9 completed, 2 recruiting, 1 not yet recruiting. 7 Not applicable, 4 Phase 2, 1 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Completed 5, Not yet recruiting 1, Recruiting 1 |
| Phase 2 | 4 | Completed 4 |
| Phase 1 | 1 | Completed 1 |
| Phase 4 | 1 | Recruiting 1 |
Follow threonic acid: new trials by email Literature Review of threonic acid trials Research Report on threonic acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| UCLA Magnesium Formulation Athlete Study Magnesium glycinate, Magnesium L-threonate, Placebo - Athletic Performance, Recovery | Not applicable | Recruiting | University of California, Los Angeles | 150 | 2026-10-05 | 2026-10-15 |
| Sex-Divergent Effects of Magnesium L-Threonate Supplementation on Sleep Quality, Cognitive Performance, and Neuromuscular Function in Healthy Adults Magnesium L-threonate, Placebo - Healthy Adults; Cognitive Performance; Sleep Quality; Neuromuscular Function | Not applicable | Completed | Barry University | 81 | 2025-12-01 | 2026-07-15 |
| Effects of Magnesium L-Threonate on Sleep, Recovery, and Athletic Performance in Collegiate Athletes Magnesium L-Threonate, Placebo - Recovery of Function (G11.427.698.620), Athletic Performance | Not applicable | Completed | University of California, Los Angeles | 109 | 2025-10-01 | 2026-10-20 |
| Magnesium-L-Threonate Improves Menopausal Symptoms Magnesium-L-Threonate, Placebo - Menopause Syndrome, Magnesium | Not applicable | Not yet recruiting | Guangdong Provincial People's Hospital | 50 | 2025-05-15 | 2025-05-07 |
| Magnesium-L-Threonate for Sleep Quality Post-Arthroplasty Magnesium Threonate, Control - Sleep, Knee Osteoarthritis | Phase 4 | Recruiting | University of Miami | 64 | 2025-04-21 | 2026-07-09 |
| Supplement Combination on Stress and Sleep All Active Supplement Combinations (Ashwagandha, Rhodiola rosea, magnesium threonate, L-theanine, and apigenin)), AM Active Supplement Combination (Ashwagandha and Rhodiola rosea), PM Active Supplement Combination (Magnesium threonate, L-theanine, and apigenin) - Healthy | Not applicable | Completed | University of South Carolina | 115 | 2025-02-15 | 2026-02-11 |
| Comparison of MMFS Dosages in Older Adults Low Dose MMFS-205-SR, High Dose MMFS-205-SR, Placebo - Anxiety, Depression | Phase 2 | Completed | Neurocentria, Inc. | 9 | 2018-07-23 | 2020-09-09 |
| Efficacy and Safety of MMFS in Early AD MMFS-205-SR, Placebo - Alzheimer Disease | Phase 2 | Completed | Neurocentria, Inc. | 10 | 2018-03-20 | 2020-09-09 |
| Magnesium Supplementation in People With XMEN Syndrome Magnesium L-threonate, Placebo, Intravenous (IV) magnesium sulfate (MgSO4) - XMEN | Phase 1 / Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 8 | 2016-05-17 | 2022-03-02 |
| L-Threonic Acid Magnesium Salt (L-TAMS) in ADHD L-Threonic Acid Magnesium Salt (L-TAMS) - Attention Deficit/Hyperactivity Disorder, ADHD | Phase 2 | Completed | Massachusetts General Hospital | 20 | 2016-03-01 | 2018-05-14 |
| Magnesium L-Threonate for the Enhancement of Learning and Memory in People With Dementia Magtein - Dementia, Alzheimer's Disease | Not applicable | Completed | Stanford University | 17 | 2014-07-01 | 2021-02-02 |
| Clinical Trial to Evaluate Magtein in Older Adults magnesium threonate - Mood, Anxiety | Not applicable | Completed | Miami Research Associates | 50 | 2012-08-01 | 2015-02-16 |
Sleep Initiation and Maintenance Disorders (4) · Alzheimer Disease (2) · Anxiety Disorders (2) · Attention Deficit Disorder with Hyperactivity (1) · Cognitive Dysfunction (1) · Dementia (1) · Depression (1) · Epstein-Barr Virus Infections (1) · Infections (1) · Mental Fatigue (1) · Neoplasms (1) · Osteoarthritis, Knee (1) · Primary Immunodeficiency Diseases (1)
Neurocentria, Inc. (2) · University of California, Los Angeles (2) · Barry University (1) · Guangdong Provincial People's Hospital (1) · Massachusetts General Hospital (1) · Miami Research Associates (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Stanford University (1) · University of Miami (1) · University of South Carolina (1)
United States (11) · China (1)
Craig Surman, MD (1) · Donald Burkindine, MD (1) · Douglas W Scharre, MD (1) · Jeremy Swisher, MD (1) · Joshua Goldman, MD (1) · Juan C Ravell Aumaitre, M.D. (1) · Natalie L Rasgon, MD, Ph.D (1) · Victor H Hernandez, MD (1)