6 completed, 4 unknown, 1 suspended. 4 Not applicable, 4 Phase 4, 1 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Completed 3, Unknown 1 |
| Phase 4 | 4 | Unknown 2, Completed 1, Suspended 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 3 | 1 | Unknown 1 |
Follow Thiazides: new trials by email Literature Review of Thiazides trials Research Report on Thiazides
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload Acetazolamide, Metolazone, IV Loop Diuretics - Acute Decompensated Heart Failure, Volume Overload | Phase 4 | Unknown | Cairo University | 110 | 2024-07-01 | 2024-07-24 |
| Early Sequential Nephron Blockade in Acute Heart Failure Patients: A Randomised, Controlled Study Spironolactone or hydrochlorothiazide, Placebo - Acute Heart Failure, Acute Kidney Injury | Phase 3 | Unknown | Chiang Mai University | 100 | 2020-08-13 | 2020-08-18 |
| Coronavirus (COVID-19) ACEi/ARB Investigation Thiazide or Thiazide-like diuretics, Calcium Channel Blockers, ACE inhibitor - Hypertension, COVID-19 | Phase 4 | Suspended | National University of Ireland, Galway, Ireland | 2414 | 2020-04-30 | 2020-06-30 |
| Impact of Integrated HIV/NCD Screening on HIV Testing Uptake and Engagement in HIV Care in Kisarawe, Tanzania Blood glucose and blood pressure testing, Diet and lifestyle counseling, DM/HTN medications as needed - Human Immunodeficiency Virus, Diabetes Mellitus, Type 2 | Not applicable | Completed | Medical University of South Carolina | 214 | 2018-02-05 | 2024-10-30 |
| Replication of the TRANSCEND Antihypertensive Trial in Healthcare Claims Data Loop diuretics, thiazides, dihydropyridines, Telmisartan - Hypertension | Completed | Brigham and Women's Hospital | 40048 | 2017-09-22 | 2023-07-27 | |
| Recombinant Human rhPTH(1-34) VS Association Alfacalcidol/Hydrochlorothiazide in Severe Primary Hypoparathyroidism Teriparatide, Thiazide, Potassium sparing diuretic - Autosomal Dominant Hypocalcemia OR Primary Hypoparathyroidism Related to Other Cause But Complicated by Hypercalciuria Under Treatment | Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 16 | 2017-06-06 | 2021-06-28 |
| Effect of RAS Blockers on CKD Progression in Elderly Patients With Non Proteinuric Nephropathies (PROERCAN01) Lisinopril, Amlodipine - Renal Insufficiency, Chronic, Proteinuria | Phase 4 | Unknown | Hospital General Universitario Gregorio Marañon | 106 | 2015-06-01 | 2019-02-22 |
| Hypertensive Ambulatory Trial to Compare the Efficacy of HCTZ and Lisinopril Lisinopril, Hydrochlorothiazide - Hypertension, Grade 1, Hypertension Treatment | Not applicable | Completed | Scripps Translational Science Institute | 2 | 2010-11-01 | 2015-05-20 |
| The Indian POLYCAP Study (TIPS) Thiazides, Ramipril with Thiazide, Thiazide plus atenolol - Cardiovascular Diseases | Not applicable | Completed | St. John's Research Institute | 2050 | 2007-03-01 | 2010-09-23 |
| Pharmacosurveillance and Pharmacogenetics of First-line Diuretics in Hypertension: The StayOnDiur Study thiazides, Non thiazidic treatment - Essential Hypertension | Phase 4 | Completed | Federico II University | 2500 | 2006-12-01 | 2011-06-27 |
| Early Metabolic Changes With Thiazide or Beta Blocker Therapy for Essential Hypertension Thiazide and beta blocker - Essential Hypertension | Not applicable | Unknown | University of Cambridge | 66 | 2006-09-01 | 2006-09-25 |
Hypertension (4) · Cardiovascular Diseases (2) · Essential Hypertension (2) · Acquired Immunodeficiency Syndrome (1) · Acute Kidney Injury (1) · COVID-19 (1) · Chronic Disease (1) · Coronavirus Infections (1) · Diabetes Mellitus, Type 2 (1) · Edema (1) · Hypercalciuria (1) · Hypoparathyroidism (1) · Lymphoma, Follicular (1) · Proteinuria (1) · Renal Insufficiency, Chronic (1)
Assistance Publique - Hôpitaux de Paris (1) · Brigham and Women's Hospital (1) · Cairo University (1) · Chiang Mai University (1) · Federico II University (1) · Hospital General Universitario Gregorio Marañon (1) · Medical University of South Carolina (1) · National University of Ireland, Galway, Ireland (1) · Scripps Translational Science Institute (1) · St. John's Research Institute (1) · University of Cambridge (1)
United States (2) · Egypt (1) · France (1) · India (1) · Ireland (1) · Italy (1) · Spain (1) · Tanzania (1) · Thailand (1) · United Kingdom (1)
Agnes Linglart, MD, PhD (1) · Anne Blanchard, MD, PhD (1) · Bradley Patay, MD (1) · Bruno Trimarco, MD (1) · Denis Xavier, MD Pharmac (1) · John William McEvoy, MBBCh MHS (1) · Kajohnsak Noppakun, MD (1) · Maria Angeles Goicoechea, PhD, MD (1) · Michael D. Sweat, PhD (1) · Prem Pais, MD Medicinie (1) · Professor MJ Brown, MA MSC MD FRCP (1) · Salim Yusuf, DPhil,FRCPC,FRSC (1) · Shirley Wang, PhD, ScM (1)
PMID 19104516, PMID 22493073, PMID 24956971, PMID 25695618, PMID 38508877
2016 (1), R01MH111366 (1)