |
| Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ) Pentoxifylline, Placebo, Tocopherol - Medication-related Osteonecrosis of the Jaw, Bisphosphonate-related Osteonecrosis of the Jaw | Phase 3 | Active not recruiting | University of Washington | 100 | 2018-04-01 | 2026-04-29 |
| Effect of House Dust Mite Allergen Challenge in Persons Using 1200 mg Gamma Tocopherol Supplements Gamma Tocopherol - Allergic Rhinitis, Mild Asthma | Phase 1 | Completed | University of North Carolina, Chapel Hill | 8 | 2007-03-01 | 2014-01-09 |
| Tocopherol is a Novel Treatment for Cancer Related Mucositis Tocopherol - Oral Mucositis | Phase 2 | Withdrawn | Hadassah Medical Organization | 30 | 2005-12-01 | 2011-04-08 |
| Vitamin E in Aging Persons With Down Syndrome Vitamin E, multivitamin, Placebo - Down Syndrome, Alzheimer Disease | Phase 3 | Unknown | New York State Institute for Basic Research | 350 | 2002-04-01 | 2012-05-04 |
| Efficacy and Safety of Pentoxyphilline and Tocopherol on the Fibrosis in Patients With Chronic Hepatitis C pentoxyphilline, tocopherol - Hepatitis C, Chronic, Liver Fibrosis | Phase 3 | Terminated | French National Agency for Research on AIDS and Viral Hepatitis | 100 | 2002-02-01 | 2007-01-12 |
| 13-Cis Retinoic Acid With or Without Vitamin E for Prevention of Lung Cancer 13-cis retinoic acid, Tocopherol - Drug Toxicity, Lung Cancer | Phase 2 | Completed | University of Colorado, Denver | 96 | 1993-01-01 | 2020-05-15 |
Fibrosis (2) · Lymphedema (2) · Alzheimer Disease (1) · Bisphosphonate-Associated Osteonecrosis of the Jaw (1) · Carcinoma, Non-Small-Cell Lung (1) · Down Syndrome (1) · Drug-Related Side Effects and Adverse Reactions (1) · Dry Socket (1) · Dust Mite Allergy (1) · Head and Neck Neoplasms (1) · Hepatitis C (1) · Hepatitis C, Chronic (1) · Kidney Failure, Chronic (1) · Liver Cirrhosis (1) · Lung Neoplasms (1)
M.D. Anderson Cancer Center (2) · Affiliated Hospital of Nantong University (1) · Ain Shams University (1) · French National Agency for Research on AIDS and Viral Hepatitis (1) · Hadassah Medical Organization (1) · King Abdulaziz University (1) · New York State Institute for Basic Research (1) · Ryazan State Medical University (1) · University of Colorado, Denver (1) · University of North Carolina, Chapel Hill (1) · University of Washington (1)
United States (6) · Australia (1) · Canada (1) · China (1) · Egypt (1) · France (1) · Israel (1) · Russia (1) · United Kingdom (1)
Arthur J Dalton, PhD (1) · Clifton Fuller, MD (1) · Clifton Fuller, MD,PHD (1) · David B Peden, MS/MD (1) · Helene Fontaine, MD (1) · Jasjit Dillon, DDS, MBBS (1) · Mary C Sano, PhD (1) · Michellle Hernandez, MD (1) · Paul S Aisen, MD (1) · Shimon Slavin, MD (1) · York E. Miller, MD (1)
PMID 12190139, PMID 19401528, PMID 35866376
R01AG016381 (1)