29 completed, 7 unknown, 4 terminated, 1 withdrawn. 41 Phase 2, 9 Phase 3, 4 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 41 | Completed 29, Unknown 7, Terminated 4, Withdrawn 1 |
| Phase 3 | 9 | Completed 5, Unknown 3, Terminated 1 |
| Phase 1 | 4 | Completed 3, Unknown 1 |
Follow Ticagrelor: new trials by email Literature Review of Ticagrelor trials Research Report on Ticagrelor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| De-escalation of Ticagrelor in Post PPCI Ticagrelor 60mg - Ticagrelor | Phase 1 / Phase 2 | Unknown | Assiut University | 400 | 2023-06-01 | 2023-04-26 |
| A Study to Evaluate BMS-986141 Added on to Aspirin or Ticagrelor or the Combination, on Thrombus Formation in a Thrombosis Chamber Model in Participants With Stable Coronary Artery Disease and Healthy Participants Ticagrelor, BMS-986141, Aspirin - Coronary Artery Disease, Healthy Participants | Phase 2 | Completed | Bristol-Myers Squibb | 58 | 2022-03-25 | 2023-12-05 |
| Ticagrelor Monotherapy After Stenting Ticagrelor 90mg - Acute Myocardial Infarction | Phase 2 | Completed | Vastra Gotaland Region | 200 | 2021-12-14 | 2026-03-20 |
| Optical Coherence Tomography-Guided PCI With Single-Antiplatelet Therapy Prasugrel 10mg, Ticagrelor 90mg - Non ST Segment Elevation Acute Coronary Syndrome | Phase 2 | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 75 | 2021-02-19 | 2023-03-06 |
| The Effects of loW Dose tIcagrelor on Platelet Function Testing in Patients With Stable Coronary arTery Disease Ticagrelor - Platelet Dysfunction Due to Drugs | Phase 1 / Phase 2 | Completed | The University of The West Indies | 25 | 2019-10-01 | 2020-05-21 |
| SYNergy Stent® System Implantation With Mandatory Intra-VascularUltra-Sound Guidance and Dual Anti-Platelet Therapy Dual Antiplatelet (DAPT) Therapy, The Synergy® stent - Coronary Artery Disease, Atherosclerosis | Phase 2 | Terminated | HonorHealth Research Institute | 50 | 2018-11-19 | 2024-12-27 |
| Efficacy and Safety of Low-dose Ticagrelor Ticagrelor, ticagrelor, clopidogrel - Coronary Artery Disease | Phase 2 / Phase 3 | Completed | First Affiliated Hospital of Harbin Medical University | 3043 | 2017-12-13 | 2019-09-30 |
| Platelet Aggregation in Patients With Coronary Artery Disease and Kidney Dysfunction Taking Clopidogrel or Ticagrelor Clopidogrel, Ticagrelor - Platelet Aggregation, Adenosine | Phase 2 | Completed | University of Sao Paulo | 90 | 2017-11-07 | 2020-04-24 |
| Half-dose Ticagrelor Overcomes High-dose Clopidogrel in Acute Coronary Syndrome Patients With High On-Clopidogrel Platelet Reactivity Clopidogrel, ticagrelor - Coronary Artery Disease, Clopidogrel, Poor Metabolism of | Phase 2 / Phase 3 | Unknown | First Affiliated Hospital of Harbin Medical University | 80 | 2017-02-10 | 2018-05-07 |
| TIMES: Ticagrelor vs. Placebo/ Clopidogrel With Aspirin in Anterior STEMI Patients Treated With Primary PCI Ticagrelor, Placebo - ST Elevation Myocardial Infarction | Phase 2 | Unknown | Papworth Hospital NHS Foundation Trust | 140 | 2017-01-30 | 2017-05-30 |
| Ticagrelor Versus Clopidogrel in Carotid Artery Stenting Ticagrelor, Clopidogrel, Aspirin - Carotid Artery Stenosis | Phase 2 | Completed | University Hospital, Basel, Switzerland | 210 | 2016-12-01 | 2022-06-28 |
| Crushed Ticagrelor Versus Eptifibatide Bolus + Clopidogrel Ticagrelor, Eptifibatide, Clopidogrel - Acute Coronary Syndrome, Angina, Unstable | Phase 2 | Completed | University of Alabama at Birmingham | 100 | 2016-11-01 | 2020-05-04 |
| Effects of Different Doses of Ticagrelor on Platelet Aggregation and Endothelial Function in Diabetic Patients With Stable Coronary Artery Disease ticagrelor, clopidogrel - Coronary Artery Disease | Phase 2 / Phase 3 | Unknown | First Affiliated Hospital of Harbin Medical University | 60 | 2016-08-01 | 2017-02-23 |
| Ticagrelor vs. Prasugrel Effects on Infarct Size ticagrelor, prasugrel, Placebo - Cardiovascular Disease | Phase 2 | Withdrawn | Yochai Birnbaum | 2016-02-01 | 2016-05-04 | |
| ComparisoN of ticAgrelor vs. Clopidogrel in endoTHeliAl Function of COPD patieNts Aspirin 100 mg, Ticagrelor, Clopidogrel - Coronary Artery Disease, Chronic Obstructive Pulmonary Disease | Phase 2 | Completed | University Hospital of Ferrara | 44 | 2015-09-01 | 2018-05-02 |
| Anti-platelet Therapy in the Prevention of Cardiovascular Disease in Patients With COPD (APPLE-COPD: ICON 2) Ticagrelor, Aspirin, Placebo Aspirin - Chronic Obstructive Pulmonary Disease (COPD) | Phase 2 | Completed | Newcastle-upon-Tyne Hospitals NHS Trust | 120 | 2015-09-01 | 2018-04-04 |
| Platelet Reactivity in Acute Non-disabling Cerebrovascular Events Ticagrelor and Acetylsalicylic acid, Clopidogrel and Acetylsalicylic acid - Stroke, Ischemic Attack, Transient | Phase 2 / Phase 3 | Completed | Beijing Tiantan Hospital | 675 | 2015-08-01 | 2020-07-24 |
| A Study to Assess the Effect of Ticagrelor in Reducing the Number of Days With Pain in Patients With Sickle Cell Disease Ticagrelor, Placebo - Sickle Cell Disease | Phase 2 | Completed | AstraZeneca | 87 | 2015-07-09 | 2018-12-19 |
| Comparison of Low-Dose, Standard-Dose Ticagrelor and Clopidogrel for Inhibition of Platelet Reactivity in Patients With Acute Coronary Syndromes ticagrelor, clopidogrel - Acute Coronary Syndrome | Phase 2 | Completed | Seung-Jung Park | 65 | 2015-05-20 | 2017-06-16 |
| A Study to Compare the Safety of Rivaroxaban Versus Acetylsalicylic Acid in Addition to Either Clopidogrel or Ticagrelor Therapy in Participants With Acute Coronary Syndrome Acetylsalicylic acid, Rivaroxaban, Clopidogrel - Acute Coronary Syndrome | Phase 2 | Completed | Janssen Research & Development, LLC | 3037 | 2015-04-20 | 2017-12-26 |
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Coronary Artery Disease (14) · Acute Coronary Syndrome (6) · Myocardial Infarction (4) · Cardiovascular Diseases (3) · ST Elevation Myocardial Infarction (3) · Angina, Stable (2) · Angina, Unstable (2) · Peripheral Arterial Disease (2) · Peripheral Vascular Diseases (2) · Pulmonary Disease, Chronic Obstructive (2) · Anemia, Sickle Cell (1) · Aneurysm (1) · Aortic Aneurysm, Abdominal (1) · Arterial Occlusive Diseases (1) · Arteriosclerosis (1)
AstraZeneca (5) · First Affiliated Hospital of Harbin Medical University (3) · Medical University of Vienna (2) · Ottawa Heart Institute Research Corporation (2) · University of Alabama at Birmingham (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Assiut University (1) · Beijing Tiantan Hospital (1) · Bristol-Myers Squibb (1) · Chinese PLA General Hospital (1) · Gordon Bernard (1) · Hellenic Cardiovascular Research Society (1) · HonorHealth Research Institute (1) · Hyeon-Cheol Gwon (1) · Janssen Research & Development, LLC (1)
United States (17) · United Kingdom (8) · Canada (4) · China (4) · Italy (3) · Netherlands (3) · South Korea (3) · Sweden (3) · Austria (2) · Belgium (2) · Brazil (2) · Denmark (2) · France (2) · Japan (2) · Switzerland (2)
Massoud Leesar, MD (2) · Anders Wanhainen, MD. PhD (1) · Bernd Jilma, Ao. Univ.-Prof. Dr. med (1) · Charalambos Vlachopoulos (1) · David E. Newby, PhD (1) · David J. Schneider, MD (1) · David Rizik, MD (1) · Dominick Angiolillo, MD, PhD (1) · Gordon R Bernard, MD (1) · Hyeon-Cheol Gwon, MD/PhD (1) · Jay Horrow, MD (1) · Jon D Truwit, MD (1)
PMID 21079055, PMID 22212857, PMID 22795280, PMID 19923168, PMID 20194878, PMID 20620737, PMID 26404199, PMID 26995378, PMID 28325638, PMID 28331925, PMID 28373244, PMID 28381198, PMID 28427585, PMID 28465300, PMID 28611098, PMID 29622168, PMID 29629845, PMID 31081522, PMID 31135888, PMID 31141104, PMID 31165663, PMID 31171523, PMID 31382765, PMID 31422134, PMID 31535314, PMID 31766977, PMID 32052517, PMID 32587571, PMID 32766961, PMID 33297761, PMID 34187187, PMID 35224730, PMID 38357820
2014 (2)